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Article: Inhibitory effect of silver diamine fluoride on dentine demineralisation and collagen degradation

TitleInhibitory effect of silver diamine fluoride on dentine demineralisation and collagen degradation
Authors
Issue Date2013
Citation
Journal of Dentistry, 2013, v. 41 n. 9, p. 809-817 How to Cite?
AbstractObjective To investigate the inhibitory effects of 38% silver diamine fluoride (SDF) on demineralised dentine. Methods Human dentine blocks were demineralised and allocated to four groups: SF, F, S and W. The blocks in group SF received a topical application of 38% SDF solution (253,900 ppm Ag, 44,800 ppm F), group F received a 10% sodium fluoride solution (44,800 ppm F), group S received a 42% silver nitrate solution (253,900 ppm Ag) and group W received deionised water (control). They were subjected to pH cycling using demineralisation solution (pH 5) and remineralisation solution (pH 7) for 8 days. The surface morphology, crystal characteristics, lesion depth and collagen matrix degradation of the specimens were investigated by scanning electron microscopy (SEM), X-ray diffraction (XRD), micro-CT testing and spectrophotometry with a hydroxyproline assay. Results The surface morphology under SEM showed evident demineralisation with exposed collagen in groups S and W, but not in group SF. Clusters of granular spherical grains were observed in the cross-sections of specimens in groups SF and F. XRD revealed precipitates of silver chloride in groups SF and S. The mean lesion depths (±SD) of groups SF, F, S and W were 182 ± 32 μm, 204 ± 26 μm, 259 ± 42 μm and 265 ± 40 μm, respectively (SDF, F < S, W; p < 0.01). Groups SF and S had significantly less hydroxyproline liberated from the dentine matrix than groups F and W (p < 0.01). Conclusion The use of 38% SDF inhibited demineralisation and preserved collagen from degradation in demineralised dentine. Clinical significance SDF application positively influences dentine remineralization.
Persistent Identifierhttp://hdl.handle.net/10722/192321
ISSN
2015 Impact Factor: 3.109
2015 SCImago Journal Rankings: 1.029
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorMei, MLen_US
dc.contributor.authorIto, Len_US
dc.contributor.authorCao, Yen_US
dc.contributor.authorLi, QLen_US
dc.contributor.authorLo, ECMen_US
dc.contributor.authorChu, CHen_US
dc.date.accessioned2013-10-24T01:49:30Z-
dc.date.available2013-10-24T01:49:30Z-
dc.date.issued2013en_US
dc.identifier.citationJournal of Dentistry, 2013, v. 41 n. 9, p. 809-817en_US
dc.identifier.issn0300-5712en_US
dc.identifier.urihttp://hdl.handle.net/10722/192321-
dc.description.abstractObjective To investigate the inhibitory effects of 38% silver diamine fluoride (SDF) on demineralised dentine. Methods Human dentine blocks were demineralised and allocated to four groups: SF, F, S and W. The blocks in group SF received a topical application of 38% SDF solution (253,900 ppm Ag, 44,800 ppm F), group F received a 10% sodium fluoride solution (44,800 ppm F), group S received a 42% silver nitrate solution (253,900 ppm Ag) and group W received deionised water (control). They were subjected to pH cycling using demineralisation solution (pH 5) and remineralisation solution (pH 7) for 8 days. The surface morphology, crystal characteristics, lesion depth and collagen matrix degradation of the specimens were investigated by scanning electron microscopy (SEM), X-ray diffraction (XRD), micro-CT testing and spectrophotometry with a hydroxyproline assay. Results The surface morphology under SEM showed evident demineralisation with exposed collagen in groups S and W, but not in group SF. Clusters of granular spherical grains were observed in the cross-sections of specimens in groups SF and F. XRD revealed precipitates of silver chloride in groups SF and S. The mean lesion depths (±SD) of groups SF, F, S and W were 182 ± 32 μm, 204 ± 26 μm, 259 ± 42 μm and 265 ± 40 μm, respectively (SDF, F < S, W; p < 0.01). Groups SF and S had significantly less hydroxyproline liberated from the dentine matrix than groups F and W (p < 0.01). Conclusion The use of 38% SDF inhibited demineralisation and preserved collagen from degradation in demineralised dentine. Clinical significance SDF application positively influences dentine remineralization.-
dc.languageengen_US
dc.relation.ispartofJournal of Dentistryen_US
dc.titleInhibitory effect of silver diamine fluoride on dentine demineralisation and collagen degradationen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.jdent.2013.06.009en_US
dc.identifier.pmid23810851-
dc.identifier.scopuseid_2-s2.0-84882454808en_US
dc.identifier.hkuros226325-
dc.identifier.hkuros228325-
dc.identifier.hkuros228324-
dc.identifier.volume41en_US
dc.identifier.issue9en_US
dc.identifier.spage809en_US
dc.identifier.epage817en_US
dc.identifier.isiWOS:000323767100008-

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