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Article: Pluripotency of human embryonic and induced pluripotent stem cells for cardiac and vascular regeneration

TitlePluripotency of human embryonic and induced pluripotent stem cells for cardiac and vascular regeneration
Authors
Issue Date2010
Citation
Thrombosis and Haemostasis, 2010, v. 104 n. 1, p. 23-29 How to Cite?
AbstractCardiac and vascular abnormalities and disease syndromes are major causes of death both during human development and with aging. To identify the cause of congenital defects and to combat this epidemic in the aging population, new models must be created for scientific investigation and new therapies must be developed. Recent advances in pluripotent stem cell biology offer renewed hope for tackling these problems. Of particular importance has been the creation of induced pluripotent (iPS) cells from adult tissues and organs through the forced expression of two to four transcription factors. Moreover, iPS cells, which are phenotypically indistinguishable from embryonic stem (ES) cells, can be generated from any patient. This unique capacity when coupled with samples from patients who have congenital and genetic defects of unknown aetiology should permit the creation of new model systems that foment scientific investigation. Moreover, creation of patient-specific cells should overcome many of the immunological limitations that currently impede therapeutic applications associated with other pluripotent stem cells and their derivatives. The aims of this paper will be to discuss cardiac and vascular diseases and show how iPS cells may be employed to overcome some of the most significant scientific and clinical hurdles facing this field. © Schattauer 2010.
Persistent Identifierhttp://hdl.handle.net/10722/195126
ISSN
2015 Impact Factor: 5.255
2015 SCImago Journal Rankings: 2.089
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorBoheler, KR-
dc.date.accessioned2014-02-25T01:40:12Z-
dc.date.available2014-02-25T01:40:12Z-
dc.date.issued2010-
dc.identifier.citationThrombosis and Haemostasis, 2010, v. 104 n. 1, p. 23-29-
dc.identifier.issn0340-6245-
dc.identifier.urihttp://hdl.handle.net/10722/195126-
dc.description.abstractCardiac and vascular abnormalities and disease syndromes are major causes of death both during human development and with aging. To identify the cause of congenital defects and to combat this epidemic in the aging population, new models must be created for scientific investigation and new therapies must be developed. Recent advances in pluripotent stem cell biology offer renewed hope for tackling these problems. Of particular importance has been the creation of induced pluripotent (iPS) cells from adult tissues and organs through the forced expression of two to four transcription factors. Moreover, iPS cells, which are phenotypically indistinguishable from embryonic stem (ES) cells, can be generated from any patient. This unique capacity when coupled with samples from patients who have congenital and genetic defects of unknown aetiology should permit the creation of new model systems that foment scientific investigation. Moreover, creation of patient-specific cells should overcome many of the immunological limitations that currently impede therapeutic applications associated with other pluripotent stem cells and their derivatives. The aims of this paper will be to discuss cardiac and vascular diseases and show how iPS cells may be employed to overcome some of the most significant scientific and clinical hurdles facing this field. © Schattauer 2010.-
dc.languageeng-
dc.relation.ispartofThrombosis and Haemostasis-
dc.titlePluripotency of human embryonic and induced pluripotent stem cells for cardiac and vascular regeneration-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1160/TH09-07-0507-
dc.identifier.pmid20458433-
dc.identifier.scopuseid_2-s2.0-77954353258-
dc.identifier.volume104-
dc.identifier.issue1-
dc.identifier.spage23-
dc.identifier.epage29-
dc.identifier.isiWOS:000280298300005-

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