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Conference Paper: Cystic-like liver tumours in children: two diseases with similar appearance but required different treatment approach
Title | Cystic-like liver tumours in children: two diseases with similar appearance but required different treatment approach |
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Authors | |
Keywords | Medical sciences Oncology medical sciences Pediatrics |
Issue Date | 2013 |
Publisher | John Wiley & Sons, Inc. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1545-5017/ |
Citation | The 45th Congress of the International Society of Paediatric Oncology (SIOP 2013), Hong Kong, China, 25-28 September 2013. In Pediatric Blood & Cancer, 2013, v. 60 n. S3, p. 107-108, abstract no. P-0229 How to Cite? |
Abstract | PURPOSE/OBJECTIVE: Liver tumour only accounts for 0.5-2% of all tumours in children. Cystic-like hepatic tumours such as undifferentiated embryonal sarcoma (UES) and mesenchymal hamartoma (MH) are even rarer. Due to the differences in prognosis and treatment, timely and accurate diagnosis is essential. However, their closely resembling clinical characteristics make the initial diagnosis difficult. We reviewed our experience and tried to identify any unique clinical pattern. MATERIALS AND METHODS: This is a retrospective review of patients’ charts and database over a 15-yrs period. Clinical and imaging characteristics of indexed patients were analyzed. RESULTS: 2 cases each of UES & MH were identified and all were confirmed histopathologically. Their age of diagnoses were 10mos, 10yrs, 13yrs & 15yrs and 3 were girl. Both MH patients presented with abdominal distension without other symptoms. In contrary, one UES patient had abdominal distension and pain associated with anorexia and weight loss. There were no remarkable laboratory results except one MH patient had mild elevated liver parenchymal enzymes and alpha-fetoprotein. Both ultrasonography & CT-scan showed multiple cystic + / - solid lesions in all patients with MH and UES. The tumours of two cases with MH were gross totally excised and the ’cysts’ were actually myxoid tissue. Trisegmentectomy of liver was done due to rapidly mounting abdominal distension and pain in one UES patient. The other UES patient underwent hemi-hepatectomy. Both UES patients received chemotherapy (IRS-IV protocol). All patients achieved long term remission. Interestingly, both UES patients were found to have multiple hypo-enhancing liver lesions suggestive of metastasis in 6 to 12-months after completing chemotherapy but turned out to be focal nodular hyperplasia by biopsy. CONCLUSIONS::MH & UES had similar imaging appearance and possible pathological overlap; the presenting patterns may be more striking in some UES patients. However, surgical biopsy and excision remained mandatory to confirm the diagnosis and guide the subsequent treatment. |
Description | This journal suppl. entitled: Supplement: SIOP Abstratcs: 45th Congress of the International Society of Paediatric Oncology (SIOP) ... 2013 Poster Session - Liver tumours: abstract no. P-0229 |
Persistent Identifier | http://hdl.handle.net/10722/193641 |
ISSN | 2023 Impact Factor: 2.4 2023 SCImago Journal Rankings: 0.992 |
DC Field | Value | Language |
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dc.contributor.author | Yu, JL | en_US |
dc.contributor.author | Khong, PL | en_US |
dc.contributor.author | Chiang, AKS | en_US |
dc.contributor.author | Cheuk, DKL | en_US |
dc.contributor.author | Ha, SY | en_US |
dc.contributor.author | Chan, GC | en_US |
dc.date.accessioned | 2014-01-20T05:12:16Z | - |
dc.date.available | 2014-01-20T05:12:16Z | - |
dc.date.issued | 2013 | en_US |
dc.identifier.citation | The 45th Congress of the International Society of Paediatric Oncology (SIOP 2013), Hong Kong, China, 25-28 September 2013. In Pediatric Blood & Cancer, 2013, v. 60 n. S3, p. 107-108, abstract no. P-0229 | en_US |
dc.identifier.issn | 1545-5009 | - |
dc.identifier.uri | http://hdl.handle.net/10722/193641 | - |
dc.description | This journal suppl. entitled: Supplement: SIOP Abstratcs: 45th Congress of the International Society of Paediatric Oncology (SIOP) ... 2013 | - |
dc.description | Poster Session - Liver tumours: abstract no. P-0229 | - |
dc.description.abstract | PURPOSE/OBJECTIVE: Liver tumour only accounts for 0.5-2% of all tumours in children. Cystic-like hepatic tumours such as undifferentiated embryonal sarcoma (UES) and mesenchymal hamartoma (MH) are even rarer. Due to the differences in prognosis and treatment, timely and accurate diagnosis is essential. However, their closely resembling clinical characteristics make the initial diagnosis difficult. We reviewed our experience and tried to identify any unique clinical pattern. MATERIALS AND METHODS: This is a retrospective review of patients’ charts and database over a 15-yrs period. Clinical and imaging characteristics of indexed patients were analyzed. RESULTS: 2 cases each of UES & MH were identified and all were confirmed histopathologically. Their age of diagnoses were 10mos, 10yrs, 13yrs & 15yrs and 3 were girl. Both MH patients presented with abdominal distension without other symptoms. In contrary, one UES patient had abdominal distension and pain associated with anorexia and weight loss. There were no remarkable laboratory results except one MH patient had mild elevated liver parenchymal enzymes and alpha-fetoprotein. Both ultrasonography & CT-scan showed multiple cystic + / - solid lesions in all patients with MH and UES. The tumours of two cases with MH were gross totally excised and the ’cysts’ were actually myxoid tissue. Trisegmentectomy of liver was done due to rapidly mounting abdominal distension and pain in one UES patient. The other UES patient underwent hemi-hepatectomy. Both UES patients received chemotherapy (IRS-IV protocol). All patients achieved long term remission. Interestingly, both UES patients were found to have multiple hypo-enhancing liver lesions suggestive of metastasis in 6 to 12-months after completing chemotherapy but turned out to be focal nodular hyperplasia by biopsy. CONCLUSIONS::MH & UES had similar imaging appearance and possible pathological overlap; the presenting patterns may be more striking in some UES patients. However, surgical biopsy and excision remained mandatory to confirm the diagnosis and guide the subsequent treatment. | - |
dc.language | eng | en_US |
dc.publisher | John Wiley & Sons, Inc. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1545-5017/ | - |
dc.relation.ispartof | Pediatric Blood & Cancer | en_US |
dc.rights | Pediatric Blood & Cancer. Copyright © John Wiley & Sons, Inc. | - |
dc.subject | Medical sciences | - |
dc.subject | Oncology medical sciences | - |
dc.subject | Pediatrics | - |
dc.title | Cystic-like liver tumours in children: two diseases with similar appearance but required different treatment approach | en_US |
dc.type | Conference_Paper | en_US |
dc.identifier.email | Khong, PL: plkhong@hku.hk | en_US |
dc.identifier.email | Chiang, AKS: chiangak@hku.hk | en_US |
dc.identifier.email | Cheuk, DKL: klcheuk@hkucc.hku.hk | en_US |
dc.identifier.email | Ha, SY: syha@hku.hk | en_US |
dc.identifier.email | Chan, GC: gcfchan@hku.hk | - |
dc.identifier.authority | Khong, PL=rp00467 | en_US |
dc.identifier.authority | Chiang, AKS=rp00403 | en_US |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1002/pbc.24719 | - |
dc.identifier.hkuros | 227223 | en_US |
dc.identifier.volume | 60 | - |
dc.identifier.issue | suppl. 3 | - |
dc.identifier.spage | 107, abstract no. P-0229 | - |
dc.identifier.epage | 108 | - |
dc.publisher.place | United States | - |
dc.identifier.issnl | 1545-5009 | - |