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Article: Functional disruption of HypB, a GTPase of Helicobacter pylori, by bismuth

TitleFunctional disruption of HypB, a GTPase of Helicobacter pylori, by bismuth
Authors
Issue Date2014
PublisherRoyal Society of Chemistry. The Journal's web site is located at http://www.rsc.org/Publishing/Journals/cc/index.asp
Citation
Chemical Communications, 2014, v. 50 n. 13, p. 1161-1164 How to Cite?
AbstractBismuth (Bi3+) binds equal molar amounts of HypB from Helicobacter pylori at the conserved metal site with a dissociation constant of 0.94 (0.25)x10(-17) uM, and concomitantly induces the protein dimerization similarly to Ni2+. Excess Bi3+ causes HypB further oligomerization, leading to HypB GTPase dysfunction. The results extend our understanding on the inhibitory mechanism of bismuth drugs against the pathogen.
Persistent Identifierhttp://hdl.handle.net/10722/194672
ISSN
2015 Impact Factor: 6.567
2015 SCImago Journal Rankings: 2.771
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorXia, Wen_US
dc.contributor.authorLi, Hen_US
dc.contributor.authorSun, Hen_US
dc.date.accessioned2014-02-17T02:02:41Z-
dc.date.available2014-02-17T02:02:41Z-
dc.date.issued2014en_US
dc.identifier.citationChemical Communications, 2014, v. 50 n. 13, p. 1161-1164en_US
dc.identifier.issn1359-7345en_US
dc.identifier.urihttp://hdl.handle.net/10722/194672-
dc.description.abstractBismuth (Bi3+) binds equal molar amounts of HypB from <i>Helicobacter pylori</i> at the conserved metal site with a dissociation constant of 0.94 (0.25)x10(-17) uM, and concomitantly induces the protein dimerization similarly to Ni2+. Excess Bi3+ causes HypB further oligomerization, leading to HypB GTPase dysfunction. The results extend our understanding on the inhibitory mechanism of bismuth drugs against the pathogen.en_US
dc.languageengen_US
dc.publisherRoyal Society of Chemistry. The Journal's web site is located at http://www.rsc.org/Publishing/Journals/cc/index.aspen_US
dc.relation.ispartofChemical Communicationsen_US
dc.titleFunctional disruption of HypB, a GTPase of Helicobacter pylori, by bismuthen_US
dc.typeArticleen_US
dc.identifier.emailXia, W: weixia1984@hku.hken_US
dc.identifier.emailLi, H: hylichem@hku.hken_US
dc.identifier.emailSun, H: hsun@hku.hken_US
dc.identifier.authoritySun, H=rp00777en_US
dc.identifier.doi10.1039/c3cc47644h-
dc.identifier.pmid24389922-
dc.identifier.scopuseid_2-s2.0-84892641016-
dc.identifier.hkuros227913en_US
dc.identifier.volume50en_US
dc.identifier.issue13en_US
dc.identifier.spage1161en_US
dc.identifier.epage1164en_US
dc.identifier.isiWOS:000329991700031-
dc.publisher.placeUnited Kingdomen_US

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