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Article: Corneal changes after a single session of selective laser trabeculoplasty for open-angle glaucoma

TitleCorneal changes after a single session of selective laser trabeculoplasty for open-angle glaucoma
Authors
Issue Date2014
Citation
Eye (Basingstoke), 2014, v. 28 n. 1, p. 47-52 How to Cite?
AbstractPurposeTo investigate the changes in endothelial cell count, central corneal thickness (CCT), and refractive error after a session of selective laser trabeculoplasty (SLT) for open angle glaucoma (OAG).MethodsThis prospective cohort study recruited 111 eyes of 66 consecutive subjects with OAG. Subjects received SLT to 360° of the trabecular meshwork. Endothelial cell count, CCT, and spherical equivalent were measured at baseline before SLT as well as at 1 week and 1 month post SLT. A repeated measure nested ANOVA with Tukey's multiple comparison test was performed to compare the outcome measures before and after SLT.ResultsIn 111 eyes of 66 subjects, the mean number of laser applications per treatment was 166.9±41.4 with a mean energy level of 1.0±0.07 mJ. The mean endothelial cell count decreased significantly from 2465.0±334.0 cells/mm 2 at baseline to 2355.0±387.0 cells/mm 2 at 1 week (P=0.0004) but increased to baseline levels at 1 month post SLT (2424.0±379.4 cells/mm 2, P=0.3). The CCT, which decreased from a baseline of 549.4±37.6 to 543.9±40.2 μm at 1 week post SLT (P=0.02), also returned to the baseline level by 1 month (P=0.2). The spherical equivalent was static from baseline. A positive correlation was found between total laser energy and CCT at 1 month post treatment (r=0.3, P=0.005).ConclusionThe transient reductions in endothelial cell count and CCT following SLT returned to baseline levels 1 month after the procedure. Patients undergoing SLT should be aware of the risk of potential corneal changes. © 2014 Macmillan Publishers Limited All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/195209
ISSN
2015 Impact Factor: 2.213
2015 SCImago Journal Rankings: 1.132
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLee, JWY-
dc.contributor.authorChan, JCH-
dc.contributor.authorChang, RT-
dc.contributor.authorSingh, K-
dc.contributor.authorLiu, CCL-
dc.contributor.authorGangwani, R-
dc.contributor.authorWong, MOM-
dc.contributor.authorLai, JSM-
dc.date.accessioned2014-02-25T01:40:18Z-
dc.date.available2014-02-25T01:40:18Z-
dc.date.issued2014-
dc.identifier.citationEye (Basingstoke), 2014, v. 28 n. 1, p. 47-52-
dc.identifier.issn0950-222X-
dc.identifier.urihttp://hdl.handle.net/10722/195209-
dc.description.abstractPurposeTo investigate the changes in endothelial cell count, central corneal thickness (CCT), and refractive error after a session of selective laser trabeculoplasty (SLT) for open angle glaucoma (OAG).MethodsThis prospective cohort study recruited 111 eyes of 66 consecutive subjects with OAG. Subjects received SLT to 360° of the trabecular meshwork. Endothelial cell count, CCT, and spherical equivalent were measured at baseline before SLT as well as at 1 week and 1 month post SLT. A repeated measure nested ANOVA with Tukey's multiple comparison test was performed to compare the outcome measures before and after SLT.ResultsIn 111 eyes of 66 subjects, the mean number of laser applications per treatment was 166.9±41.4 with a mean energy level of 1.0±0.07 mJ. The mean endothelial cell count decreased significantly from 2465.0±334.0 cells/mm 2 at baseline to 2355.0±387.0 cells/mm 2 at 1 week (P=0.0004) but increased to baseline levels at 1 month post SLT (2424.0±379.4 cells/mm 2, P=0.3). The CCT, which decreased from a baseline of 549.4±37.6 to 543.9±40.2 μm at 1 week post SLT (P=0.02), also returned to the baseline level by 1 month (P=0.2). The spherical equivalent was static from baseline. A positive correlation was found between total laser energy and CCT at 1 month post treatment (r=0.3, P=0.005).ConclusionThe transient reductions in endothelial cell count and CCT following SLT returned to baseline levels 1 month after the procedure. Patients undergoing SLT should be aware of the risk of potential corneal changes. © 2014 Macmillan Publishers Limited All rights reserved.-
dc.languageeng-
dc.relation.ispartofEye (Basingstoke)-
dc.titleCorneal changes after a single session of selective laser trabeculoplasty for open-angle glaucoma-
dc.typeArticle-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1038/eye.2013.231-
dc.identifier.pmid24136571-
dc.identifier.pmcidPMC3890760-
dc.identifier.scopuseid_2-s2.0-84891907828-
dc.identifier.hkuros234690-
dc.identifier.hkuros234688-
dc.identifier.volume28-
dc.identifier.issue1-
dc.identifier.spage47-
dc.identifier.epage52-
dc.identifier.isiWOS:000329440100008-

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