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Article: Cyclooxygenase-1 mediated platelet reactivity in young male smokers

TitleCyclooxygenase-1 mediated platelet reactivity in young male smokers
Authors
KeywordsAtherosclerosis
Platelet dysfunction
Platelet function
Vascular disease
Issue Date2012
PublisherSage Publications, Inc. The Journal's web site is located at http://cat.sagepub.com
Citation
Clinical and Applied Thrombosis/Hemostasis, 2012, v. 20 n. 4, p. 371-377 How to Cite?
AbstractBackground: The purpose of this study is to investigate the acute and chronic effects of cigarette smoking on cyclooxygenase- 1(COX-1)-mediated platelet reactivity among cigarette smokers. Methods: The levels of collagen-induced platelet aggregation, platelet COX-1 activity, and expressions were compared between smokers and age-matched nonsmokers. In smokers, the acute effects of cigarette smoking were assessed by repeating these measurements an hour after smoking. Results: Twenty-five smokers and age-matched nonsmokers (all men; mean age, 29 years) were studied. Collagen-induced platelet aggregation and plasma/urinary thromboxane B2 (TXB2) and 11-dehydroxythromboxane B2 levels were higher in cigarette smokers compared to nonsmokers. Greater expression of platelet COX-1 was observed in smokers than in nonsmokers. Among smokers, collagen-induced platelet aggregation correlated positively with platelet volume and circulating nicotine and cotinine concentrations. The levels of plasma/urinary TXB2 were significantly increased an hour after cigarette smoking. Conclusion: Cigarette smoking aggravates COX-1-mediated platelet reactivity in young, otherwise healthy, smoking men.
Persistent Identifierhttp://hdl.handle.net/10722/191796
ISSN
2015 Impact Factor: 1.973
2015 SCImago Journal Rankings: 0.517
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLoke, WMen_US
dc.contributor.authorLam, KMSen_US
dc.contributor.authorLee, CYJen_US
dc.contributor.authorChong, WLen_US
dc.contributor.authorSoh, ECen_US
dc.contributor.authorHuang, Hen_US
dc.contributor.authorLooi, WFen_US
dc.contributor.authorQuek, AMLen_US
dc.contributor.authorLim, ECHen_US
dc.contributor.authorSeet, RCSen_US
dc.date.accessioned2013-10-15T07:24:35Z-
dc.date.available2013-10-15T07:24:35Z-
dc.date.issued2012en_US
dc.identifier.citationClinical and Applied Thrombosis/Hemostasis, 2012, v. 20 n. 4, p. 371-377en_US
dc.identifier.issn1076-0296-
dc.identifier.urihttp://hdl.handle.net/10722/191796-
dc.description.abstractBackground: The purpose of this study is to investigate the acute and chronic effects of cigarette smoking on cyclooxygenase- 1(COX-1)-mediated platelet reactivity among cigarette smokers. Methods: The levels of collagen-induced platelet aggregation, platelet COX-1 activity, and expressions were compared between smokers and age-matched nonsmokers. In smokers, the acute effects of cigarette smoking were assessed by repeating these measurements an hour after smoking. Results: Twenty-five smokers and age-matched nonsmokers (all men; mean age, 29 years) were studied. Collagen-induced platelet aggregation and plasma/urinary thromboxane B2 (TXB2) and 11-dehydroxythromboxane B2 levels were higher in cigarette smokers compared to nonsmokers. Greater expression of platelet COX-1 was observed in smokers than in nonsmokers. Among smokers, collagen-induced platelet aggregation correlated positively with platelet volume and circulating nicotine and cotinine concentrations. The levels of plasma/urinary TXB2 were significantly increased an hour after cigarette smoking. Conclusion: Cigarette smoking aggravates COX-1-mediated platelet reactivity in young, otherwise healthy, smoking men.-
dc.languageengen_US
dc.publisherSage Publications, Inc. The Journal's web site is located at http://cat.sagepub.comen_US
dc.relation.ispartofClinical and Applied Thrombosis/Hemostasisen_US
dc.rightsClinical and Applied Thrombosis/Hemostasis. Copyright © Sage Publications, Inc.en_US
dc.subjectAtherosclerosis-
dc.subjectPlatelet dysfunction-
dc.subjectPlatelet function-
dc.subjectVascular disease-
dc.titleCyclooxygenase-1 mediated platelet reactivity in young male smokersen_US
dc.typeArticleen_US
dc.identifier.emailLee, CYJ: jettylee@hku.hken_US
dc.identifier.authorityLee, CYJ=rp01511en_US
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1177/1076029612466284-
dc.identifier.pmid23242413-
dc.identifier.hkuros225507en_US
dc.identifier.hkuros213782-
dc.identifier.volume20-
dc.identifier.issue4-
dc.identifier.spage371-
dc.identifier.epage377-
dc.identifier.isiWOS:000333743400004-
dc.publisher.placeUnited States-

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