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- Publisher Website: 10.1111/j.1365-3016.2009.01080.x
- Scopus: eid_2-s2.0-73649144232
- PMID: 20078834
- WOS: WOS:000273180300011
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Article: Neonatal sepsis, antibiotic therapy and later risk of asthma and allergy
Title | Neonatal sepsis, antibiotic therapy and later risk of asthma and allergy |
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Authors | |
Keywords | Antibiotics Asthma Eczema Hay fever Hygiene hypothesis Neonatal infection |
Issue Date | 2010 |
Citation | Paediatric and Perinatal Epidemiology, 2010, v. 24 n. 1, p. 88-92 How to Cite? |
Abstract | Neonatal sepsis and early antibiotic therapy affect bacterial colonisation and immune activation after birth. This could have implications for later risk of allergy and asthma. Using a validated questionnaire (International Study of Asthma and Allergies in Children, ISAAC), we screened for asthma and allergy in three cohorts (total n = 834; median age 12, range 7-23 years) with different perinatal exposures as regards infection and antibiotics. Asthma, but not hay fever, was more prevalent after neonatal sepsis with adjusted odds ratio (OR) 1.63 [;95% confidence interval (CI) 1.04, 2.56] and early antibiotic therapy (OR 1.48 [;0.93, 2.35]) as compared with a control group. There was a trend towards increased atopic eczema after neonatal sepsis (OR = 1.39 [;CI = 0.98, 1.98]). We conclude that neonatal sepsis is associated with an increased risk for later development of asthma. Early antibiotic exposure may contribute to this association. © 2010 Blackwell Publishing Ltd. |
Persistent Identifier | http://hdl.handle.net/10722/192700 |
ISSN | 2023 Impact Factor: 2.7 2023 SCImago Journal Rankings: 1.124 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Sobko, T | en_US |
dc.contributor.author | Schiött, J | en_US |
dc.contributor.author | Ehlin, A | en_US |
dc.contributor.author | Lundberg, J | en_US |
dc.contributor.author | Montgomery, S | en_US |
dc.contributor.author | Norman, M | en_US |
dc.date.accessioned | 2013-11-20T04:56:08Z | - |
dc.date.available | 2013-11-20T04:56:08Z | - |
dc.date.issued | 2010 | en_US |
dc.identifier.citation | Paediatric and Perinatal Epidemiology, 2010, v. 24 n. 1, p. 88-92 | en_US |
dc.identifier.issn | 0269-5022 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/192700 | - |
dc.description.abstract | Neonatal sepsis and early antibiotic therapy affect bacterial colonisation and immune activation after birth. This could have implications for later risk of allergy and asthma. Using a validated questionnaire (International Study of Asthma and Allergies in Children, ISAAC), we screened for asthma and allergy in three cohorts (total n = 834; median age 12, range 7-23 years) with different perinatal exposures as regards infection and antibiotics. Asthma, but not hay fever, was more prevalent after neonatal sepsis with adjusted odds ratio (OR) 1.63 [;95% confidence interval (CI) 1.04, 2.56] and early antibiotic therapy (OR 1.48 [;0.93, 2.35]) as compared with a control group. There was a trend towards increased atopic eczema after neonatal sepsis (OR = 1.39 [;CI = 0.98, 1.98]). We conclude that neonatal sepsis is associated with an increased risk for later development of asthma. Early antibiotic exposure may contribute to this association. © 2010 Blackwell Publishing Ltd. | en_US |
dc.language | eng | en_US |
dc.relation.ispartof | Paediatric and Perinatal Epidemiology | en_US |
dc.subject | Antibiotics | - |
dc.subject | Asthma | - |
dc.subject | Eczema | - |
dc.subject | Hay fever | - |
dc.subject | Hygiene hypothesis | - |
dc.subject | Neonatal infection | - |
dc.title | Neonatal sepsis, antibiotic therapy and later risk of asthma and allergy | en_US |
dc.type | Article | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1111/j.1365-3016.2009.01080.x | en_US |
dc.identifier.pmid | 20078834 | - |
dc.identifier.scopus | eid_2-s2.0-73649144232 | en_US |
dc.identifier.volume | 24 | en_US |
dc.identifier.issue | 1 | en_US |
dc.identifier.spage | 88 | en_US |
dc.identifier.epage | 92 | en_US |
dc.identifier.isi | WOS:000273180300011 | - |
dc.identifier.issnl | 0269-5022 | - |