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postgraduate thesis: Kif5b may play a role in impairing mouse memory : a behaviour and cellular study

TitleKif5b may play a role in impairing mouse memory : a behaviour and cellular study
Authors
Issue Date2013
PublisherThe University of Hong Kong (Pokfulam, Hong Kong)
Citation
Lin, Y. [林扬骏]. (2013). Kif5b may play a role in impairing mouse memory : a behaviour and cellular study. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5091448
AbstractAlzheimer's Disease is one of the most fearsome diseases worldwide. The study of Alzheimer's Disease (AD) is broad and many have focused on investigating the various proteins involved in neurons. A popular hypothesis of the cellular mechanism of AD is the accumulation of beta-Amyloid. Kinesin is a large group of motor proteins, which plays an extensive role in mitosis and intracellular cargo transport, including that of the Amyloid Protein Precursor. In the present study we have performed fear conditioning behaviour tests on Kif5b conditional knockout (CKO) mouse. Kif5b CKO mouse shows an impair contextual memory compared to the wild type, but does not display an impaired auditory memory. Heterozygous Kif5b knock out mouse shows no significant difference to the wild type. The study has also generated Kif5b fragments and used them to pull-down proteins in mouse brain lysate. The study has identified Clathrin and alpha-Adaptin as binding partners of Kif5b in mouse neuronal cells. The binding domain of Kif5b for these proteins is between amino acid residue 891-935. Finally this study has made a number of recommendations for further study.
DegreeMaster of Medical Sciences
SubjectMemory disorders - Animal models
Kinesin
Dept/ProgramBiochemistry
Persistent Identifierhttp://hdl.handle.net/10722/193575

 

DC FieldValueLanguage
dc.contributor.authorLin, Yangjun-
dc.contributor.author林扬骏-
dc.date.accessioned2014-01-17T23:09:56Z-
dc.date.available2014-01-17T23:09:56Z-
dc.date.issued2013-
dc.identifier.citationLin, Y. [林扬骏]. (2013). Kif5b may play a role in impairing mouse memory : a behaviour and cellular study. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5091448-
dc.identifier.urihttp://hdl.handle.net/10722/193575-
dc.description.abstractAlzheimer's Disease is one of the most fearsome diseases worldwide. The study of Alzheimer's Disease (AD) is broad and many have focused on investigating the various proteins involved in neurons. A popular hypothesis of the cellular mechanism of AD is the accumulation of beta-Amyloid. Kinesin is a large group of motor proteins, which plays an extensive role in mitosis and intracellular cargo transport, including that of the Amyloid Protein Precursor. In the present study we have performed fear conditioning behaviour tests on Kif5b conditional knockout (CKO) mouse. Kif5b CKO mouse shows an impair contextual memory compared to the wild type, but does not display an impaired auditory memory. Heterozygous Kif5b knock out mouse shows no significant difference to the wild type. The study has also generated Kif5b fragments and used them to pull-down proteins in mouse brain lysate. The study has identified Clathrin and alpha-Adaptin as binding partners of Kif5b in mouse neuronal cells. The binding domain of Kif5b for these proteins is between amino acid residue 891-935. Finally this study has made a number of recommendations for further study.-
dc.languageeng-
dc.publisherThe University of Hong Kong (Pokfulam, Hong Kong)-
dc.relation.ispartofHKU Theses Online (HKUTO)-
dc.rightsThe author retains all proprietary rights, (such as patent rights) and the right to use in future works.-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.lcshMemory disorders - Animal models-
dc.subject.lcshKinesin-
dc.titleKif5b may play a role in impairing mouse memory : a behaviour and cellular study-
dc.typePG_Thesis-
dc.identifier.hkulb5091448-
dc.description.thesisnameMaster of Medical Sciences-
dc.description.thesislevelMaster-
dc.description.thesisdisciplineBiochemistry-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.5353/th_b5091448-
dc.date.hkucongregation2013-

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