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Conference Paper: Results of a uniform treatment protocol based on the Fab/Lmb96 study for B cell non-hodgkin lymphoma in children and adolescents of Hong Kong

TitleResults of a uniform treatment protocol based on the Fab/Lmb96 study for B cell non-hodgkin lymphoma in children and adolescents of Hong Kong
Authors
KeywordsMedical sciences
Oncology medical sciences
Pediatrics
Issue Date2013
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1545-5017/
Citation
The 45th Congress of the International Society of Paediatric Oncology (SIOP 2013), Hong Kong, China, 25-28 September 2013. In Pediatric Blood & Cancer, 2013, v. 60 S3, p. 79, abstarct P-0106 How to Cite?
AbstractPURPOSE/OBJECTIVE: Survival has steadily improved for mature childhood B cell non-Hodgkin lymphoma (NHL) using short intensive treatment regimens. We aim to review the results of a uniform territory-wide treatment protocol for B cell NHL established in Hong Kong since 1998. MATERIALS AND METHODS: The five hospitals of Hong Kong forming the Hong Kong Paediatric Haematology and Oncology Study Group (HKPHOSG) established a uniform treatment protocol based on the FAB/LMB96 study to treat children and adolescents with B cell NHL since 1998. The clinical data of all cases diagnosed between 1-Jan-1998 and 31-Dec-2011 were reviewed up to the date of 31-Dec-2012. RESULTS: During the study period, a total of 55 cases including 44 with Burkitt lymphoma (BL) and 11 with diffuse large B cell lymphoma (DLBCL) were diagnosed. Six cases of primary mediastinal large B cell lymphomas were excluded. Forty-two (76%) were males. The median age was 7.7 years (range, 2.6 to 17.8 years). The median follow up duration was 5.8 years (range, 0.11 to 16.1 years). The Murphy stages consisted of 13% stage 1 (n = 7), 25% stage 2 (n = 14), 31% stage 3 (n = 17) and 31% stage 4 (n = 17). Six cases (11%) had CNS involvement. Treatment groups were stratified as 11% group A (n = 6), 65% group B (n = 36) and 24% group C (n = 13; 7 CNS-; 6 CNS+). The 5-year event-free survival (EFS) and overall survival (S) were 80.9% and 84.8%, with those for BL 79.1% and 81.4% and for DLBCL 87.5% and 100%, respectively. The 5-year EFS and S for CNS- cases were 84.7% and 87.0% and those for CNS+ cases 50.0% and 66.7%, respectively (p ? 0.041 for CNS+ v CNS-). CONCLUSIONS: The treatment results for all stages of the CNS- B cell NHL are significantly better than those for the CNS+ cases. Future goal should aim at improving the survival of the CNS+ B cell NHL.
DescriptionThis journal suppl. entitled: Supplement: SIOP Abstratcs: 45th Congress of the International Society of Paediatric Oncology (SIOP) ... 2013
Poster Session - Lymphomas: abstract no. P-0106
Persistent Identifierhttp://hdl.handle.net/10722/193631
ISSN
2015 Impact Factor: 2.634
2015 SCImago Journal Rankings: 1.505

 

DC FieldValueLanguage
dc.contributor.authorChiang, AKen_US
dc.contributor.authorLee, Ven_US
dc.contributor.authorYuen, Hen_US
dc.contributor.authorLi, CBen_US
dc.contributor.authorLing, SCen_US
dc.contributor.authorCheuk, DKLen_US
dc.contributor.authorLee, ACWen_US
dc.date.accessioned2014-01-20T05:11:38Z-
dc.date.available2014-01-20T05:11:38Z-
dc.date.issued2013en_US
dc.identifier.citationThe 45th Congress of the International Society of Paediatric Oncology (SIOP 2013), Hong Kong, China, 25-28 September 2013. In Pediatric Blood & Cancer, 2013, v. 60 S3, p. 79, abstarct P-0106en_US
dc.identifier.issn1545-5009-
dc.identifier.urihttp://hdl.handle.net/10722/193631-
dc.descriptionThis journal suppl. entitled: Supplement: SIOP Abstratcs: 45th Congress of the International Society of Paediatric Oncology (SIOP) ... 2013-
dc.descriptionPoster Session - Lymphomas: abstract no. P-0106-
dc.description.abstractPURPOSE/OBJECTIVE: Survival has steadily improved for mature childhood B cell non-Hodgkin lymphoma (NHL) using short intensive treatment regimens. We aim to review the results of a uniform territory-wide treatment protocol for B cell NHL established in Hong Kong since 1998. MATERIALS AND METHODS: The five hospitals of Hong Kong forming the Hong Kong Paediatric Haematology and Oncology Study Group (HKPHOSG) established a uniform treatment protocol based on the FAB/LMB96 study to treat children and adolescents with B cell NHL since 1998. The clinical data of all cases diagnosed between 1-Jan-1998 and 31-Dec-2011 were reviewed up to the date of 31-Dec-2012. RESULTS: During the study period, a total of 55 cases including 44 with Burkitt lymphoma (BL) and 11 with diffuse large B cell lymphoma (DLBCL) were diagnosed. Six cases of primary mediastinal large B cell lymphomas were excluded. Forty-two (76%) were males. The median age was 7.7 years (range, 2.6 to 17.8 years). The median follow up duration was 5.8 years (range, 0.11 to 16.1 years). The Murphy stages consisted of 13% stage 1 (n = 7), 25% stage 2 (n = 14), 31% stage 3 (n = 17) and 31% stage 4 (n = 17). Six cases (11%) had CNS involvement. Treatment groups were stratified as 11% group A (n = 6), 65% group B (n = 36) and 24% group C (n = 13; 7 CNS-; 6 CNS+). The 5-year event-free survival (EFS) and overall survival (S) were 80.9% and 84.8%, with those for BL 79.1% and 81.4% and for DLBCL 87.5% and 100%, respectively. The 5-year EFS and S for CNS- cases were 84.7% and 87.0% and those for CNS+ cases 50.0% and 66.7%, respectively (p ? 0.041 for CNS+ v CNS-). CONCLUSIONS: The treatment results for all stages of the CNS- B cell NHL are significantly better than those for the CNS+ cases. Future goal should aim at improving the survival of the CNS+ B cell NHL.-
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1545-5017/-
dc.relation.ispartofPediatric Blood & Canceren_US
dc.rightsPediatric Blood & Cancer. Copyright © John Wiley & Sons, Inc.-
dc.subjectMedical sciences-
dc.subjectOncology medical sciences-
dc.subjectPediatrics-
dc.titleResults of a uniform treatment protocol based on the Fab/Lmb96 study for B cell non-hodgkin lymphoma in children and adolescents of Hong Kongen_US
dc.typeConference_Paperen_US
dc.identifier.emailChiang, AK: chiangak@hku.hken_US
dc.identifier.emailLi, CB: jamesli@hku.hken_US
dc.identifier.emailCheuk, DKL: klcheuk@hkucc.hku.hken_US
dc.identifier.authorityChiang, AK=rp00403en_US
dc.identifier.doi10.1002/pbc.24719-
dc.identifier.hkuros227222en_US
dc.identifier.volume60-
dc.identifier.issueS3-
dc.identifier.spage79-
dc.identifier.epage79-
dc.publisher.placeUnited States-

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