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Article: Staging systems for papillary thyroid carcinoma: A review and comparison

TitleStaging systems for papillary thyroid carcinoma: A review and comparison
Authors
Issue Date2007
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.annalsofsurgery.com
Citation
Annals of Surgery, 2007, v. 245 n. 3, p. 366-378 How to Cite?
AbstractOBJECTIVE: To find out the most predictive staging system for papillary thyroid carcinoma (PTC) currently available in the literature. BACKGROUND: Various staging systems or risk group stratifications have been used extensively in the clinical management of patients with PTC, but the most predictive system for cancer-specific survival (CSS) based on distinct histologic types remains unclear. METHODS: Through a comprehensive MEDLINE search from 1965 to 2005, a total of 17 staging systems were found in the literature and 14 systems were applied to the 589 PTC patients managed at our institution from 1961 to 2001. CSS were calculated by Kaplan-Meier method and were compared by log-rank test. Using Cox proportional hazards analysis, the relative importance of each staging system in determining CSS was calculated by the proportion of variation (PVE). RESULTS: All 14 staging systems significantly predicted CSS (P < 0.001). The 3 highest ranked staging systems by PVE were the Metastases, Age, Completeness of Resection, Invasion, Size (MACIS) (18.7) followed by the new AJCC/UICC 6th edition tumor, node, metastases (TNM) (17.9), and the European Organization for Research and Treatment of Cancer (EORTC) (16.6). CONCLUSIONS: All of the currently available staging systems predicted CSS well in patients with PTC regardless of which histologic type from which they were derived. When predictability was measured by PVE, the MACIS system was the most predictive staging system and so should be the staging system of choice for PTC in the future.
Persistent Identifierhttp://hdl.handle.net/10722/192068
ISSN
2015 Impact Factor: 8.569
2015 SCImago Journal Rankings: 4.503
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLang, BHH-
dc.contributor.authorLo, CY-
dc.contributor.authorChan, WF-
dc.contributor.authorLam, KY-
dc.contributor.authorWan, KY-
dc.date.accessioned2013-10-17T01:29:44Z-
dc.date.available2013-10-17T01:29:44Z-
dc.date.issued2007-
dc.identifier.citationAnnals of Surgery, 2007, v. 245 n. 3, p. 366-378-
dc.identifier.issn0003-4932-
dc.identifier.urihttp://hdl.handle.net/10722/192068-
dc.description.abstractOBJECTIVE: To find out the most predictive staging system for papillary thyroid carcinoma (PTC) currently available in the literature. BACKGROUND: Various staging systems or risk group stratifications have been used extensively in the clinical management of patients with PTC, but the most predictive system for cancer-specific survival (CSS) based on distinct histologic types remains unclear. METHODS: Through a comprehensive MEDLINE search from 1965 to 2005, a total of 17 staging systems were found in the literature and 14 systems were applied to the 589 PTC patients managed at our institution from 1961 to 2001. CSS were calculated by Kaplan-Meier method and were compared by log-rank test. Using Cox proportional hazards analysis, the relative importance of each staging system in determining CSS was calculated by the proportion of variation (PVE). RESULTS: All 14 staging systems significantly predicted CSS (P < 0.001). The 3 highest ranked staging systems by PVE were the Metastases, Age, Completeness of Resection, Invasion, Size (MACIS) (18.7) followed by the new AJCC/UICC 6th edition tumor, node, metastases (TNM) (17.9), and the European Organization for Research and Treatment of Cancer (EORTC) (16.6). CONCLUSIONS: All of the currently available staging systems predicted CSS well in patients with PTC regardless of which histologic type from which they were derived. When predictability was measured by PVE, the MACIS system was the most predictive staging system and so should be the staging system of choice for PTC in the future.-
dc.languageeng-
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.annalsofsurgery.com-
dc.relation.ispartofAnnals of Surgery-
dc.subject.meshCarcinoma, Papillary - mortality - pathology - surgery-
dc.subject.meshLymphatic Metastasis-
dc.subject.meshNeoplasm Invasiveness-
dc.subject.meshNeoplasm Staging - methods-
dc.subject.meshThyroid Neoplasms - mortality - pathology - surgery-
dc.titleStaging systems for papillary thyroid carcinoma: A review and comparisonen_US
dc.typeArticleen_US
dc.identifier.emailLang, BHH: blang@hkucc.hku.hk-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1097/01.sla.0000250445.92336.2a-
dc.identifier.pmid17435543-
dc.identifier.pmcidPMC1877011-
dc.identifier.scopuseid_2-s2.0-34247614170-
dc.identifier.hkuros126638-
dc.identifier.volume245-
dc.identifier.issue3-
dc.identifier.spage366-
dc.identifier.epage378-
dc.identifier.isiWOS:000244515300007-
dc.publisher.placeUnited States-

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