File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Pluripotent stem cell heterogeneity and the evolving role of proteomic technologies in stem cell biology

TitlePluripotent stem cell heterogeneity and the evolving role of proteomic technologies in stem cell biology
Authors
Issue Date2011
Citation
Proteomics, 2011, v. 11 n. 20, p. 3947-3961 How to Cite?
AbstractStem cells represent obvious choices for regenerative medicine and are invaluable for studies of human development and drug testing. The proteomic landscape of pluripotent stem cells (PSCs), in particular, is not yet clearly defined; consequently, this field of research would greatly benefit from concerted efforts designed to better characterize these cells. In this concise review, we provide an overview of stem cell potency, highlight the types and practical implications of heterogeneity in PSCs and provide a detailed analysis of the current view of the pluripotent proteome in a unique resource for this rapidly evolving field. Our goal in this review is to provide specific insights into the current status of the known proteome of both mouse and human PSCs. This has been accomplished by integrating published data into a unified PSC proteome to facilitate the identification of proteins, which may be informative for the stem cell state as well as to reveal areas where our current view is limited. These analyses provide insight into the challenges faced in the proteomic analysis of PSCs and reveal one area - the cell surface subproteome - that would especially benefit from enhanced research efforts. © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Persistent Identifierhttp://hdl.handle.net/10722/195141
ISSN
2015 Impact Factor: 4.079
2015 SCImago Journal Rankings: 1.476
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorGundry, RL-
dc.contributor.authorBurridge, PW-
dc.contributor.authorBoheler, KR-
dc.date.accessioned2014-02-25T01:40:13Z-
dc.date.available2014-02-25T01:40:13Z-
dc.date.issued2011-
dc.identifier.citationProteomics, 2011, v. 11 n. 20, p. 3947-3961-
dc.identifier.issn1615-9853-
dc.identifier.urihttp://hdl.handle.net/10722/195141-
dc.description.abstractStem cells represent obvious choices for regenerative medicine and are invaluable for studies of human development and drug testing. The proteomic landscape of pluripotent stem cells (PSCs), in particular, is not yet clearly defined; consequently, this field of research would greatly benefit from concerted efforts designed to better characterize these cells. In this concise review, we provide an overview of stem cell potency, highlight the types and practical implications of heterogeneity in PSCs and provide a detailed analysis of the current view of the pluripotent proteome in a unique resource for this rapidly evolving field. Our goal in this review is to provide specific insights into the current status of the known proteome of both mouse and human PSCs. This has been accomplished by integrating published data into a unified PSC proteome to facilitate the identification of proteins, which may be informative for the stem cell state as well as to reveal areas where our current view is limited. These analyses provide insight into the challenges faced in the proteomic analysis of PSCs and reveal one area - the cell surface subproteome - that would especially benefit from enhanced research efforts. © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.-
dc.languageeng-
dc.relation.ispartofProteomics-
dc.titlePluripotent stem cell heterogeneity and the evolving role of proteomic technologies in stem cell biology-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/pmic.201100100-
dc.identifier.pmid21834136-
dc.identifier.scopuseid_2-s2.0-80054006441-
dc.identifier.volume11-
dc.identifier.issue20-
dc.identifier.spage3947-
dc.identifier.epage3961-
dc.identifier.isiWOS:000296491800002-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats