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Article: MDM2 and MDMX can interact differently with ARF and members of the p53 family

TitleMDM2 and MDMX can interact differently with ARF and members of the p53 family
Authors
Issue Date2001
PublisherElsevier BV.
Citation
FEBS Letters, 2001, v. 490 n. 3, p. 202-208 How to Cite?
AbstractMembers of the p53 family of transcription factors have essential roles in tumor suppression and in development. MDM2 is an essential regulator of p53 that can inhibit the transcriptional activity of p53, shuttle p53 out of the nucleus, and target p53 for ubiquitination-mediated degradation. Little is known about the interaction and selectivity of different members of the p53 family (p53, p63, and p73) and the MDM2 family (MDM2 and MDMX). Here we show that the transcriptional activities of p53 and p73, but not that of p63, were inhibited by both MDM2 and MDMX. Consistent with these, we found that MDMX can physically interact with p53 and p73, but not with p63. Moreover, ectopically expressed MDM2 and MDMX could induce alterations in the subcellular localization of p73, but did not affect the subcellular localization of p53 and p63. Finally, we demonstrate that while ARF can interact with MDM2 and inhibit the regulation of p53 by MDM2, no interaction was found between ARF and MDMX. These data reveal that significant differences and selectivity exist between the regulation of different members of the p53 family by MDM2 and MDMX.
Persistent Identifierhttp://hdl.handle.net/10722/194591
ISSN
2015 Impact Factor: 3.519
2015 SCImago Journal Rankings: 2.026
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWang, X-
dc.contributor.authorArooz, T-
dc.contributor.authorSiu, WY-
dc.contributor.authorChiu, CHS-
dc.contributor.authorLau, A-
dc.contributor.authorYamashita, K-
dc.contributor.authorPoon, RYC-
dc.date.accessioned2014-02-13T04:36:34Z-
dc.date.available2014-02-13T04:36:34Z-
dc.date.issued2001-
dc.identifier.citationFEBS Letters, 2001, v. 490 n. 3, p. 202-208-
dc.identifier.issn0014-5793-
dc.identifier.urihttp://hdl.handle.net/10722/194591-
dc.description.abstractMembers of the p53 family of transcription factors have essential roles in tumor suppression and in development. MDM2 is an essential regulator of p53 that can inhibit the transcriptional activity of p53, shuttle p53 out of the nucleus, and target p53 for ubiquitination-mediated degradation. Little is known about the interaction and selectivity of different members of the p53 family (p53, p63, and p73) and the MDM2 family (MDM2 and MDMX). Here we show that the transcriptional activities of p53 and p73, but not that of p63, were inhibited by both MDM2 and MDMX. Consistent with these, we found that MDMX can physically interact with p53 and p73, but not with p63. Moreover, ectopically expressed MDM2 and MDMX could induce alterations in the subcellular localization of p73, but did not affect the subcellular localization of p53 and p63. Finally, we demonstrate that while ARF can interact with MDM2 and inhibit the regulation of p53 by MDM2, no interaction was found between ARF and MDMX. These data reveal that significant differences and selectivity exist between the regulation of different members of the p53 family by MDM2 and MDMX.-
dc.languageeng-
dc.publisherElsevier BV.-
dc.relation.ispartofFEBS Letters-
dc.rightsNOTICE: this is the author’s version of a work that was accepted for publication in FEBS Letters. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in FEBS Letters, [VOL 490, ISSUE 3, 2001] DOI 10.1016/S0014-5793(01)02124-X-
dc.subject.meshADP-Ribosylation Factors - metabolism-
dc.subject.meshDNA-Binding Proteins - antagonists and inhibitors - genetics - metabolism-
dc.subject.meshMembrane Proteins-
dc.subject.meshNuclear Proteins - antagonists and inhibitors - genetics - metabolism-
dc.subject.meshPhosphoproteins - genetics - metabolism-
dc.titleMDM2 and MDMX can interact differently with ARF and members of the p53 familyen_US
dc.typeArticleen_US
dc.identifier.emailWang, X: xqwang@hkucc.hku.hk-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S0014-5793(01)02124-X-
dc.identifier.pmid11223036-
dc.identifier.scopuseid_2-s2.0-0035895602-
dc.identifier.volume490-
dc.identifier.issue3-
dc.identifier.spage202-
dc.identifier.epage208-
dc.identifier.isiWOS:000167275000013-
dc.publisher.placeNetherlands-

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