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Article: Nestin expression - A property of multi-lineage progenitor cells?

TitleNestin expression - A property of multi-lineage progenitor cells?
Authors
Issue Date2004
Citation
Cellular and Molecular Life Sciences, 2004, v. 61 n. 19-20, p. 2510-2522 How to Cite?
AbstractTissue-specific progenitor cells are characterized by proliferation and differentiation, but, in contrast to embryonic stem (ES) cells, have limited capacities for self-renewal and no tumourigenic potential. These latter traits make progenitor cells an ideal source for regenerative cell therapies. In this review, we describe what is currently known about nestin, an intermediate filament first identified in neuroepithelial stem cells. During embryogenesis, nestin is expressed in migrating and proliferating cells, whereas in adult tissues, nestin is mainly restricted to areas of regeneration. We show that nestin is abundant in ES-derived progenitor cells that have the potential to develop into neuroectodermal, endodermal and mesodermal lineages. Although it remains unclear what factors regulate in vitro and in vivo expression of nestin, we conclude that nestin represents a characteristic marker of multi-lineage progenitor cells and suggest that its presence in cells may indicate multi-potentiality and regenerative potential.
Persistent Identifierhttp://hdl.handle.net/10722/195130
ISSN
2015 Impact Factor: 5.694
2015 SCImago Journal Rankings: 3.388
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWiese, C-
dc.contributor.authorRolletschek, A-
dc.contributor.authorKania, G-
dc.contributor.authorBlyszczuk, P-
dc.contributor.authorTarasov, KV-
dc.contributor.authorTarasova, Y-
dc.contributor.authorWersto, RP-
dc.contributor.authorBoheler, KR-
dc.contributor.authorWobus, AM-
dc.date.accessioned2014-02-25T01:40:12Z-
dc.date.available2014-02-25T01:40:12Z-
dc.date.issued2004-
dc.identifier.citationCellular and Molecular Life Sciences, 2004, v. 61 n. 19-20, p. 2510-2522-
dc.identifier.issn1420-682X-
dc.identifier.urihttp://hdl.handle.net/10722/195130-
dc.description.abstractTissue-specific progenitor cells are characterized by proliferation and differentiation, but, in contrast to embryonic stem (ES) cells, have limited capacities for self-renewal and no tumourigenic potential. These latter traits make progenitor cells an ideal source for regenerative cell therapies. In this review, we describe what is currently known about nestin, an intermediate filament first identified in neuroepithelial stem cells. During embryogenesis, nestin is expressed in migrating and proliferating cells, whereas in adult tissues, nestin is mainly restricted to areas of regeneration. We show that nestin is abundant in ES-derived progenitor cells that have the potential to develop into neuroectodermal, endodermal and mesodermal lineages. Although it remains unclear what factors regulate in vitro and in vivo expression of nestin, we conclude that nestin represents a characteristic marker of multi-lineage progenitor cells and suggest that its presence in cells may indicate multi-potentiality and regenerative potential.-
dc.languageeng-
dc.relation.ispartofCellular and Molecular Life Sciences-
dc.titleNestin expression - A property of multi-lineage progenitor cells?-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/s00018-004-4144-6-
dc.identifier.pmid15526158-
dc.identifier.scopuseid_2-s2.0-8344220136-
dc.identifier.volume61-
dc.identifier.issue19-20-
dc.identifier.spage2510-
dc.identifier.epage2522-
dc.identifier.isiWOS:000224888600010-

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