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Article: Developmental cues for the maturation of metabolic, electrophysiological and calcium handling properties of human pluripotent stem cell-derived cardiomyocytes

TitleDevelopmental cues for the maturation of metabolic, electrophysiological and calcium handling properties of human pluripotent stem cell-derived cardiomyocytes
Authors
Issue Date2014
PublisherBioMed Central Ltd. The Journal's web site is located at http://www.stemcellres.com
Citation
Stem Cell Research and Therapy, 2014, v. 5 n. 1, article no. 17 How to Cite?
AbstractHuman pluripotent stem cells (hPSCs), including embryonic and induced pluripotent stem cells, are abundant sources of cardiomyocytes (CMs) for cell replacement therapy and other applications such as disease modeling, drug discovery and cardiotoxicity screening. However, hPSC-derived CMs display immature structural, electrophysiological, calcium-handling and metabolic properties. Here, we review various biological as well as physical and topographical cues that are known to associate with the development of native CMs in vivo to gain insights into the development of strategies for facilitated maturation of hPSC-CMs. © 2014 Keung et al.; licensee BioMed Central Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/195210
ISSN
2015 Impact Factor: 4.504
2015 SCImago Journal Rankings: 1.405
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorKeung, W-
dc.contributor.authorBoheler, KR-
dc.contributor.authorLi, RA-
dc.date.accessioned2014-02-25T01:40:18Z-
dc.date.available2014-02-25T01:40:18Z-
dc.date.issued2014-
dc.identifier.citationStem Cell Research and Therapy, 2014, v. 5 n. 1, article no. 17-
dc.identifier.issn1757-6512-
dc.identifier.urihttp://hdl.handle.net/10722/195210-
dc.description.abstractHuman pluripotent stem cells (hPSCs), including embryonic and induced pluripotent stem cells, are abundant sources of cardiomyocytes (CMs) for cell replacement therapy and other applications such as disease modeling, drug discovery and cardiotoxicity screening. However, hPSC-derived CMs display immature structural, electrophysiological, calcium-handling and metabolic properties. Here, we review various biological as well as physical and topographical cues that are known to associate with the development of native CMs in vivo to gain insights into the development of strategies for facilitated maturation of hPSC-CMs. © 2014 Keung et al.; licensee BioMed Central Ltd.-
dc.languageeng-
dc.publisherBioMed Central Ltd. The Journal's web site is located at http://www.stemcellres.com-
dc.relation.ispartofStem Cell Research and Therapy-
dc.rightsStem Cell Research & Therapy. Copyright © BioMed Central Ltd-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleDevelopmental cues for the maturation of metabolic, electrophysiological and calcium handling properties of human pluripotent stem cell-derived cardiomyocytes-
dc.typeArticle-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1186/scrt406-
dc.identifier.pmid24467782-
dc.identifier.pmcidPMC4055054-
dc.identifier.scopuseid_2-s2.0-84893395943-
dc.identifier.hkuros239598-
dc.identifier.volume5-
dc.identifier.issue1-
dc.identifier.isiWOS:000331728200001-

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