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Article: New treatments for bacterial keratitis

TitleNew treatments for bacterial keratitis
Authors
Issue Date2012
PublisherHindawi Publishing Corporation. The Journal's web site is located at http://www.hindawi.com/journals/jop
Citation
Journal of Ophthalmology, 2012, v. 2012, article no. 831502 How to Cite?
AbstractPurpose. To review the newer treatments for bacterial keratitis. Data Sources. PubMed literature search up to April 2012. Study Selection. Key words used for literature search: 'infectious keratitis', 'microbial keratitis', 'infective keratitis', 'new treatments for infectious keratitis', 'fourth generation fluoroquinolones', 'moxifloxacin', 'gatifloxacin', 'collagen cross-linking', and 'photodynamic therapy'. Data Extraction. Over 2400 articles were retrieved. Large scale studies or publications at more recent dates were selected. Data Synthesis. Broad spectrum antibiotics have been the main stay of treatment for bacterial keratitis but with the emergence of bacterial resistance; there is a need for newer antimicrobial agents and treatment methods. Fourth-generation fluoroquinolones and corneal collagen cross-linking are amongst the new treatments. In vitro studies and prospective clinical trials have shown that fourth-generation fluoroquinolones are better than the older generation fluoroquinolones and are as potent as combined fortified antibiotics against common pathogens that cause bacterial keratitis. Collagen cross-linking was shown to improve healing of infectious corneal ulcer in treatment-resistant cases or as an adjunct to antibiotics treatment. Conclusion. Fourth-generation fluoroquinolones are good alternatives to standard treatment of bacterial keratitis using combined fortified topical antibiotics. Collagen cross-linking may be considered in treatment-resistant infectious keratitis or as an adjunct to antibiotics therapy.
Persistent Identifierhttp://hdl.handle.net/10722/191102
ISSN
2015 Impact Factor: 1.463
2015 SCImago Journal Rankings: 0.870
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWong, RLMen_US
dc.contributor.authorGangwani, RAen_US
dc.contributor.authorYu, LWHen_US
dc.contributor.authorLai, JSMen_US
dc.date.accessioned2013-09-17T16:16:25Z-
dc.date.available2013-09-17T16:16:25Z-
dc.date.issued2012en_US
dc.identifier.citationJournal of Ophthalmology, 2012, v. 2012, article no. 831502en_US
dc.identifier.issn2090-004Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/191102-
dc.description.abstractPurpose. To review the newer treatments for bacterial keratitis. Data Sources. PubMed literature search up to April 2012. Study Selection. Key words used for literature search: 'infectious keratitis', 'microbial keratitis', 'infective keratitis', 'new treatments for infectious keratitis', 'fourth generation fluoroquinolones', 'moxifloxacin', 'gatifloxacin', 'collagen cross-linking', and 'photodynamic therapy'. Data Extraction. Over 2400 articles were retrieved. Large scale studies or publications at more recent dates were selected. Data Synthesis. Broad spectrum antibiotics have been the main stay of treatment for bacterial keratitis but with the emergence of bacterial resistance; there is a need for newer antimicrobial agents and treatment methods. Fourth-generation fluoroquinolones and corneal collagen cross-linking are amongst the new treatments. In vitro studies and prospective clinical trials have shown that fourth-generation fluoroquinolones are better than the older generation fluoroquinolones and are as potent as combined fortified antibiotics against common pathogens that cause bacterial keratitis. Collagen cross-linking was shown to improve healing of infectious corneal ulcer in treatment-resistant cases or as an adjunct to antibiotics treatment. Conclusion. Fourth-generation fluoroquinolones are good alternatives to standard treatment of bacterial keratitis using combined fortified topical antibiotics. Collagen cross-linking may be considered in treatment-resistant infectious keratitis or as an adjunct to antibiotics therapy.en_US
dc.languageengen_US
dc.publisherHindawi Publishing Corporation. The Journal's web site is located at http://www.hindawi.com/journals/jopen_US
dc.relation.ispartofJournal of Ophthalmologyen_US
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleNew treatments for bacterial keratitisen_US
dc.typeArticleen_US
dc.identifier.emailWong, RLM: ray81@hku.hken_US
dc.identifier.emailGangwani, RA: gangwani@hku.hken_US
dc.identifier.emailLai, JSM: laism@hku.hken_US
dc.identifier.authorityWong, RLM=rp01394en_US
dc.identifier.authorityLai, JSM=rp00295en_US
dc.description.naturepublished_or_final_versionen_US
dc.identifier.doi10.1155/2012/831502en_US
dc.identifier.pmid22991650en_US
dc.identifier.pmcidPMC3444050en_US
dc.identifier.scopuseid_2-s2.0-84873852451-
dc.identifier.hkuros223881en_US
dc.identifier.volume2012, article no. 831502en_US
dc.identifier.isiWOS:000308754000001-
dc.publisher.placeUnited Statesen_US

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