File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Embryonic stem cells: Prospects for developmental biology and cell therapy

TitleEmbryonic stem cells: Prospects for developmental biology and cell therapy
Authors
Issue Date2005
Citation
Physiological Reviews, 2005, v. 85 n. 2, p. 635-678 How to Cite?
AbstractStem cells represent natural units of embryonic development and tissue regeneration. Embryonic stem (ES) cells, in particular, possess a nearly unlimited self-renewal capacity and developmental potential to differentiate into virtually any cell type of an organism. Mouse ES cells, which are established as permanent cell lines from early embryos, can be regarded as a versatile biological system that has led to major advances in cell and developmental biology. Human ES cell lines, which have recently been derived, may additionally serve as an unlimited source of cells for regenerative medicine. Before therapeutic applications can be realized, important problems must be resolved. Ethical issues surround the derivation of human ES cells from in vitro fertilized blastocysts. Current techniques for directed differentiation into somatic cell populations remain inefficient and yield heterogeneous cell populations. Transplanted ES cell progeny may not function normally in organs, might retain tumorigenic potential, and could be rejected immunologically. The number of human ES cell lines available for research may also be insufficient to adequately determine their therapeutic potential. Recent molecular and cellular advances with mouse ES cells, however, portend the successful use of these cells in therapeutics. This review therefore focuses both on mouse and human ES cells with respect to in vitro propagation and differentiation as well as their use in basic cell and developmental biology and toxicology and presents prospects for human ES cells in tissue regeneration and transplantation. Copyright © 2005 the American Physiological Society.
Persistent Identifierhttp://hdl.handle.net/10722/195172
ISSN
2015 Impact Factor: 30.924
2015 SCImago Journal Rankings: 17.564
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWobus, AM-
dc.contributor.authorBoheler, KR-
dc.date.accessioned2014-02-25T01:40:16Z-
dc.date.available2014-02-25T01:40:16Z-
dc.date.issued2005-
dc.identifier.citationPhysiological Reviews, 2005, v. 85 n. 2, p. 635-678-
dc.identifier.issn0031-9333-
dc.identifier.urihttp://hdl.handle.net/10722/195172-
dc.description.abstractStem cells represent natural units of embryonic development and tissue regeneration. Embryonic stem (ES) cells, in particular, possess a nearly unlimited self-renewal capacity and developmental potential to differentiate into virtually any cell type of an organism. Mouse ES cells, which are established as permanent cell lines from early embryos, can be regarded as a versatile biological system that has led to major advances in cell and developmental biology. Human ES cell lines, which have recently been derived, may additionally serve as an unlimited source of cells for regenerative medicine. Before therapeutic applications can be realized, important problems must be resolved. Ethical issues surround the derivation of human ES cells from in vitro fertilized blastocysts. Current techniques for directed differentiation into somatic cell populations remain inefficient and yield heterogeneous cell populations. Transplanted ES cell progeny may not function normally in organs, might retain tumorigenic potential, and could be rejected immunologically. The number of human ES cell lines available for research may also be insufficient to adequately determine their therapeutic potential. Recent molecular and cellular advances with mouse ES cells, however, portend the successful use of these cells in therapeutics. This review therefore focuses both on mouse and human ES cells with respect to in vitro propagation and differentiation as well as their use in basic cell and developmental biology and toxicology and presents prospects for human ES cells in tissue regeneration and transplantation. Copyright © 2005 the American Physiological Society.-
dc.languageeng-
dc.relation.ispartofPhysiological Reviews-
dc.titleEmbryonic stem cells: Prospects for developmental biology and cell therapy-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1152/physrev.00054.2003-
dc.identifier.pmid15788707-
dc.identifier.scopuseid_2-s2.0-15544383394-
dc.identifier.volume85-
dc.identifier.issue2-
dc.identifier.spage635-
dc.identifier.epage678-
dc.identifier.isiWOS:000227854700005-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats