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- Publisher Website: 10.1186/scrt406
- Scopus: eid_2-s2.0-84893395943
- PMID: 24467782
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Article: Developmental cues for the maturation of metabolic, electrophysiological and calcium handling properties of human pluripotent stem cell-derived cardiomyocytes
| Title | Developmental cues for the maturation of metabolic, electrophysiological and calcium handling properties of human pluripotent stem cell-derived cardiomyocytes |
|---|---|
| Authors | |
| Issue Date | 2014 |
| Publisher | BioMed Central Ltd. The Journal's web site is located at http://www.stemcellres.com |
| Citation | Stem Cell Research and Therapy, 2014, v. 5 n. 1, article no. 17 How to Cite? |
| Abstract | Human pluripotent stem cells (hPSCs), including embryonic and induced pluripotent stem cells, are abundant sources of cardiomyocytes (CMs) for cell replacement therapy and other applications such as disease modeling, drug discovery and cardiotoxicity screening. However, hPSC-derived CMs display immature structural, electrophysiological, calcium-handling and metabolic properties. Here, we review various biological as well as physical and topographical cues that are known to associate with the development of native CMs in vivo to gain insights into the development of strategies for facilitated maturation of hPSC-CMs. © 2014 Keung et al.; licensee BioMed Central Ltd. |
| Persistent Identifier | http://hdl.handle.net/10722/195210 |
| ISSN | 2021 Impact Factor: 8.079 2020 SCImago Journal Rankings: 1.599 |
| PubMed Central ID | |
| ISI Accession Number ID |
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Keung, W | - |
| dc.contributor.author | Boheler, KR | - |
| dc.contributor.author | Li, RA | - |
| dc.date.accessioned | 2014-02-25T01:40:18Z | - |
| dc.date.available | 2014-02-25T01:40:18Z | - |
| dc.date.issued | 2014 | - |
| dc.identifier.citation | Stem Cell Research and Therapy, 2014, v. 5 n. 1, article no. 17 | - |
| dc.identifier.issn | 1757-6512 | - |
| dc.identifier.uri | http://hdl.handle.net/10722/195210 | - |
| dc.description.abstract | Human pluripotent stem cells (hPSCs), including embryonic and induced pluripotent stem cells, are abundant sources of cardiomyocytes (CMs) for cell replacement therapy and other applications such as disease modeling, drug discovery and cardiotoxicity screening. However, hPSC-derived CMs display immature structural, electrophysiological, calcium-handling and metabolic properties. Here, we review various biological as well as physical and topographical cues that are known to associate with the development of native CMs in vivo to gain insights into the development of strategies for facilitated maturation of hPSC-CMs. © 2014 Keung et al.; licensee BioMed Central Ltd. | - |
| dc.language | eng | - |
| dc.publisher | BioMed Central Ltd. The Journal's web site is located at http://www.stemcellres.com | - |
| dc.relation.ispartof | Stem Cell Research and Therapy | - |
| dc.rights | Stem Cell Research & Therapy. Copyright © BioMed Central Ltd | - |
| dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
| dc.title | Developmental cues for the maturation of metabolic, electrophysiological and calcium handling properties of human pluripotent stem cell-derived cardiomyocytes | - |
| dc.type | Article | - |
| dc.description.nature | published_or_final_version | - |
| dc.identifier.doi | 10.1186/scrt406 | - |
| dc.identifier.pmid | 24467782 | - |
| dc.identifier.pmcid | PMC4055054 | - |
| dc.identifier.scopus | eid_2-s2.0-84893395943 | - |
| dc.identifier.hkuros | 239598 | - |
| dc.identifier.volume | 5 | - |
| dc.identifier.issue | 1 | - |
| dc.identifier.isi | WOS:000331728200001 | - |
| dc.identifier.issnl | 1757-6512 | - |