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Article: Intestinal hydrogen and nitric oxide gases in preterm infants - Effects of antibiotic therapy

TitleIntestinal hydrogen and nitric oxide gases in preterm infants - Effects of antibiotic therapy
Authors
Issue Date2008
Citation
Neonatology, 2008, v. 95 n. 1, p. 68-73 How to Cite?
AbstractObjective: Measurements of hydrogen (H 2) and nitric oxide (NO) levels in intestinal gas have recently been shown to be useful to monitor bacterial colonization in healthy term newborn infants. The significance of preterm birth and antibiotic therapy for intestinal gas production is not known and was the subject of this study. Methods: A minimally invasive tonometric technique was used for repeated measurements (44 samples) of luminal colonic H 2 and NO in 23 preterm infants with gestational age 27-35 weeks, birth weight 1,170-2,996 g and postnatal age 2-31 days. Results: The measuring procedure was well tolerated in all infants. Intestinal H 2 was 300 (4-1,990) ppm and NO was 34 (11-82) ppb. Intestinal H 2 and NO increased during the first week (p < 0.05) to average levels that in the case of H 2, exceeded those of healthy, term infants. In preterm infants treated with antibiotics (n = 12), H 2 and NO levels were significantly lower than in those without such therapy (p < 0.05). Conclusion: These observations suggest that intestinal measurements of H 2 and NO may be used to monitor birth-related bacterial colonization in relation to postnatal age, maturation and antibiotic therapy. In preterm infants, gaseous distension of the gut is common and may signal bacterial overgrowth. The potential role of intestinal gas measurements as a diagnostic tool for intestinal disorders remains to be clarified. Copyright © 2008 S. Karger AG.
Persistent Identifierhttp://hdl.handle.net/10722/192698
ISSN
2015 Impact Factor: 2.754
2015 SCImago Journal Rankings: 1.442
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorSobko, Ten_US
dc.contributor.authorElfström, Ken_US
dc.contributor.authorNavér, Len_US
dc.contributor.authorLundberg, JOen_US
dc.contributor.authorNorman, Men_US
dc.date.accessioned2013-11-20T04:56:07Z-
dc.date.available2013-11-20T04:56:07Z-
dc.date.issued2008en_US
dc.identifier.citationNeonatology, 2008, v. 95 n. 1, p. 68-73en_US
dc.identifier.issn1661-7800en_US
dc.identifier.urihttp://hdl.handle.net/10722/192698-
dc.description.abstractObjective: Measurements of hydrogen (H 2) and nitric oxide (NO) levels in intestinal gas have recently been shown to be useful to monitor bacterial colonization in healthy term newborn infants. The significance of preterm birth and antibiotic therapy for intestinal gas production is not known and was the subject of this study. Methods: A minimally invasive tonometric technique was used for repeated measurements (44 samples) of luminal colonic H 2 and NO in 23 preterm infants with gestational age 27-35 weeks, birth weight 1,170-2,996 g and postnatal age 2-31 days. Results: The measuring procedure was well tolerated in all infants. Intestinal H 2 was 300 (4-1,990) ppm and NO was 34 (11-82) ppb. Intestinal H 2 and NO increased during the first week (p < 0.05) to average levels that in the case of H 2, exceeded those of healthy, term infants. In preterm infants treated with antibiotics (n = 12), H 2 and NO levels were significantly lower than in those without such therapy (p < 0.05). Conclusion: These observations suggest that intestinal measurements of H 2 and NO may be used to monitor birth-related bacterial colonization in relation to postnatal age, maturation and antibiotic therapy. In preterm infants, gaseous distension of the gut is common and may signal bacterial overgrowth. The potential role of intestinal gas measurements as a diagnostic tool for intestinal disorders remains to be clarified. Copyright © 2008 S. Karger AG.en_US
dc.languageengen_US
dc.relation.ispartofNeonatologyen_US
dc.titleIntestinal hydrogen and nitric oxide gases in preterm infants - Effects of antibiotic therapyen_US
dc.typeArticleen_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1159/000151757en_US
dc.identifier.pmid18787339-
dc.identifier.scopuseid_2-s2.0-51349133576en_US
dc.identifier.volume95en_US
dc.identifier.issue1en_US
dc.identifier.spage68en_US
dc.identifier.epage73en_US
dc.identifier.isiWOS:000260682500009-

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