File Download
Supplementary
-
Citations:
- Appears in Collections:
postgraduate thesis: Vitamin D deficiency in patients with type 2 diabetes in a Shanghai hospital : the impact on glycemic control
Title | Vitamin D deficiency in patients with type 2 diabetes in a Shanghai hospital : the impact on glycemic control |
---|---|
Authors | |
Issue Date | 2013 |
Publisher | The University of Hong Kong (Pokfulam, Hong Kong) |
Citation | Zhuang, X. [庄小鸣]. (2013). Vitamin D deficiency in patients with type 2 diabetes in a Shanghai hospital : the impact on glycemic control. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5099026 |
Abstract | Objective:Low vitamin D has been implicated in the development of type 2 diabetes. However, whether vitamin D continues to have a clinically significant effect in existing diabetes is unclear. The objective of this study was to examine the association of serum vitamin D with glycemic control in established type 2 diabetes.
Methods: This was a retrospective analysis of medical records. Characteristics of 487 patients with type 2 diabetes were stratified by vitamin D status and serum glycosylated hemoglobin (HbA1c). Vitamin D deficiency among the subjects was studied. The relationship between vitamin D and glycemic control was explored by multiple linear regression, multivariate analysis of variance (MANOVA) and chi-square test. Patients were stratified into overweight and non-overweight group based on body mass index (BMI), and the association of serum vitamin D concentration with glycemic control was evaluated in each group. Insulin resistance and C-peptide as mediators between vitamin D and HbA1c was tested. The impact of vitamin D on cholesterol metabolism was also assessed.
Results: (1) Vitamin D deficiency was highly prevalent, accounting for 88.3% of the study sample. (2) Serum vitamin D levels were significantly inversely associated with serum HbA1c. This correlation was stronger in overweight group than in non-overweight group. There was no significant relationship between serum vitamin D levels and fasting plasma glucose (FPG). HbA1c was significantly lower in vitamin D insufficiency group than in vitamin D severe deficiency group. (3) Insulin resistance partially mediated the association between vitamin D and HbA1c. (4) No significant association of Vitamin D with low density lipoprotein (LDL) or high density lipoprotein (HDL) was found in this study.
Conclusions: There was an inverse association between serum vitamin D levels and HbA1c. The inverse correlation of serum vitamin D level and HbA1c was stronger in overweight group than in non-overweight group, which indicates patients with obesity might benefit more from vitamin D supplementation. |
Degree | Master of Public Health |
Subject | Vitamin D deficiency Non-insulin-dependent diabetes |
Dept/Program | Public Health |
Persistent Identifier | http://hdl.handle.net/10722/193833 |
HKU Library Item ID | b5099026 |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Zhuang, Xiaoming | - |
dc.contributor.author | 庄小鸣 | - |
dc.date.accessioned | 2014-01-27T23:10:50Z | - |
dc.date.available | 2014-01-27T23:10:50Z | - |
dc.date.issued | 2013 | - |
dc.identifier.citation | Zhuang, X. [庄小鸣]. (2013). Vitamin D deficiency in patients with type 2 diabetes in a Shanghai hospital : the impact on glycemic control. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5099026 | - |
dc.identifier.uri | http://hdl.handle.net/10722/193833 | - |
dc.description.abstract | Objective:Low vitamin D has been implicated in the development of type 2 diabetes. However, whether vitamin D continues to have a clinically significant effect in existing diabetes is unclear. The objective of this study was to examine the association of serum vitamin D with glycemic control in established type 2 diabetes. Methods: This was a retrospective analysis of medical records. Characteristics of 487 patients with type 2 diabetes were stratified by vitamin D status and serum glycosylated hemoglobin (HbA1c). Vitamin D deficiency among the subjects was studied. The relationship between vitamin D and glycemic control was explored by multiple linear regression, multivariate analysis of variance (MANOVA) and chi-square test. Patients were stratified into overweight and non-overweight group based on body mass index (BMI), and the association of serum vitamin D concentration with glycemic control was evaluated in each group. Insulin resistance and C-peptide as mediators between vitamin D and HbA1c was tested. The impact of vitamin D on cholesterol metabolism was also assessed. Results: (1) Vitamin D deficiency was highly prevalent, accounting for 88.3% of the study sample. (2) Serum vitamin D levels were significantly inversely associated with serum HbA1c. This correlation was stronger in overweight group than in non-overweight group. There was no significant relationship between serum vitamin D levels and fasting plasma glucose (FPG). HbA1c was significantly lower in vitamin D insufficiency group than in vitamin D severe deficiency group. (3) Insulin resistance partially mediated the association between vitamin D and HbA1c. (4) No significant association of Vitamin D with low density lipoprotein (LDL) or high density lipoprotein (HDL) was found in this study. Conclusions: There was an inverse association between serum vitamin D levels and HbA1c. The inverse correlation of serum vitamin D level and HbA1c was stronger in overweight group than in non-overweight group, which indicates patients with obesity might benefit more from vitamin D supplementation. | - |
dc.language | eng | - |
dc.publisher | The University of Hong Kong (Pokfulam, Hong Kong) | - |
dc.relation.ispartof | HKU Theses Online (HKUTO) | - |
dc.rights | The author retains all proprietary rights, (such as patent rights) and the right to use in future works. | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject.lcsh | Vitamin D deficiency | - |
dc.subject.lcsh | Non-insulin-dependent diabetes | - |
dc.title | Vitamin D deficiency in patients with type 2 diabetes in a Shanghai hospital : the impact on glycemic control | - |
dc.type | PG_Thesis | - |
dc.identifier.hkul | b5099026 | - |
dc.description.thesisname | Master of Public Health | - |
dc.description.thesislevel | Master | - |
dc.description.thesisdiscipline | Public Health | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.5353/th_b5099026 | - |
dc.date.hkucongregation | 2013 | - |
dc.identifier.mmsid | 991035887569703414 | - |