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Conference Paper: Improving outcomes of hematopoietic stem cell transplant for pediatric acute lymphoblastic leukemia in Hong Kong

TitleImproving outcomes of hematopoietic stem cell transplant for pediatric acute lymphoblastic leukemia in Hong Kong
Authors
KeywordsMedical sciences
Oncology medical sciences
Pediatrics
Issue Date2013
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1545-5017/
Citation
The 45th Congress of the International Society of Paediatric Oncology (SIOP 2013), Hong Kong, China, 25-28 September 2013. In Pediatric Blood & Cancer, 2013, v. 60 S3, p. 70, abstract no. P-0066 How to Cite?
AbstractPURPOSE/OBJECTIVE: Our unit is one of the two pediatric hematopoietic stem cell transplant (HSCT) centres in Hong Kong. We started to perform HSCT for children with acute lymphoblastic leukemia (ALL) in 1993. We aimed to review their outcomes in the past 20 years. MATERIALS AND METHODS: This is a retrospective review of the patient and transplant characteristics and transplant outcomes of children with ALL who underwent HSCT in our unit in 1993-2012. RESULTS: We have performed allogeneic HSCT for 35 children (26 males and 9 females) with ALL. The median age at HSCT was 7.6 years (range, 0.8 to 17.0 years). Twelve children were transplanted in first complete remission, 17 in second remission, 4 in third remission, and 2 with non-remission. Donors were matched sibling (n ? 14), 1-antigen mismatched parent (n ? 3), matched unrelated donor (n ? 8), or unrelated cord blood (n ? 10). Conditioning employed total body irradiation plus etoposide and/or cyclophosphamide in children above 3 years old, and busulfan, cyclophosphamide and melphalan in children below 3 years. Five year overall survival (OS) and relapse-free survival (RFS) were better after year 2000 (OS:75.7% vs. 50.0%; RFS: 76.7% vs. 50.0%). The differences in OS and RFS in different eras were statistically significant after adjusting for age, gender, remission status, and type of donors (p ? 0.035 for OS and p ? 0.016 for RFS). Transplant-related mortalities were 33.3% before 2000 and 13.0% after 2000. CONCLUSIONS: Transplant outcomes for pediatric ALL steadily improved in Hong Kong in the past 20 years. This was likely attributable to improvement in supportive care with reduction in transplant-related mortality.
DescriptionPoster Session - Acute Lymphoblastic Leukaemia: no. P-0066
This journal suppl. entitled: Supplement: SIOP Abstratcs: 45th Congress of the International Society of Paediatric Oncology (SIOP) ... 2013
Persistent Identifierhttp://hdl.handle.net/10722/193638
ISSN
2015 Impact Factor: 2.634
2015 SCImago Journal Rankings: 1.505

 

DC FieldValueLanguage
dc.contributor.authorCheuk, DKLen_US
dc.contributor.authorChiang, Aen_US
dc.contributor.authorHa, SYen_US
dc.contributor.authorChan, Gen_US
dc.date.accessioned2014-01-20T05:12:15Z-
dc.date.available2014-01-20T05:12:15Z-
dc.date.issued2013en_US
dc.identifier.citationThe 45th Congress of the International Society of Paediatric Oncology (SIOP 2013), Hong Kong, China, 25-28 September 2013. In Pediatric Blood & Cancer, 2013, v. 60 S3, p. 70, abstract no. P-0066en_US
dc.identifier.issn1545-5009-
dc.identifier.urihttp://hdl.handle.net/10722/193638-
dc.descriptionPoster Session - Acute Lymphoblastic Leukaemia: no. P-0066-
dc.descriptionThis journal suppl. entitled: Supplement: SIOP Abstratcs: 45th Congress of the International Society of Paediatric Oncology (SIOP) ... 2013-
dc.description.abstractPURPOSE/OBJECTIVE: Our unit is one of the two pediatric hematopoietic stem cell transplant (HSCT) centres in Hong Kong. We started to perform HSCT for children with acute lymphoblastic leukemia (ALL) in 1993. We aimed to review their outcomes in the past 20 years. MATERIALS AND METHODS: This is a retrospective review of the patient and transplant characteristics and transplant outcomes of children with ALL who underwent HSCT in our unit in 1993-2012. RESULTS: We have performed allogeneic HSCT for 35 children (26 males and 9 females) with ALL. The median age at HSCT was 7.6 years (range, 0.8 to 17.0 years). Twelve children were transplanted in first complete remission, 17 in second remission, 4 in third remission, and 2 with non-remission. Donors were matched sibling (n ? 14), 1-antigen mismatched parent (n ? 3), matched unrelated donor (n ? 8), or unrelated cord blood (n ? 10). Conditioning employed total body irradiation plus etoposide and/or cyclophosphamide in children above 3 years old, and busulfan, cyclophosphamide and melphalan in children below 3 years. Five year overall survival (OS) and relapse-free survival (RFS) were better after year 2000 (OS:75.7% vs. 50.0%; RFS: 76.7% vs. 50.0%). The differences in OS and RFS in different eras were statistically significant after adjusting for age, gender, remission status, and type of donors (p ? 0.035 for OS and p ? 0.016 for RFS). Transplant-related mortalities were 33.3% before 2000 and 13.0% after 2000. CONCLUSIONS: Transplant outcomes for pediatric ALL steadily improved in Hong Kong in the past 20 years. This was likely attributable to improvement in supportive care with reduction in transplant-related mortality.-
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1545-5017/-
dc.relation.ispartofPediatric Blood & Canceren_US
dc.rightsPediatric Blood & Cancer. Copyright © John Wiley & Sons, Inc.-
dc.subjectMedical sciences-
dc.subjectOncology medical sciences-
dc.subjectPediatrics-
dc.titleImproving outcomes of hematopoietic stem cell transplant for pediatric acute lymphoblastic leukemia in Hong Kongen_US
dc.typeConference_Paperen_US
dc.identifier.emailCheuk, DKL: klcheuk@hkucc.hku.hken_US
dc.identifier.emailChiang, A: chiangak@hku.hken_US
dc.identifier.emailHa, SY: syha@hku.hken_US
dc.identifier.emailChan, G: gcfchan@hku.hken_US
dc.identifier.authorityChiang, A=rp00403en_US
dc.identifier.authorityChan, G=rp00431en_US
dc.identifier.doi10.1002/pbc.24719-
dc.identifier.hkuros227216en_US
dc.identifier.volume60-
dc.identifier.issueS3-
dc.identifier.spage70-
dc.identifier.epage70-
dc.publisher.placeUnited States-

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