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- Publisher Website: 10.1039/c3cc47644h
- Scopus: eid_2-s2.0-84892641016
- PMID: 24389922
- WOS: WOS:000329991700031
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Article: Functional disruption of HypB, a GTPase of Helicobacter pylori, by bismuth
Title | Functional disruption of HypB, a GTPase of Helicobacter pylori, by bismuth |
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Authors | |
Issue Date | 2014 |
Publisher | Royal Society of Chemistry. The Journal's web site is located at http://www.rsc.org/Publishing/Journals/cc/index.asp |
Citation | Chemical Communications, 2014, v. 50 n. 13, p. 1161-1164 How to Cite? |
Abstract | Bismuth (Bi3+) binds equal molar amounts of HypB from Helicobacter pylori at the conserved metal site with a dissociation constant of 0.94 (0.25)x10(-17) uM, and concomitantly induces the protein dimerization similarly to Ni2+. Excess Bi3+ causes HypB further oligomerization, leading to HypB GTPase dysfunction. The results extend our understanding on the inhibitory mechanism of bismuth drugs against the pathogen. |
Persistent Identifier | http://hdl.handle.net/10722/194672 |
ISSN | 2023 Impact Factor: 4.3 2023 SCImago Journal Rankings: 1.133 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Xia, W | en_US |
dc.contributor.author | Li, H | en_US |
dc.contributor.author | Sun, H | en_US |
dc.date.accessioned | 2014-02-17T02:02:41Z | - |
dc.date.available | 2014-02-17T02:02:41Z | - |
dc.date.issued | 2014 | en_US |
dc.identifier.citation | Chemical Communications, 2014, v. 50 n. 13, p. 1161-1164 | en_US |
dc.identifier.issn | 1359-7345 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/194672 | - |
dc.description.abstract | Bismuth (Bi3+) binds equal molar amounts of HypB from <i>Helicobacter pylori</i> at the conserved metal site with a dissociation constant of 0.94 (0.25)x10(-17) uM, and concomitantly induces the protein dimerization similarly to Ni2+. Excess Bi3+ causes HypB further oligomerization, leading to HypB GTPase dysfunction. The results extend our understanding on the inhibitory mechanism of bismuth drugs against the pathogen. | en_US |
dc.language | eng | en_US |
dc.publisher | Royal Society of Chemistry. The Journal's web site is located at http://www.rsc.org/Publishing/Journals/cc/index.asp | en_US |
dc.relation.ispartof | Chemical Communications | en_US |
dc.title | Functional disruption of HypB, a GTPase of Helicobacter pylori, by bismuth | en_US |
dc.type | Article | en_US |
dc.identifier.email | Xia, W: weixia1984@hku.hk | en_US |
dc.identifier.email | Li, H: hylichem@hku.hk | en_US |
dc.identifier.email | Sun, H: hsun@hku.hk | en_US |
dc.identifier.authority | Sun, H=rp00777 | en_US |
dc.identifier.doi | 10.1039/c3cc47644h | - |
dc.identifier.pmid | 24389922 | - |
dc.identifier.scopus | eid_2-s2.0-84892641016 | - |
dc.identifier.hkuros | 227913 | en_US |
dc.identifier.volume | 50 | en_US |
dc.identifier.issue | 13 | en_US |
dc.identifier.spage | 1161 | en_US |
dc.identifier.epage | 1164 | en_US |
dc.identifier.isi | WOS:000329991700031 | - |
dc.publisher.place | United Kingdom | en_US |
dc.identifier.issnl | 1359-7345 | - |