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Conference Paper: In vivo diffusion assessment of intramyocellular lipid droplet size changes associated with high-fat diet induced obesity and streptozotocin induced diabetes

TitleIn vivo diffusion assessment of intramyocellular lipid droplet size changes associated with high-fat diet induced obesity and streptozotocin induced diabetes
Authors
Issue Date2013
PublisherISMRM.
Citation
The 21st Annual Meeting & Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2013), Salt Lake City, UT., 20-26 April 2013. In Society of Magnetic Resonance in Medicine Proceedings, 2013, v. 21, p. 0360 How to Cite?
AbstractIntramyocellular lipid (IMCL) serves as the principal reservoir for storing cellular energy in muscles. Mounting evidence indicates that elevated IMCL in skeletal muscle is closely associated with insulin resistance and type 2 diabetes. Our experimental results demonstrated that in vivo IMCL ADC can differentiate high fat diet induced obesity and STZ induced diabetes. In diabetic model, IMCL level increased but exhibited more restricted diffusion. In obesity model, the IMCL level increased but the droplet size didn't change. Diffusion measurements were largely in agreement with our histological observation. Such an MR approach may provide a new dimension in the study of intracellular lipogenesis and lipolysis, and lead to improved understanding and diagnosis in treatment and management of several prevalent metabolic disorders such as obesity and diabetes in both basic and clinical sciences. (Abstract by ISMRM)
DescriptionScientific Session - Muscle: Physiology & Function
ISMRM Merit Award: Magna cum Laude
Persistent Identifierhttp://hdl.handle.net/10722/191632
ISSN

 

DC FieldValueLanguage
dc.contributor.authorCao, Pen_US
dc.contributor.authorWang, AMen_US
dc.contributor.authorXie, VBen_US
dc.contributor.authorFan, SJen_US
dc.contributor.authorQiao, ZWen_US
dc.contributor.authorWu, EXen_US
dc.date.accessioned2013-10-15T07:14:46Z-
dc.date.available2013-10-15T07:14:46Z-
dc.date.issued2013en_US
dc.identifier.citationThe 21st Annual Meeting & Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2013), Salt Lake City, UT., 20-26 April 2013. In Society of Magnetic Resonance in Medicine Proceedings, 2013, v. 21, p. 0360en_US
dc.identifier.issn1557-3672-
dc.identifier.urihttp://hdl.handle.net/10722/191632-
dc.descriptionScientific Session - Muscle: Physiology & Function-
dc.descriptionISMRM Merit Award: Magna cum Laude-
dc.description.abstractIntramyocellular lipid (IMCL) serves as the principal reservoir for storing cellular energy in muscles. Mounting evidence indicates that elevated IMCL in skeletal muscle is closely associated with insulin resistance and type 2 diabetes. Our experimental results demonstrated that in vivo IMCL ADC can differentiate high fat diet induced obesity and STZ induced diabetes. In diabetic model, IMCL level increased but exhibited more restricted diffusion. In obesity model, the IMCL level increased but the droplet size didn't change. Diffusion measurements were largely in agreement with our histological observation. Such an MR approach may provide a new dimension in the study of intracellular lipogenesis and lipolysis, and lead to improved understanding and diagnosis in treatment and management of several prevalent metabolic disorders such as obesity and diabetes in both basic and clinical sciences. (Abstract by ISMRM)-
dc.languageengen_US
dc.publisherISMRM.-
dc.relation.ispartofSociety of Magnetic Resonance in Medicine Proceedingsen_US
dc.titleIn vivo diffusion assessment of intramyocellular lipid droplet size changes associated with high-fat diet induced obesity and streptozotocin induced diabetesen_US
dc.typeConference_Paperen_US
dc.identifier.emailWu, EX: ewu1@hkucc.hku.hken_US
dc.identifier.authorityWu, EX=rp00193en_US
dc.description.naturelink_to_OA_fulltext-
dc.identifier.hkuros225984en_US
dc.identifier.volume21-
dc.identifier.spage0360en_US
dc.identifier.epage0360en_US
dc.publisher.placeUnited Statesen_US

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