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Conference Paper: Brain grey matter changes in young patients with mild type of essential arms tremor: a voxel-based morphometry MRI study

TitleBrain grey matter changes in young patients with mild type of essential arms tremor: a voxel-based morphometry MRI study
Authors
Issue Date2013
PublisherInternational Society for Magnetic Resonance in Medicine (ISMRM).
Citation
The 21st Annual Meeting & Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2013), Salt Lake City, UT., 20-26 April 2013. In Society of Magnetic Resonance in Medicine Proceedings, 2013, v. 21, p. 1028 How to Cite?
AbstractEssential tremor (ET) is common neurological movement disorders and may be related to cerebella dysregulation. The variation of grey matter (GM) in ET patients has remained uncertain from previous MRI studies, especially in mild type of essential arms tremor (a-ET). In this MRI study, voxel-based morphometry (VBM) method was used to detect the morphological changes of GM in 8 young patients with mild a-ET with respect to 8 healthy subjects. The mild a-ET patients exhibited the decrease of GM density in bilateral parietal lobe and the increase in GM density in bilateral cerebellum, occipital lobe and temporal occipital fusiform cortex. These findings may be associated with the network changes of cerebelo-thalamo-cortical loop in mild a-ET. The atrophy of GM in bilateral parietal lobe might represent the diminished capacity of spatial erientation and proprioceptive sensibility in a-ET patients. Moreover, mild a-ET shows a relative expansion of GM areas involved in higher order visuospatial processing, which might represent the adaptive reorganizational compensating through the increased demand on the visuospatial control of skilled movements in the early stage of a-ET. These morphological changes may help to assess early stage and distinguish subtype of ET. (Abstract by ISMRM)
DescriptionTraditional Poster Session: Neuro A - Movement Disorders & Degeneration
Persistent Identifierhttp://hdl.handle.net/10722/191660
ISSN

 

DC FieldValueLanguage
dc.contributor.authorCao, HMen_US
dc.contributor.authorWang, Ren_US
dc.contributor.authorLuo, Xen_US
dc.contributor.authorZhang, Zen_US
dc.contributor.authorLi, XJen_US
dc.contributor.authorQu, QMen_US
dc.contributor.authorWu, EXen_US
dc.contributor.authorYang, Jen_US
dc.date.accessioned2013-10-15T07:14:57Z-
dc.date.available2013-10-15T07:14:57Z-
dc.date.issued2013en_US
dc.identifier.citationThe 21st Annual Meeting & Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2013), Salt Lake City, UT., 20-26 April 2013. In Society of Magnetic Resonance in Medicine Proceedings, 2013, v. 21, p. 1028en_US
dc.identifier.issn1557-3672-
dc.identifier.urihttp://hdl.handle.net/10722/191660-
dc.descriptionTraditional Poster Session: Neuro A - Movement Disorders & Degeneration-
dc.description.abstractEssential tremor (ET) is common neurological movement disorders and may be related to cerebella dysregulation. The variation of grey matter (GM) in ET patients has remained uncertain from previous MRI studies, especially in mild type of essential arms tremor (a-ET). In this MRI study, voxel-based morphometry (VBM) method was used to detect the morphological changes of GM in 8 young patients with mild a-ET with respect to 8 healthy subjects. The mild a-ET patients exhibited the decrease of GM density in bilateral parietal lobe and the increase in GM density in bilateral cerebellum, occipital lobe and temporal occipital fusiform cortex. These findings may be associated with the network changes of cerebelo-thalamo-cortical loop in mild a-ET. The atrophy of GM in bilateral parietal lobe might represent the diminished capacity of spatial erientation and proprioceptive sensibility in a-ET patients. Moreover, mild a-ET shows a relative expansion of GM areas involved in higher order visuospatial processing, which might represent the adaptive reorganizational compensating through the increased demand on the visuospatial control of skilled movements in the early stage of a-ET. These morphological changes may help to assess early stage and distinguish subtype of ET. (Abstract by ISMRM)-
dc.languageengen_US
dc.publisherInternational Society for Magnetic Resonance in Medicine (ISMRM).-
dc.relation.ispartofSociety of Magnetic Resonance in Medicine Proceedingsen_US
dc.titleBrain grey matter changes in young patients with mild type of essential arms tremor: a voxel-based morphometry MRI studyen_US
dc.typeConference_Paperen_US
dc.identifier.emailWu, EX: ewu1@hkucc.hku.hken_US
dc.identifier.authorityWu, EX=rp00193en_US
dc.description.naturelink_to_OA_fulltext-
dc.identifier.hkuros226052en_US
dc.identifier.volume21-
dc.identifier.spage1028en_US
dc.identifier.epage1028en_US
dc.publisher.placeUnited Statesen_US

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