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Article: Targets of c-Jun NH2-terminal kinase 2-mediated tumor growth regulation revealed by serial analysis of gene expression

TitleTargets of c-Jun NH2-terminal kinase 2-mediated tumor growth regulation revealed by serial analysis of gene expression
Authors
Issue Date2002
Citation
Cancer Research, 2002, v. 62 n. 11, p. 3257-3263 How to Cite?
AbstractAlthough the c-Jun NH2-terminal kinase (JNK) pathway has been implicated in mediating cell growth and transformation, its downstream effectors remain to be identified. Using JNK2 antisense oligonucleotides (JNK2AS), we uncovered previously a role for JNK2 in regulating cell cycle progression and survival of human PC3 prostate carcinoma cells. Here, to identify genes involved in implementing JNK2-mediated effects, we have analyzed global gene expression changes in JNK2-deprived PC3 cells using Serial Analysis of Gene Expression. More than 40,000 tags each were generated from control and PC3-JNK2AS libraries, corresponding to 15,999 and 20,698 unique transcripts, respectively. Transcripts corresponding to transcription factors, stress-induced genes, and apoptosis-related genes were up-regulated in the PC3-JNK2AS library, revealing a significant stress response after the inhibition of JNK2 expression. Genes involved in DNA repair, mRNA turnover, and drug resistance were found to be down-regulated by inhibition of JNK2 expression, further highlighting the importance of JNK2 signaling in regulating cell homeostasis and tumor cell growth.
Persistent Identifierhttp://hdl.handle.net/10722/195256
ISSN
2015 Impact Factor: 8.556
2015 SCImago Journal Rankings: 5.372
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorPotapova, O-
dc.contributor.authorAnisimov, SV-
dc.contributor.authorGorospe, M-
dc.contributor.authorDougherty, RH-
dc.contributor.authorGaarde, WA-
dc.contributor.authorBoheler, KR-
dc.contributor.authorHolbrook, NJ-
dc.date.accessioned2014-02-25T01:40:22Z-
dc.date.available2014-02-25T01:40:22Z-
dc.date.issued2002-
dc.identifier.citationCancer Research, 2002, v. 62 n. 11, p. 3257-3263-
dc.identifier.issn0008-5472-
dc.identifier.urihttp://hdl.handle.net/10722/195256-
dc.description.abstractAlthough the c-Jun NH2-terminal kinase (JNK) pathway has been implicated in mediating cell growth and transformation, its downstream effectors remain to be identified. Using JNK2 antisense oligonucleotides (JNK2AS), we uncovered previously a role for JNK2 in regulating cell cycle progression and survival of human PC3 prostate carcinoma cells. Here, to identify genes involved in implementing JNK2-mediated effects, we have analyzed global gene expression changes in JNK2-deprived PC3 cells using Serial Analysis of Gene Expression. More than 40,000 tags each were generated from control and PC3-JNK2AS libraries, corresponding to 15,999 and 20,698 unique transcripts, respectively. Transcripts corresponding to transcription factors, stress-induced genes, and apoptosis-related genes were up-regulated in the PC3-JNK2AS library, revealing a significant stress response after the inhibition of JNK2 expression. Genes involved in DNA repair, mRNA turnover, and drug resistance were found to be down-regulated by inhibition of JNK2 expression, further highlighting the importance of JNK2 signaling in regulating cell homeostasis and tumor cell growth.-
dc.languageeng-
dc.relation.ispartofCancer Research-
dc.titleTargets of c-Jun NH2-terminal kinase 2-mediated tumor growth regulation revealed by serial analysis of gene expression-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid12036942-
dc.identifier.scopuseid_2-s2.0-0036606371-
dc.identifier.volume62-
dc.identifier.issue11-
dc.identifier.spage3257-
dc.identifier.epage3263-
dc.identifier.isiWOS:000176038500041-

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