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  Patent History
  • Application
    PC T/US2006006661 2006-02-23
  • Publication
    WO 2006091852 2006-08-31
  Patent Family

Patent: NOVEL GENETIC APPROACHES TO REDUCE OR INHIBIT TUMORGENICITY OF HUMAN EMBRYONIC STEM CELLS AND DERIVATIVES FOLLOWING TRANSPLANTATION

TitleNOVEL GENETIC APPROACHES TO REDUCE OR INHIBIT TUMORGENICITY OF HUMAN EMBRYONIC STEM CELLS AND DERIVATIVES FOLLOWING TRANSPLANTATION
Priority Date2005-02-23 US 11/655322P
Inventors
Issue Date2006
Citation
WO Published patent application WO 2006091852. World Intellectual Property Organization (WIPO), PatentScope, 2006 How to Cite?
AbstractSelf-renewable embryonic stem cells (ESCs), derived from the inner cell mass of blastocysts, can propagate indefinitely in culture while maintaining their normal karyotypes and pluripotency to differentiate into all cell types. Therefore, ESCs may provide an unlimited supply of even specialized cells such as brain and heart cells for transplantation and cell-based therapies that are otherwise limited by donor availability. However, this promising application is hampered by concerns that ESCs or their multipotent derivatives also possess the potential to form malignant tumors after transplantation in vivo. The present invention provides for a novel genetic method to arrest undesirable cell division (of ESCs and other unwanted lineages) as a means to inhibit or eliminate their tumorgenic potential after transplantation.
Persistent Identifierhttp://hdl.handle.net/10722/195311

 

DC FieldValueLanguage
dc.date.accessioned2014-02-28T01:05:08Z-
dc.date.available2014-02-28T01:05:08Z-
dc.date.issued2006-
dc.identifier.citationWO Published patent application WO 2006091852. World Intellectual Property Organization (WIPO), PatentScope, 2006en_US
dc.identifier.urihttp://hdl.handle.net/10722/195311-
dc.description.abstractSelf-renewable embryonic stem cells (ESCs), derived from the inner cell mass of blastocysts, can propagate indefinitely in culture while maintaining their normal karyotypes and pluripotency to differentiate into all cell types. Therefore, ESCs may provide an unlimited supply of even specialized cells such as brain and heart cells for transplantation and cell-based therapies that are otherwise limited by donor availability. However, this promising application is hampered by concerns that ESCs or their multipotent derivatives also possess the potential to form malignant tumors after transplantation in vivo. The present invention provides for a novel genetic method to arrest undesirable cell division (of ESCs and other unwanted lineages) as a means to inhibit or eliminate their tumorgenic potential after transplantation.en_US
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License for public patent documentsen_US
dc.titleNOVEL GENETIC APPROACHES TO REDUCE OR INHIBIT TUMORGENICITY OF HUMAN EMBRYONIC STEM CELLS AND DERIVATIVES FOLLOWING TRANSPLANTATIONen_US
dc.typePatent-
dc.description.naturepublished_or_final_version-
dc.contributor.inventorLI, RONALD Aen_US
dc.contributor.inventorXUE, TIANen_US
dc.contributor.inventorLAU, CHU-PAKen_US
dc.contributor.inventorTSE, HUNG-FATen_US
patents.identifier.applicationPC T/US2006006661en_US
patents.description.assigneeUNIV JOHNS HOPKINS [US]; LI RONALD A [US]; XUE TIAN [US]; LAU CHU-PAK [US]; TSE HUNG-FAT [US]en_US
patents.description.countryWorld Intellectual Property Organization (WIPO)en_US
patents.date.publication2006-08-31en_US
patents.date.application2006-02-23en_US
patents.date.priority2005-02-23 US 11/655322Pen_US
patents.description.ccwoen_US
patents.identifier.publicationWO 2006091852en_US
patents.relation.familyUS 2011008888 (A1) 2011-01-13en_US
patents.description.kindA2en_US

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