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Article: Increased monocyte adhesion to aortic endothelium in rats with hyperhomocysteinemia: Role of chemokine and adhesion molecules

TitleIncreased monocyte adhesion to aortic endothelium in rats with hyperhomocysteinemia: Role of chemokine and adhesion molecules
Authors
Issue Date2002
Citation
Arteriosclerosis, Thrombosis, and Vascular Biology, 2002, v. 22 n. 11, p. 1777-1783 How to Cite?
AbstractObjective - The stimulatory effect of homocysteine (Hcy) on monocyte chemoattractant protein (MCP)-1 expression in vitro has been suggested to play an important role in Hcy-mediated atherosclerosis. We investigated whether such a stimulatory effect occurs in vivo, leading to monocyte adhesion to the endothelium. Methods and Results - Sprague-Dawley rats were divided into 4 groups. Hyperhomocysteinemia was induced in 1 group of rats after 4 weeks of a high-methionine diet (serum Hcy levels were 4- to 5-fold higher than levels in control rats). The number of ED-1-positive cells present on the surface of aortic endothelium was significantly elevated in hyperhomocysteinemic rats. There was a significant increase in the expression of MCP-1, vascular cell adhesion molecule-1 (VCAM-1), and E-selectin in the endothelium. Antibodies recognizing MCP-1, VCAM-1, or E-selectin could abolish the enhanced monocyte binding to the aortic endothelium of hyperhomocysteinemic rats. Endothelium-dependent aortic relaxation was impaired in hyperhomocysteinemic rats. Conclusions - These results suggest that in the absence of other known risk factors, hyperhomocysteinemia stimulates the expression of MCP-1, VCAM-1, and E-selectin in vivo, leading to increased monocyte adhesion to the aortic endothelium. Such an effect may contribute significantly to the development of atherosclerosis by facilitating monocyte/macrophage infiltration into the arterial wall.
Persistent Identifierhttp://hdl.handle.net/10722/194502
ISSN
2015 Impact Factor: 5.969
2015 SCImago Journal Rankings: 3.356
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWang, G-
dc.contributor.authorWoo, CWH-
dc.contributor.authorSung, FL-
dc.contributor.authorSiow, YL-
dc.contributor.authorO, K-
dc.date.accessioned2014-01-30T03:32:40Z-
dc.date.available2014-01-30T03:32:40Z-
dc.date.issued2002-
dc.identifier.citationArteriosclerosis, Thrombosis, and Vascular Biology, 2002, v. 22 n. 11, p. 1777-1783-
dc.identifier.issn1079-5642-
dc.identifier.urihttp://hdl.handle.net/10722/194502-
dc.description.abstractObjective - The stimulatory effect of homocysteine (Hcy) on monocyte chemoattractant protein (MCP)-1 expression in vitro has been suggested to play an important role in Hcy-mediated atherosclerosis. We investigated whether such a stimulatory effect occurs in vivo, leading to monocyte adhesion to the endothelium. Methods and Results - Sprague-Dawley rats were divided into 4 groups. Hyperhomocysteinemia was induced in 1 group of rats after 4 weeks of a high-methionine diet (serum Hcy levels were 4- to 5-fold higher than levels in control rats). The number of ED-1-positive cells present on the surface of aortic endothelium was significantly elevated in hyperhomocysteinemic rats. There was a significant increase in the expression of MCP-1, vascular cell adhesion molecule-1 (VCAM-1), and E-selectin in the endothelium. Antibodies recognizing MCP-1, VCAM-1, or E-selectin could abolish the enhanced monocyte binding to the aortic endothelium of hyperhomocysteinemic rats. Endothelium-dependent aortic relaxation was impaired in hyperhomocysteinemic rats. Conclusions - These results suggest that in the absence of other known risk factors, hyperhomocysteinemia stimulates the expression of MCP-1, VCAM-1, and E-selectin in vivo, leading to increased monocyte adhesion to the aortic endothelium. Such an effect may contribute significantly to the development of atherosclerosis by facilitating monocyte/macrophage infiltration into the arterial wall.-
dc.languageeng-
dc.relation.ispartofArteriosclerosis, Thrombosis, and Vascular Biology-
dc.titleIncreased monocyte adhesion to aortic endothelium in rats with hyperhomocysteinemia: Role of chemokine and adhesion molecules-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1161/01.ATV.0000035404.18281.37-
dc.identifier.pmid12426204-
dc.identifier.scopuseid_2-s2.0-0036847780-
dc.identifier.volume22-
dc.identifier.issue11-
dc.identifier.spage1777-
dc.identifier.epage1783-
dc.identifier.isiWOS:000179258000009-

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