File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Prognostic factors in papillary and follicular thyroid carcinoma: Their implications for cancer staging

TitlePrognostic factors in papillary and follicular thyroid carcinoma: Their implications for cancer staging
Authors
Issue Date2007
PublisherSpringer New York LLC. The Journal's web site is located at http://www.annalssurgicaloncology.org
Citation
Annals of Surgical Oncology, 2007, v. 14 n. 2, p. 730-738 How to Cite?
AbstractBACKGROUND: Papillary thyroid carcinoma (PTC) and follicular thyroid carcinoma (FTC) are two distinct histological types of thyroid carcinoma but have often been studied and staged as a collective group, known as differentiated thyroid carcinoma (DTC). However, this may not be an optimal approach to cancer staging. METHODS: A total of 760 patients with DTC, comprising 589 (77.5%) with PTC and 171 with (22.5%) FTC, being managed at our institution from 1961 to 2001 were retrospectively reviewed. Their clinicopathological features, treatment modalities received, and postoperative outcome were analyzed. Both univariate and multivariate analyses were performed to identify prognostic factors related to cancer-specific survival (CSS) for PTC and FTC. RESULTS: There were statistically significant differences between PTC and FTC in terms of age >/=50 years at diagnosis (P = .040), tumor size (P < .001), lymph node metastases (P < .001), distant metastases (P < .001), extrathyroidal extension (P < .001), multifocality (P = .002), capsular invasion (P < .001), extent of thyroid resection (P < .001), radioiodine ablation (P < .001), and external-beam irradiation (P = .003). Although PTC and FTC had similar 10-year and 15-year CSS (P = .846), each possessed its own set of independent prognostic factors for CSS. Age at diagnosis and completeness of resection were independent prognostic factors in both PTC and FTC. CONCLUSIONS: There were marked differences in clinicopathologic features, treatment, and prognostic factors between the two histologic types of DTC. Different staging systems should be evaluated and validated for PTC and FTC individually in the future.
Persistent Identifierhttp://hdl.handle.net/10722/192070
ISSN
2015 Impact Factor: 3.655
2015 SCImago Journal Rankings: 1.902
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLang, BHH-
dc.contributor.authorLo, CY-
dc.contributor.authorChan, WF-
dc.contributor.authorLam, KY-
dc.contributor.authorWan, KY-
dc.date.accessioned2013-10-17T01:49:21Z-
dc.date.available2013-10-17T01:49:21Z-
dc.date.issued2007-
dc.identifier.citationAnnals of Surgical Oncology, 2007, v. 14 n. 2, p. 730-738-
dc.identifier.issn1068-9265-
dc.identifier.urihttp://hdl.handle.net/10722/192070-
dc.description.abstractBACKGROUND: Papillary thyroid carcinoma (PTC) and follicular thyroid carcinoma (FTC) are two distinct histological types of thyroid carcinoma but have often been studied and staged as a collective group, known as differentiated thyroid carcinoma (DTC). However, this may not be an optimal approach to cancer staging. METHODS: A total of 760 patients with DTC, comprising 589 (77.5%) with PTC and 171 with (22.5%) FTC, being managed at our institution from 1961 to 2001 were retrospectively reviewed. Their clinicopathological features, treatment modalities received, and postoperative outcome were analyzed. Both univariate and multivariate analyses were performed to identify prognostic factors related to cancer-specific survival (CSS) for PTC and FTC. RESULTS: There were statistically significant differences between PTC and FTC in terms of age >/=50 years at diagnosis (P = .040), tumor size (P < .001), lymph node metastases (P < .001), distant metastases (P < .001), extrathyroidal extension (P < .001), multifocality (P = .002), capsular invasion (P < .001), extent of thyroid resection (P < .001), radioiodine ablation (P < .001), and external-beam irradiation (P = .003). Although PTC and FTC had similar 10-year and 15-year CSS (P = .846), each possessed its own set of independent prognostic factors for CSS. Age at diagnosis and completeness of resection were independent prognostic factors in both PTC and FTC. CONCLUSIONS: There were marked differences in clinicopathologic features, treatment, and prognostic factors between the two histologic types of DTC. Different staging systems should be evaluated and validated for PTC and FTC individually in the future.-
dc.languageeng-
dc.publisherSpringer New York LLC. The Journal's web site is located at http://www.annalssurgicaloncology.org-
dc.relation.ispartofAnnals of Surgical Oncology-
dc.rightsThe original publication is available at www.springerlink.com-
dc.subject.meshAdenocarcinoma, Follicular - pathology - therapy-
dc.subject.meshAdenocarcinoma, Papillary - pathology - therapy-
dc.subject.meshIodine Radioisotopes - therapeutic use-
dc.subject.meshNeoplasm Staging - methods-
dc.subject.meshThyroid Neoplasms - pathology - therapy-
dc.titlePrognostic factors in papillary and follicular thyroid carcinoma: Their implications for cancer stagingen_US
dc.typeArticleen_US
dc.identifier.emailLang, BHH: blang@HKUCC.hku.hk-
dc.identifier.emailLo, CY: cylo@hkucc.hku.hk-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1245/s10434-006-9207-5-
dc.identifier.pmid17103065-
dc.identifier.scopuseid_2-s2.0-33846649564-
dc.identifier.hkuros135172-
dc.identifier.volume14-
dc.identifier.issue2-
dc.identifier.spage730-
dc.identifier.epage738-
dc.identifier.isiWOS:000243765500062-
dc.publisher.placeUnited States-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats