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Article: Is BRAFV600E mutation a marker for central nodal metastasis in small papillary thyroid carcinoma?

TitleIs BRAFV600E mutation a marker for central nodal metastasis in small papillary thyroid carcinoma?
Authors
Issue Date2014
PublisherBioScientifica Ltd. The Journal's web site is located at http://erc.endocrinology-journals.org
Citation
Endocrine-Related Cancer, 2014, v. 21 n. 2, p. 285-295 How to Cite?
AbstractUtilizing BRAFV600E mutation as a marker may reduce unnecessary prophylactic central neck dissection (pCND) in clinically nodal negative (cN0) neck for small (≤2 cm) classical papillary thyroid carcinoma (PTC). We aimed to assess whether BRAF is a significant independent predictor of occult central nodal metastasis (CNM) and its contribution to the overall prediction after adjusting for other significant preoperative clinical factors in small PTC. Primary tumor tissue (paraffin-embedded) from 845 patients with small classical cN0 PTC who underwent pCND was tested for BRAF mutation. Clinicopathologic factors were compared between those with and without BRAF. BRAF was evaluated to see if it was an independent factor for CNM. Prediction scores were generated using logistic regression models and their predictability was measured by the area under the ROC curve (AUC). The prevalence of BRAF was 628/845 (74.3%) while the rate of CNM was 285/845 (33.7%). Male sex (odds ratio (OR): 2.68, 95% CI: 1.71–4.20), large tumor size (OR: 2.68, 95% CI: 1.80–4.00), multifocality (OR: 1.49, 95% CI: 1.07–2.09), lymphovascular permeation (OR: 10.40, 95% CI: 5.18–20.88), and BRAF (OR: 1.65, 95% CI: 1.10–2.46) were significant independent predictors of CNM, while coexisting Hashimoto's thyroiditis (OR: 0.56, 95% CI: 0.40–0.80) was an independent protective factor. The AUC for prediction score based on tumor size and male sex was similar to that of prediction score based on tumor size, male sex, and BRAF status (0.68 vs 0.69, P=0.60). Although BRAF was an independent predictor of CNM, knowing its status did not substantially improve the overall prediction. A simpler prediction score based on male sex and tumor size might be sufficient.
Persistent Identifierhttp://hdl.handle.net/10722/193917
ISSN
2015 Impact Factor: 4.472
2015 SCImago Journal Rankings: 2.140

 

DC FieldValueLanguage
dc.contributor.authorLang, BHH-
dc.contributor.authorChai, YJ-
dc.contributor.authorCowling, BJ-
dc.contributor.authorMin, HS-
dc.contributor.authorLee, KE-
dc.contributor.authorYoun, YK-
dc.date.accessioned2014-01-28T06:33:26Z-
dc.date.available2014-01-28T06:33:26Z-
dc.date.issued2014-
dc.identifier.citationEndocrine-Related Cancer, 2014, v. 21 n. 2, p. 285-295-
dc.identifier.issn1351-0088-
dc.identifier.urihttp://hdl.handle.net/10722/193917-
dc.description.abstractUtilizing BRAFV600E mutation as a marker may reduce unnecessary prophylactic central neck dissection (pCND) in clinically nodal negative (cN0) neck for small (≤2 cm) classical papillary thyroid carcinoma (PTC). We aimed to assess whether BRAF is a significant independent predictor of occult central nodal metastasis (CNM) and its contribution to the overall prediction after adjusting for other significant preoperative clinical factors in small PTC. Primary tumor tissue (paraffin-embedded) from 845 patients with small classical cN0 PTC who underwent pCND was tested for BRAF mutation. Clinicopathologic factors were compared between those with and without BRAF. BRAF was evaluated to see if it was an independent factor for CNM. Prediction scores were generated using logistic regression models and their predictability was measured by the area under the ROC curve (AUC). The prevalence of BRAF was 628/845 (74.3%) while the rate of CNM was 285/845 (33.7%). Male sex (odds ratio (OR): 2.68, 95% CI: 1.71–4.20), large tumor size (OR: 2.68, 95% CI: 1.80–4.00), multifocality (OR: 1.49, 95% CI: 1.07–2.09), lymphovascular permeation (OR: 10.40, 95% CI: 5.18–20.88), and BRAF (OR: 1.65, 95% CI: 1.10–2.46) were significant independent predictors of CNM, while coexisting Hashimoto's thyroiditis (OR: 0.56, 95% CI: 0.40–0.80) was an independent protective factor. The AUC for prediction score based on tumor size and male sex was similar to that of prediction score based on tumor size, male sex, and BRAF status (0.68 vs 0.69, P=0.60). Although BRAF was an independent predictor of CNM, knowing its status did not substantially improve the overall prediction. A simpler prediction score based on male sex and tumor size might be sufficient.-
dc.languageeng-
dc.publisherBioScientifica Ltd. The Journal's web site is located at http://erc.endocrinology-journals.org-
dc.relation.ispartofEndocrine-Related Cancer-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleIs BRAFV600E mutation a marker for central nodal metastasis in small papillary thyroid carcinoma?-
dc.typeArticle-
dc.identifier.emailLang, BHH: Blang@hku.hk-
dc.identifier.emailCowling, BJ: bcowling@hku.hk-
dc.identifier.authorityLang, BHH=rp01828-
dc.identifier.authorityCowling, BJ=rp01326-
dc.description.naturepostprint-
dc.identifier.doi10.1530/ERC-13-0291-
dc.identifier.pmid24402044-
dc.identifier.hkuros227454-
dc.identifier.volume21-
dc.identifier.issue2-
dc.identifier.spage285-
dc.identifier.epage295-
dc.publisher.placeUnited Kingdom-

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