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Article: Surgical options in undifferentiated thyroid carcinoma

TitleSurgical options in undifferentiated thyroid carcinoma
Authors
Issue Date2007
PublisherSpringer New York LLC. The Journal's web site is located at http://link.springer.de/link/service/journals/00268/
Citation
World Journal of Surgery, 2007, v. 31 n. 5, p. 969-977 How to Cite?
AbstractUndifferentiated or anaplastic carcinoma is an uncommon histologic type of thyroid cancer. It is one of the most aggressive malignancies associated with a poor prognosis. Most patients are elderly presenting as locally advanced disease with nodal and distant metastases. Complete surgical resection is frequently not possible and there is no effective systemic therapy. Aggressive multimodal therapy including surgery, radiation, and chemotherapy is recommended for management. However, because of the rarity of the disease, its aggressiveness and the lack of prospective treatment protocols, nearly all evidence in the literature comes from retrospective case series or cohort studies for selected patients' subgroups treated over a relatively long study period. Evidence of therapeutic benefit of one treatment option over another is lacking. Prognosis remains dismal with a median survival of 2-12 months Surgery remains an important component of the multimodal therapy and is commonly adopted as primary treatment. Although radical resection should be discouraged, resection without inducing significant morbidity can be considered for good risk patients with resectable tumors. It provides an effective form of palliation with potential cure when combined with postoperative radiotherapy and/or chemotherapy. Patients selected for surgical resection was frequently identified to have improved survival. A regime of preoperative hyperfractionated radiotherapy and doxorubicin followed by surgery when feasible has been documented to achieve local control and avoid tracheostomy for ATC patients. Because of the ineffectiveness of all conventional treatment modalities, novel molecular targeted therapies are being developed to tackling this uniformly fatal disease with promising results.
Persistent Identifierhttp://hdl.handle.net/10722/192066
ISSN
2015 Impact Factor: 2.523
2015 SCImago Journal Rankings: 1.375
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLang, BHH-
dc.contributor.authorLo, CY-
dc.date.accessioned2013-10-17T01:10:55Z-
dc.date.available2013-10-17T01:10:55Z-
dc.date.issued2007-
dc.identifier.citationWorld Journal of Surgery, 2007, v. 31 n. 5, p. 969-977-
dc.identifier.issn0364-2313-
dc.identifier.urihttp://hdl.handle.net/10722/192066-
dc.description.abstractUndifferentiated or anaplastic carcinoma is an uncommon histologic type of thyroid cancer. It is one of the most aggressive malignancies associated with a poor prognosis. Most patients are elderly presenting as locally advanced disease with nodal and distant metastases. Complete surgical resection is frequently not possible and there is no effective systemic therapy. Aggressive multimodal therapy including surgery, radiation, and chemotherapy is recommended for management. However, because of the rarity of the disease, its aggressiveness and the lack of prospective treatment protocols, nearly all evidence in the literature comes from retrospective case series or cohort studies for selected patients' subgroups treated over a relatively long study period. Evidence of therapeutic benefit of one treatment option over another is lacking. Prognosis remains dismal with a median survival of 2-12 months Surgery remains an important component of the multimodal therapy and is commonly adopted as primary treatment. Although radical resection should be discouraged, resection without inducing significant morbidity can be considered for good risk patients with resectable tumors. It provides an effective form of palliation with potential cure when combined with postoperative radiotherapy and/or chemotherapy. Patients selected for surgical resection was frequently identified to have improved survival. A regime of preoperative hyperfractionated radiotherapy and doxorubicin followed by surgery when feasible has been documented to achieve local control and avoid tracheostomy for ATC patients. Because of the ineffectiveness of all conventional treatment modalities, novel molecular targeted therapies are being developed to tackling this uniformly fatal disease with promising results.-
dc.languageeng-
dc.publisherSpringer New York LLC. The Journal's web site is located at http://link.springer.de/link/service/journals/00268/-
dc.relation.ispartofWorld Journal of Surgery-
dc.rightsThe original publication is available at www.springerlink.com-
dc.subject.meshCarcinoma - drug therapy - radiotherapy - surgery-
dc.subject.meshPrognosis-
dc.subject.meshSurvival Analysis-
dc.subject.meshThyroid Neoplasms - drug therapy - radiotherapy - surgery-
dc.subject.meshThyroidectomy - methods-
dc.titleSurgical options in undifferentiated thyroid carcinomaen_US
dc.typeArticleen_US
dc.identifier.emailLang, BHH: blang@HKUCC.hku.hk-
dc.identifier.emailLo, CY: cylo@hkucc.hku.hk-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/s00268-007-0776-7-
dc.identifier.pmid17483987-
dc.identifier.scopuseid_2-s2.0-34248203755-
dc.identifier.hkuros127657-
dc.identifier.hkuros226728-
dc.identifier.volume31-
dc.identifier.issue5-
dc.identifier.spage969-
dc.identifier.epage977-
dc.identifier.isiWOS:000246234500011-
dc.publisher.placeUnited States-

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