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Article: Characterization of a novel transcript of retroviral origin expressed in rat heart and liver

TitleCharacterization of a novel transcript of retroviral origin expressed in rat heart and liver
Authors
Issue Date1995
Citation
Journal of Molecular and Cellular Cardiology, 1995, v. 27 n. 1, p. 589-597 How to Cite?
AbstractEleven cDNA clones of retroviral origin (SORO) have been isolated and characterized from a rat cardiac cDNA library that are highly homologous to the RAL-element family of rat retroviral endogenous sequences. SORO-1, the largest of the clones isolated at approximately 3.5 kb, contains a characteristic long terminal repeat (LTR) that is unique to previously identified retroposons. Its LTR contains elements homologous to the CAAT box, a TATA box, a core enhancer sequence, and potential binding sites for GATA. SORO-1 hybridizes to a mRNA of approximately 7 kb, that is present both in rat heart and liver. This transcript was not, however, detected in other tissues (fast and slow skeletal muscles, brain, kidney, testis, lung, intestine, spleen) or from any other species (man, monkey, mouse, dog, rabbit, chicken, cow, yeast) examined. During postnatal cardiac development, the expression of the transcript appears to be down-regulated and is present at levels 10-fold greater in neonates than in adults. The function of this retroposon that is expressed in rat heart and liver has not yet been determined, but the sequence analysis of its LTR and its expression pattern suggest that it may be regulated by specific trans-acting factors that are present in both rat heart and liver.
Persistent Identifierhttp://hdl.handle.net/10722/195237
ISSN
2015 Impact Factor: 4.874
2015 SCImago Journal Rankings: 2.522
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorMartin, XJ-
dc.contributor.authorSchwartz, K-
dc.contributor.authorBoheler, KR-
dc.date.accessioned2014-02-25T01:40:20Z-
dc.date.available2014-02-25T01:40:20Z-
dc.date.issued1995-
dc.identifier.citationJournal of Molecular and Cellular Cardiology, 1995, v. 27 n. 1, p. 589-597-
dc.identifier.issn0022-2828-
dc.identifier.urihttp://hdl.handle.net/10722/195237-
dc.description.abstractEleven cDNA clones of retroviral origin (SORO) have been isolated and characterized from a rat cardiac cDNA library that are highly homologous to the RAL-element family of rat retroviral endogenous sequences. SORO-1, the largest of the clones isolated at approximately 3.5 kb, contains a characteristic long terminal repeat (LTR) that is unique to previously identified retroposons. Its LTR contains elements homologous to the CAAT box, a TATA box, a core enhancer sequence, and potential binding sites for GATA. SORO-1 hybridizes to a mRNA of approximately 7 kb, that is present both in rat heart and liver. This transcript was not, however, detected in other tissues (fast and slow skeletal muscles, brain, kidney, testis, lung, intestine, spleen) or from any other species (man, monkey, mouse, dog, rabbit, chicken, cow, yeast) examined. During postnatal cardiac development, the expression of the transcript appears to be down-regulated and is present at levels 10-fold greater in neonates than in adults. The function of this retroposon that is expressed in rat heart and liver has not yet been determined, but the sequence analysis of its LTR and its expression pattern suggest that it may be regulated by specific trans-acting factors that are present in both rat heart and liver.-
dc.languageeng-
dc.relation.ispartofJournal of Molecular and Cellular Cardiology-
dc.titleCharacterization of a novel transcript of retroviral origin expressed in rat heart and liver-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S0022-2828(08)80053-3-
dc.identifier.pmid7760379-
dc.identifier.scopuseid_2-s2.0-0028958459-
dc.identifier.volume27-
dc.identifier.issue1-
dc.identifier.spage589-
dc.identifier.epage597-
dc.identifier.isiWOS:A1995QK48900052-

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