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Article: Serum IgE concentration and other immune manifestations of treatment with gold salts are linked to the MHC and IL4 regions in the rat

TitleSerum IgE concentration and other immune manifestations of treatment with gold salts are linked to the MHC and IL4 regions in the rat
Authors
Issue Date1996
Citation
Genomics, 1996, v. 31 n. 1, p. 111-114 How to Cite?
AbstractA subset of patients with rheumatoid arthritis occasionally develops skin reactions and glomerulonephritis and exhibits an increase in serum IgE concentration when treated with gold salts. Brown-Norway (BN) rats injected with aurothiopropanolsulfonate (ATPS) also manifest an autoimmune glomerulonephritis and increased serum IgE concentration, whereas Lewis (LEW) rats are resistant to complications. Here, we show linkage between responses to ATPS in a (BN x LEW) F2 cohort and the major histocompatibility complex (RT1) on rat chromosome 20 and between markers in the region of IL4 and other candidate genes on rat chromosome 10. Recently, human serum IgE concentration has been reported to be linked to the IL-4 region. Taken together, these findings raise the possibility that homologous genes could be implicated in ATPS manifestations in the rat and in the regulation of IgE levels in the human.
Persistent Identifierhttp://hdl.handle.net/10722/195345
ISSN
2015 Impact Factor: 2.386
2015 SCImago Journal Rankings: 1.281
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorKermarrec, N-
dc.contributor.authorDubay, C-
dc.contributor.authorDe Gouyon, B-
dc.contributor.authorBlanpied, C-
dc.contributor.authorGauguier, D-
dc.contributor.authorGillespie, K-
dc.contributor.authorMathieson, PW-
dc.contributor.authorDruet, P-
dc.contributor.authorLathrop, M-
dc.contributor.authorHirsch, F-
dc.date.accessioned2014-02-28T06:12:01Z-
dc.date.available2014-02-28T06:12:01Z-
dc.date.issued1996-
dc.identifier.citationGenomics, 1996, v. 31 n. 1, p. 111-114-
dc.identifier.issn0888-7543-
dc.identifier.urihttp://hdl.handle.net/10722/195345-
dc.description.abstractA subset of patients with rheumatoid arthritis occasionally develops skin reactions and glomerulonephritis and exhibits an increase in serum IgE concentration when treated with gold salts. Brown-Norway (BN) rats injected with aurothiopropanolsulfonate (ATPS) also manifest an autoimmune glomerulonephritis and increased serum IgE concentration, whereas Lewis (LEW) rats are resistant to complications. Here, we show linkage between responses to ATPS in a (BN x LEW) F2 cohort and the major histocompatibility complex (RT1) on rat chromosome 20 and between markers in the region of IL4 and other candidate genes on rat chromosome 10. Recently, human serum IgE concentration has been reported to be linked to the IL-4 region. Taken together, these findings raise the possibility that homologous genes could be implicated in ATPS manifestations in the rat and in the regulation of IgE levels in the human.-
dc.languageeng-
dc.relation.ispartofGenomics-
dc.titleSerum IgE concentration and other immune manifestations of treatment with gold salts are linked to the MHC and IL4 regions in the rat-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1006/geno.1996.0016-
dc.identifier.pmid8808287-
dc.identifier.scopuseid_2-s2.0-0030038879-
dc.identifier.volume31-
dc.identifier.issue1-
dc.identifier.spage111-
dc.identifier.epage114-
dc.identifier.isiWOS:A1996TR63700016-

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