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Conference Paper: Cystic-like liver tumours in children: two diseases with similar appearance but required different treatment approach

TitleCystic-like liver tumours in children: two diseases with similar appearance but required different treatment approach
Authors
KeywordsMedical sciences
Oncology medical sciences
Pediatrics
Issue Date2013
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1545-5017/
Citation
The 45th Congress of the International Society of Paediatric Oncology (SIOP 2013), Hong Kong, China, 25-28 September 2013. In Pediatric Blood & Cancer, 2013, v. 60 S3, p. 107-108, abstract no. P-0229 How to Cite?
AbstractPURPOSE/OBJECTIVE: Liver tumour only accounts for 0.5-2% of all tumours in children. Cystic-like hepatic tumours such as undifferentiated embryonal sarcoma (UES) and mesenchymal hamartoma (MH) are even rarer. Due to the differences in prognosis and treatment, timely and accurate diagnosis is essential. However, their closely resembling clinical characteristics make the initial diagnosis difficult. We reviewed our experience and tried to identify any unique clinical pattern. MATERIALS AND METHODS: This is a retrospective review of patients’ charts and database over a 15-yrs period. Clinical and imaging characteristics of indexed patients were analyzed. RESULTS: 2 cases each of UES & MH were identified and all were confirmed histopathologically. Their age of diagnoses were 10mos, 10yrs, 13yrs & 15yrs and 3 were girl. Both MH patients presented with abdominal distension without other symptoms. In contrary, one UES patient had abdominal distension and pain associated with anorexia and weight loss. There were no remarkable laboratory results except one MH patient had mild elevated liver parenchymal enzymes and alpha-fetoprotein. Both ultrasonography & CT-scan showed multiple cystic + / - solid lesions in all patients with MH and UES. The tumours of two cases with MH were gross totally excised and the ’cysts’ were actually myxoid tissue. Trisegmentectomy of liver was done due to rapidly mounting abdominal distension and pain in one UES patient. The other UES patient underwent hemi-hepatectomy. Both UES patients received chemotherapy (IRS-IV protocol). All patients achieved long term remission. Interestingly, both UES patients were found to have multiple hypo-enhancing liver lesions suggestive of metastasis in 6 to 12-months after completing chemotherapy but turned out to be focal nodular hyperplasia by biopsy. CONCLUSIONS::MH & UES had similar imaging appearance and possible pathological overlap; the presenting patterns may be more striking in some UES patients. However, surgical biopsy and excision remained mandatory to confirm the diagnosis and guide the subsequent treatment.
DescriptionThis journal suppl. entitled: Supplement: SIOP Abstratcs: 45th Congress of the International Society of Paediatric Oncology (SIOP) ... 2013
Poster Session - Liver tumours: abstract no. P-0229
Persistent Identifierhttp://hdl.handle.net/10722/193641
ISSN
2015 Impact Factor: 2.634
2015 SCImago Journal Rankings: 1.505

 

DC FieldValueLanguage
dc.contributor.authorYu, JLen_US
dc.contributor.authorKhong, PLen_US
dc.contributor.authorChiang, AKSen_US
dc.contributor.authorCheuk, DKLen_US
dc.contributor.authorHa, SYen_US
dc.contributor.authorChan, GCen_US
dc.date.accessioned2014-01-20T05:12:16Z-
dc.date.available2014-01-20T05:12:16Z-
dc.date.issued2013en_US
dc.identifier.citationThe 45th Congress of the International Society of Paediatric Oncology (SIOP 2013), Hong Kong, China, 25-28 September 2013. In Pediatric Blood & Cancer, 2013, v. 60 S3, p. 107-108, abstract no. P-0229en_US
dc.identifier.issn1545-5009-
dc.identifier.urihttp://hdl.handle.net/10722/193641-
dc.descriptionThis journal suppl. entitled: Supplement: SIOP Abstratcs: 45th Congress of the International Society of Paediatric Oncology (SIOP) ... 2013-
dc.descriptionPoster Session - Liver tumours: abstract no. P-0229-
dc.description.abstractPURPOSE/OBJECTIVE: Liver tumour only accounts for 0.5-2% of all tumours in children. Cystic-like hepatic tumours such as undifferentiated embryonal sarcoma (UES) and mesenchymal hamartoma (MH) are even rarer. Due to the differences in prognosis and treatment, timely and accurate diagnosis is essential. However, their closely resembling clinical characteristics make the initial diagnosis difficult. We reviewed our experience and tried to identify any unique clinical pattern. MATERIALS AND METHODS: This is a retrospective review of patients’ charts and database over a 15-yrs period. Clinical and imaging characteristics of indexed patients were analyzed. RESULTS: 2 cases each of UES & MH were identified and all were confirmed histopathologically. Their age of diagnoses were 10mos, 10yrs, 13yrs & 15yrs and 3 were girl. Both MH patients presented with abdominal distension without other symptoms. In contrary, one UES patient had abdominal distension and pain associated with anorexia and weight loss. There were no remarkable laboratory results except one MH patient had mild elevated liver parenchymal enzymes and alpha-fetoprotein. Both ultrasonography & CT-scan showed multiple cystic + / - solid lesions in all patients with MH and UES. The tumours of two cases with MH were gross totally excised and the ’cysts’ were actually myxoid tissue. Trisegmentectomy of liver was done due to rapidly mounting abdominal distension and pain in one UES patient. The other UES patient underwent hemi-hepatectomy. Both UES patients received chemotherapy (IRS-IV protocol). All patients achieved long term remission. Interestingly, both UES patients were found to have multiple hypo-enhancing liver lesions suggestive of metastasis in 6 to 12-months after completing chemotherapy but turned out to be focal nodular hyperplasia by biopsy. CONCLUSIONS::MH & UES had similar imaging appearance and possible pathological overlap; the presenting patterns may be more striking in some UES patients. However, surgical biopsy and excision remained mandatory to confirm the diagnosis and guide the subsequent treatment.-
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1545-5017/-
dc.relation.ispartofPediatric Blood & Canceren_US
dc.rightsPediatric Blood & Cancer. Copyright © John Wiley & Sons, Inc.-
dc.subjectMedical sciences-
dc.subjectOncology medical sciences-
dc.subjectPediatrics-
dc.titleCystic-like liver tumours in children: two diseases with similar appearance but required different treatment approachen_US
dc.typeConference_Paperen_US
dc.identifier.emailKhong, PL: plkhong@hku.hken_US
dc.identifier.emailChiang, AKS: chiangak@hku.hken_US
dc.identifier.emailCheuk, DKL: klcheuk@hkucc.hku.hken_US
dc.identifier.emailHa, SY: syha@hku.hken_US
dc.identifier.emailChan, GC: gcfchan@hku.hk-
dc.identifier.authorityKhong, PL=rp00467en_US
dc.identifier.authorityChiang, AKS=rp00403en_US
dc.identifier.doi10.1002/pbc.24719-
dc.identifier.hkuros227223en_US
dc.identifier.volume60-
dc.identifier.issueS3-
dc.identifier.spage107-
dc.identifier.epage108-
dc.publisher.placeUnited States-

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