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Article: Neonatal sepsis, antibiotic therapy and later risk of asthma and allergy

TitleNeonatal sepsis, antibiotic therapy and later risk of asthma and allergy
Authors
Issue Date2010
Citation
Paediatric and Perinatal Epidemiology, 2010, v. 24 n. 1, p. 88-92 How to Cite?
AbstractNeonatal sepsis and early antibiotic therapy affect bacterial colonisation and immune activation after birth. This could have implications for later risk of allergy and asthma. Using a validated questionnaire (International Study of Asthma and Allergies in Children, ISAAC), we screened for asthma and allergy in three cohorts (total n = 834; median age 12, range 7-23 years) with different perinatal exposures as regards infection and antibiotics. Asthma, but not hay fever, was more prevalent after neonatal sepsis with adjusted odds ratio (OR) 1.63 [;95% confidence interval (CI) 1.04, 2.56] and early antibiotic therapy (OR 1.48 [;0.93, 2.35]) as compared with a control group. There was a trend towards increased atopic eczema after neonatal sepsis (OR = 1.39 [;CI = 0.98, 1.98]). We conclude that neonatal sepsis is associated with an increased risk for later development of asthma. Early antibiotic exposure may contribute to this association. © 2010 Blackwell Publishing Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/192700
ISSN
2015 Impact Factor: 2.958
2015 SCImago Journal Rankings: 5.514
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorSobko, Ten_US
dc.contributor.authorSchiött, Jen_US
dc.contributor.authorEhlin, Aen_US
dc.contributor.authorLundberg, Jen_US
dc.contributor.authorMontgomery, Sen_US
dc.contributor.authorNorman, Men_US
dc.date.accessioned2013-11-20T04:56:08Z-
dc.date.available2013-11-20T04:56:08Z-
dc.date.issued2010en_US
dc.identifier.citationPaediatric and Perinatal Epidemiology, 2010, v. 24 n. 1, p. 88-92en_US
dc.identifier.issn0269-5022en_US
dc.identifier.urihttp://hdl.handle.net/10722/192700-
dc.description.abstractNeonatal sepsis and early antibiotic therapy affect bacterial colonisation and immune activation after birth. This could have implications for later risk of allergy and asthma. Using a validated questionnaire (International Study of Asthma and Allergies in Children, ISAAC), we screened for asthma and allergy in three cohorts (total n = 834; median age 12, range 7-23 years) with different perinatal exposures as regards infection and antibiotics. Asthma, but not hay fever, was more prevalent after neonatal sepsis with adjusted odds ratio (OR) 1.63 [;95% confidence interval (CI) 1.04, 2.56] and early antibiotic therapy (OR 1.48 [;0.93, 2.35]) as compared with a control group. There was a trend towards increased atopic eczema after neonatal sepsis (OR = 1.39 [;CI = 0.98, 1.98]). We conclude that neonatal sepsis is associated with an increased risk for later development of asthma. Early antibiotic exposure may contribute to this association. © 2010 Blackwell Publishing Ltd.en_US
dc.languageengen_US
dc.relation.ispartofPaediatric and Perinatal Epidemiologyen_US
dc.titleNeonatal sepsis, antibiotic therapy and later risk of asthma and allergyen_US
dc.typeArticleen_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1111/j.1365-3016.2009.01080.xen_US
dc.identifier.pmid20078834-
dc.identifier.scopuseid_2-s2.0-73649144232en_US
dc.identifier.volume24en_US
dc.identifier.issue1en_US
dc.identifier.spage88en_US
dc.identifier.epage92en_US
dc.identifier.isiWOS:000273180300011-

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