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Article: Spatiotemporal dynamics of diffusional kurtosis, mean diffusivity and perfusion changes in experimental stroke

TitleSpatiotemporal dynamics of diffusional kurtosis, mean diffusivity and perfusion changes in experimental stroke
Authors
Issue Date2012
Citation
Brain Research, 2012, v. 1451, p. 100-109 How to Cite?
AbstractDiffusional kurtosis imaging (DKI), which measures the non-Gaussianity of water diffusion, has been demonstrated to be a sensitive biomarker in many neuropathologies. The goal of this study was to longitudinally examine the spatiotemporal dynamics of DKI in cerebral ischemia in an animal model of permanent and transient (45 min) middle cerebral artery occlusion (MCAO) during the hyperacute, acute and chronic phases. Diffusional kurtosis showed different spatiotemporal dynamics. In particular, mean kurtosis (MK) was sensitive to hyperacute and acute stroke changes, and exhibited different contrast than mean diffusivity (MD) and higher contrast than fractional anisotropy (FA) and T2. MK contrast persisted 1 to 7 days post-occlusion, whereas MD showed renormalization at day 1–2 and reversed contrast at day 7. The current study showed that DKI has the potential to complement existing stroke imaging techniques, particularly in the assessment of subacute to early chronic stroke evolution.
Persistent Identifierhttp://hdl.handle.net/10722/192105
ISSN
2015 Impact Factor: 2.561
2015 SCImago Journal Rankings: 1.351
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorHui, ESen_US
dc.contributor.authorDu, Fen_US
dc.contributor.authorHuang, Sen_US
dc.contributor.authorShen, Qen_US
dc.contributor.authorDuong, TQen_US
dc.date.accessioned2013-10-23T09:25:33Z-
dc.date.available2013-10-23T09:25:33Z-
dc.date.issued2012en_US
dc.identifier.citationBrain Research, 2012, v. 1451, p. 100-109en_US
dc.identifier.issn0006-8993en_US
dc.identifier.urihttp://hdl.handle.net/10722/192105-
dc.description.abstractDiffusional kurtosis imaging (DKI), which measures the non-Gaussianity of water diffusion, has been demonstrated to be a sensitive biomarker in many neuropathologies. The goal of this study was to longitudinally examine the spatiotemporal dynamics of DKI in cerebral ischemia in an animal model of permanent and transient (45 min) middle cerebral artery occlusion (MCAO) during the hyperacute, acute and chronic phases. Diffusional kurtosis showed different spatiotemporal dynamics. In particular, mean kurtosis (MK) was sensitive to hyperacute and acute stroke changes, and exhibited different contrast than mean diffusivity (MD) and higher contrast than fractional anisotropy (FA) and T2. MK contrast persisted 1 to 7 days post-occlusion, whereas MD showed renormalization at day 1–2 and reversed contrast at day 7. The current study showed that DKI has the potential to complement existing stroke imaging techniques, particularly in the assessment of subacute to early chronic stroke evolution.-
dc.languageengen_US
dc.relation.ispartofBrain Researchen_US
dc.subject.meshAnimals-
dc.subject.meshAnisotropy-
dc.subject.meshCerebrovascular Circulation-
dc.subject.meshDiffusion Magnetic Resonance Imaging-
dc.subject.meshInfarction-
dc.titleSpatiotemporal dynamics of diffusional kurtosis, mean diffusivity and perfusion changes in experimental strokeen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.brainres.2012.02.044en_US
dc.identifier.pmid22444274-
dc.identifier.scopuseid_2-s2.0-84862789339en_US
dc.identifier.volume1451en_US
dc.identifier.spage100en_US
dc.identifier.epage109en_US
dc.identifier.isiWOS:000304128100011-

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