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Conference Paper: Mechanistic study of the interactions between Id1-overexpressing esophageal cancer cells and fibroblasts in the tumor microenvironment

TitleMechanistic study of the interactions between Id1-overexpressing esophageal cancer cells and fibroblasts in the tumor microenvironment
Authors
Issue Date2013
PublisherNCRI Cancer Conference
Citation
The 9th National Cancer Research Institute (NCRI) Cancer Conference, Liverpool, UK., 3-6 November 2013. How to Cite?
AbstractBACKGROUND: Stromal fibroblast cells in the tumor microenvironment contribute to the development of cancer but the mechanisms of their interactions with cancer cells are not fully elucidated. Esophageal squamous cell carcinoma (ESCC) is the common type of esophageal cancer. It was reported that the majority of ESCC overexpress Id1 protein. METHOD: Human ESCC cell lines with ectopic expression of Id1, co-expression of Id1 and shIGF2, or empty vector(s) were established. In vitro assays including MTT, migration and invasion chamber assays were performed to investigate the proliferation, migration and invasive potential of cells. In vivo tumor xenografts were analyzed using immunohistochemistry, and in vivo bioluminescent imaging was used to monitor tumor metastasis in mice. Protein expressions were compared using Western blotting and ELISA ...
DescriptionPoster Session A - The cancer cell and model systems: no. A191
Persistent Identifierhttp://hdl.handle.net/10722/193266

 

DC FieldValueLanguage
dc.contributor.authorXu, Wen_US
dc.contributor.authorLi, Ben_US
dc.contributor.authorTsao, SWen_US
dc.contributor.authorChan, KWen_US
dc.contributor.authorCheung, ALMen_US
dc.date.accessioned2013-12-20T02:42:08Z-
dc.date.available2013-12-20T02:42:08Z-
dc.date.issued2013en_US
dc.identifier.citationThe 9th National Cancer Research Institute (NCRI) Cancer Conference, Liverpool, UK., 3-6 November 2013.en_US
dc.identifier.urihttp://hdl.handle.net/10722/193266-
dc.descriptionPoster Session A - The cancer cell and model systems: no. A191-
dc.description.abstractBACKGROUND: Stromal fibroblast cells in the tumor microenvironment contribute to the development of cancer but the mechanisms of their interactions with cancer cells are not fully elucidated. Esophageal squamous cell carcinoma (ESCC) is the common type of esophageal cancer. It was reported that the majority of ESCC overexpress Id1 protein. METHOD: Human ESCC cell lines with ectopic expression of Id1, co-expression of Id1 and shIGF2, or empty vector(s) were established. In vitro assays including MTT, migration and invasion chamber assays were performed to investigate the proliferation, migration and invasive potential of cells. In vivo tumor xenografts were analyzed using immunohistochemistry, and in vivo bioluminescent imaging was used to monitor tumor metastasis in mice. Protein expressions were compared using Western blotting and ELISA ...-
dc.languageengen_US
dc.publisherNCRI Cancer Conference-
dc.relation.ispartofNCRI Cancer Conferenceen_US
dc.titleMechanistic study of the interactions between Id1-overexpressing esophageal cancer cells and fibroblasts in the tumor microenvironmenten_US
dc.typeConference_Paperen_US
dc.identifier.emailLi, B: libinhku@hkucc.hku.hken_US
dc.identifier.emailTsao, SW: gswtsao@hku.hken_US
dc.identifier.emailChan, KW: hrmtckw@hku.hken_US
dc.identifier.emailCheung, ALM: lmcheung@hku.hken_US
dc.identifier.authorityTsao, SW=rp00399en_US
dc.description.naturelink_to_OA_fulltext-
dc.identifier.hkuros226965en_US
dc.publisher.placeUnited Kingdom-

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