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Conference Paper: Long term treatment outcome of conventional high grade osteosarcoma in Hong Kong children and adolescents: from the Hong Kong Paediatric Haematology and Oncology Study Group

TitleLong term treatment outcome of conventional high grade osteosarcoma in Hong Kong children and adolescents: from the Hong Kong Paediatric Haematology and Oncology Study Group
Authors
KeywordsMedical sciences
Oncology medical sciences
Pediatrics
Issue Date2013
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1545-5017/
Citation
The 45th Congress of the International Society of Paediatric Oncology (SIOP 2013), Hong Kong, China, 25-28 September 2013. In Pediatric Blood & Cancer, 2013, v. 60 S3, p. 87, abstract no. P-0141 How to Cite?
AbstractPURPOSE/OBJECTIVE: To assess long-term outcome in Hong Kong osteosarcoma children and adolescents treated with a standard region-wide protocol. MATERIALS AND METHODS: Children and adolescents diagnosed with conventional high-grade osteosarcoma between Nov 1993 and Dec 2010 were included. They were treated according to HKPHOSG Osteosarcoma 1993 protocol. They received 8 weeks of neo-adjuvant chemotherapy with cisplatin, adriamycin and methotrexate, tumour resection at week 10, and post-operative chemotherapy, totally for 27 weeks for good responders with ≥90% tumour necrosis, or for 40 weeks with methotrexate replaced by ifosfamide and etoposide from week 16 for poor responders. RESULTS: Total of 117 patients (65 males, 52 females; median age at diagnosis 12.3, range 0.6*20, years) were treated. Ninety-seven patients (83%) had localized disease; 20 had metastases (pulmonary, n = 15; skip bone, n = 2; multifocal bone, n = 1; bone and pulmonary, n =2). Thirteen patients (11%) had disease progression on treatment. Twenty-eight (24%) patients developed relapses at median time of 1.84 year from diagnosis (range 0.48*12.74). With further definitive surgery, 8 relapsed patients were salvaged and alive without diseases. All patients with relapses not amendable to surgery died. Thirty-seven patients died (progression on treatment, n = 13; after relapses, n = 21; cardiomyopathy, n = 1; early post-operative complication, n = 1; unrelated cause, n = 1). 5-year OS and EFS for patients with localized and metastatic diseases were 77.2% and 68.2%; and 26.9% and 28.1%, respectively. Late complications included renal and tubular function impairment (n = 14), senorineural hearing deficit (n = 10), and second malignancies (n = 3: glioblastoma multiforme, papillary carcinoma of thyroid, therapy related acute myeloid leukaemia). Two patients gave birth to babies 5 and 10 years after initial diagnosis. CONCLUSIONS: Children and adolescents with localized osteosarcoma who receive multiagent chemotherapy under our protocol have a favourable outcome. Prolonged survival and cure is possible for surgically amendable relapses. However, new strategies need to be explored for patients with metastatic diseases.
DescriptionThis journal suppl. entitled: Supplement: SIOP Abstratcs: 45th Congress of the International Society of Paediatric Oncology (SIOP) ... 2013
Poster Session - Bone tumours: abstract no. P-0141
Persistent Identifierhttp://hdl.handle.net/10722/193642
ISSN
2015 Impact Factor: 2.634
2015 SCImago Journal Rankings: 1.505

 

DC FieldValueLanguage
dc.contributor.authorLee, Ven_US
dc.contributor.authorLuk, CWen_US
dc.contributor.authorCheuk, DKLen_US
dc.contributor.authorLi, CHen_US
dc.contributor.authorLing, SCen_US
dc.contributor.authorLeung, AWKen_US
dc.contributor.authorYuen, HLen_US
dc.contributor.authorChiang, AKSen_US
dc.contributor.authorShing, MMKen_US
dc.date.accessioned2014-01-20T05:12:16Z-
dc.date.available2014-01-20T05:12:16Z-
dc.date.issued2013en_US
dc.identifier.citationThe 45th Congress of the International Society of Paediatric Oncology (SIOP 2013), Hong Kong, China, 25-28 September 2013. In Pediatric Blood & Cancer, 2013, v. 60 S3, p. 87, abstract no. P-0141en_US
dc.identifier.issn1545-5009-
dc.identifier.urihttp://hdl.handle.net/10722/193642-
dc.descriptionThis journal suppl. entitled: Supplement: SIOP Abstratcs: 45th Congress of the International Society of Paediatric Oncology (SIOP) ... 2013-
dc.descriptionPoster Session - Bone tumours: abstract no. P-0141-
dc.description.abstractPURPOSE/OBJECTIVE: To assess long-term outcome in Hong Kong osteosarcoma children and adolescents treated with a standard region-wide protocol. MATERIALS AND METHODS: Children and adolescents diagnosed with conventional high-grade osteosarcoma between Nov 1993 and Dec 2010 were included. They were treated according to HKPHOSG Osteosarcoma 1993 protocol. They received 8 weeks of neo-adjuvant chemotherapy with cisplatin, adriamycin and methotrexate, tumour resection at week 10, and post-operative chemotherapy, totally for 27 weeks for good responders with ≥90% tumour necrosis, or for 40 weeks with methotrexate replaced by ifosfamide and etoposide from week 16 for poor responders. RESULTS: Total of 117 patients (65 males, 52 females; median age at diagnosis 12.3, range 0.6*20, years) were treated. Ninety-seven patients (83%) had localized disease; 20 had metastases (pulmonary, n = 15; skip bone, n = 2; multifocal bone, n = 1; bone and pulmonary, n =2). Thirteen patients (11%) had disease progression on treatment. Twenty-eight (24%) patients developed relapses at median time of 1.84 year from diagnosis (range 0.48*12.74). With further definitive surgery, 8 relapsed patients were salvaged and alive without diseases. All patients with relapses not amendable to surgery died. Thirty-seven patients died (progression on treatment, n = 13; after relapses, n = 21; cardiomyopathy, n = 1; early post-operative complication, n = 1; unrelated cause, n = 1). 5-year OS and EFS for patients with localized and metastatic diseases were 77.2% and 68.2%; and 26.9% and 28.1%, respectively. Late complications included renal and tubular function impairment (n = 14), senorineural hearing deficit (n = 10), and second malignancies (n = 3: glioblastoma multiforme, papillary carcinoma of thyroid, therapy related acute myeloid leukaemia). Two patients gave birth to babies 5 and 10 years after initial diagnosis. CONCLUSIONS: Children and adolescents with localized osteosarcoma who receive multiagent chemotherapy under our protocol have a favourable outcome. Prolonged survival and cure is possible for surgically amendable relapses. However, new strategies need to be explored for patients with metastatic diseases.-
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1545-5017/-
dc.relation.ispartofPediatric Blood & Canceren_US
dc.rightsPediatric Blood & Cancer. Copyright © John Wiley & Sons, Inc.-
dc.subjectMedical sciences-
dc.subjectOncology medical sciences-
dc.subjectPediatrics-
dc.titleLong term treatment outcome of conventional high grade osteosarcoma in Hong Kong children and adolescents: from the Hong Kong Paediatric Haematology and Oncology Study Groupen_US
dc.typeConference_Paperen_US
dc.identifier.emailCheuk, DKL: klcheuk@hkucc.hku.hken_US
dc.identifier.emailChiang, AKS: chiangak@hku.hken_US
dc.identifier.authorityChiang, AKS=rp00403en_US
dc.identifier.doi10.1002/pbc.24719-
dc.identifier.hkuros227224en_US
dc.identifier.volume60-
dc.identifier.issueS3-
dc.identifier.spage87-
dc.identifier.epage87-
dc.publisher.placeUnited States-

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