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Article: IL-6 is a predictive biomarker for stroke associated infection and future mortality in the elderly after an ischemic stroke

TitleIL-6 is a predictive biomarker for stroke associated infection and future mortality in the elderly after an ischemic stroke
Authors
Issue Date2013
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/expgero
Citation
Experimental Gerontology, 2013, v. 48 n. 9, p. 960-965 How to Cite?
AbstractBACKGROUND AND PURPOSE: Stroke associated infection (within the first seven days) occurs in approximately half of stroke patients and is associated with a worse prognosis, especially in the elderly. It is uncertain what factors predict stroke associated infection, yet identification of a suitable biomarker for infection may allow early and appropriate intervention with antibiotics. The aims of this study were to: a) identify independent risk factors for stroke associated infection, and b) test relationships between these risk factors and mortality at 2 years. METHODS: Eight-two elderly patients were assessed within 72 h of stroke. Data on stroke severity (Barthel Index), stroke associated infection and mortality at 2 years were collected. Inflammatory biomarkers at baseline and 6 months were measured by ELISA. Logistic regression was used to identify risk factors for stroke associated infection and death. RESULTS: Patients with stroke associated infection, especially pneumonia, had increased IL-6, more severe strokes, and higher mortality. IL-6 was independently associated with stroke associated infection (OR = 19.2, [95%CI 3.68, 100], p < 0.001), after adjustment for other risk factors and cytokines. IL-6 was also independently associated with 2 year mortality (OR = 9.2, [1.0, 85.1], p = 0.031). CONCLUSIONS: These data suggest that IL-6 may be a key biomarker for predicting stroke associated infection and mortality in the first two years post stroke.
Persistent Identifierhttp://hdl.handle.net/10722/194538
ISSN
2015 Impact Factor: 3.35
2015 SCImago Journal Rankings: 1.620
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorKwan, SKJ-
dc.contributor.authorHorsfield, G-
dc.contributor.authorBryant, T-
dc.contributor.authorGawne-Cain, M-
dc.contributor.authorDurward, G-
dc.contributor.authorByrne, CD-
dc.contributor.authorEnglyst, NA-
dc.date.accessioned2014-02-07T01:57:13Z-
dc.date.available2014-02-07T01:57:13Z-
dc.date.issued2013-
dc.identifier.citationExperimental Gerontology, 2013, v. 48 n. 9, p. 960-965-
dc.identifier.issn0531-5565-
dc.identifier.urihttp://hdl.handle.net/10722/194538-
dc.description.abstractBACKGROUND AND PURPOSE: Stroke associated infection (within the first seven days) occurs in approximately half of stroke patients and is associated with a worse prognosis, especially in the elderly. It is uncertain what factors predict stroke associated infection, yet identification of a suitable biomarker for infection may allow early and appropriate intervention with antibiotics. The aims of this study were to: a) identify independent risk factors for stroke associated infection, and b) test relationships between these risk factors and mortality at 2 years. METHODS: Eight-two elderly patients were assessed within 72 h of stroke. Data on stroke severity (Barthel Index), stroke associated infection and mortality at 2 years were collected. Inflammatory biomarkers at baseline and 6 months were measured by ELISA. Logistic regression was used to identify risk factors for stroke associated infection and death. RESULTS: Patients with stroke associated infection, especially pneumonia, had increased IL-6, more severe strokes, and higher mortality. IL-6 was independently associated with stroke associated infection (OR = 19.2, [95%CI 3.68, 100], p < 0.001), after adjustment for other risk factors and cytokines. IL-6 was also independently associated with 2 year mortality (OR = 9.2, [1.0, 85.1], p = 0.031). CONCLUSIONS: These data suggest that IL-6 may be a key biomarker for predicting stroke associated infection and mortality in the first two years post stroke.-
dc.languageeng-
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/expgero-
dc.relation.ispartofExperimental Gerontology-
dc.titleIL-6 is a predictive biomarker for stroke associated infection and future mortality in the elderly after an ischemic strokeen_US
dc.typeArticleen_US
dc.identifier.emailKwan, SKJ: jskkwan@hku.hk-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.exger.2013.07.003-
dc.identifier.pmid23872300-
dc.identifier.hkuros227904-
dc.identifier.volume48-
dc.identifier.issue9-
dc.identifier.spage960-
dc.identifier.epage965-
dc.identifier.isiWOS:000323604300014-
dc.publisher.placeUnited States-

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