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Conference Paper: Regulation of myosin heavy chain and actin isogenes expression during cardiac growth

TitleRegulation of myosin heavy chain and actin isogenes expression during cardiac growth
Authors
Issue Date1991
Citation
Molecular and Cellular Biochemistry, 1991, v. 104 n. 1-2, p. 101-107 How to Cite?
AbstractThe cardiac ventricular myosin heavy chain phenotype is developmentally and hormonally regulated, but less is known concerning the actin phenotype. In this study, the levels of accumulation of α-skeletal and α-cardiac actin mRNAs were investigated in rat and human ventricles by primer extension assays. In rat, the two iso-mRNAs are present in approximately equal amounts from birth until 15 days of age and the cardiac form is predominant in adult and senescent hearts. Hypothyroid development has no effect, at least during the first two weeks of age. In man, the two isoactins are co-expressed to similar ratios in one control heart and in one failing heart. It therefore appears that myosin heavy chain and actin multigene families are both expressed in a species specific fashion but are independently regulated within a species. Preliminary results from nuclear run-on assays are presented that indicate differences in the level of transcription of the α-actin and β-myosin heavy chain isogenes in the rat heart.
Persistent Identifierhttp://hdl.handle.net/10722/195221
ISSN
2015 Impact Factor: 2.613
2015 SCImago Journal Rankings: 1.019
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorBoheler, KR-
dc.contributor.authorCarrier, L-
dc.contributor.authorChassagne, C-
dc.contributor.authorDe La Bastie, D-
dc.contributor.authorMercadier, JJ-
dc.contributor.authorSchwartz, K-
dc.date.accessioned2014-02-25T01:40:19Z-
dc.date.available2014-02-25T01:40:19Z-
dc.date.issued1991-
dc.identifier.citationMolecular and Cellular Biochemistry, 1991, v. 104 n. 1-2, p. 101-107-
dc.identifier.issn0300-8177-
dc.identifier.urihttp://hdl.handle.net/10722/195221-
dc.description.abstractThe cardiac ventricular myosin heavy chain phenotype is developmentally and hormonally regulated, but less is known concerning the actin phenotype. In this study, the levels of accumulation of α-skeletal and α-cardiac actin mRNAs were investigated in rat and human ventricles by primer extension assays. In rat, the two iso-mRNAs are present in approximately equal amounts from birth until 15 days of age and the cardiac form is predominant in adult and senescent hearts. Hypothyroid development has no effect, at least during the first two weeks of age. In man, the two isoactins are co-expressed to similar ratios in one control heart and in one failing heart. It therefore appears that myosin heavy chain and actin multigene families are both expressed in a species specific fashion but are independently regulated within a species. Preliminary results from nuclear run-on assays are presented that indicate differences in the level of transcription of the α-actin and β-myosin heavy chain isogenes in the rat heart.-
dc.languageeng-
dc.relation.ispartofMolecular and Cellular Biochemistry-
dc.titleRegulation of myosin heavy chain and actin isogenes expression during cardiac growth-
dc.typeConference_Paper-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/BF00229809-
dc.identifier.pmid1833621-
dc.identifier.scopuseid_2-s2.0-0025829658-
dc.identifier.volume104-
dc.identifier.issue1-2-
dc.identifier.spage101-
dc.identifier.epage107-
dc.identifier.isiWOS:A1991FU08500014-

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