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Article: Gonadotrophin ovulation induction is a successful treatment for World Health Organisation Group II anovulatory subfertility in women aged up to 40 and with body mass index up to 34

TitleGonadotrophin ovulation induction is a successful treatment for World Health Organisation Group II anovulatory subfertility in women aged up to 40 and with body mass index up to 34
Authors
Issue Date2010
PublisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/14647273.asp
Citation
Human Fertility, 2010, v. 13 n. 1, p. 35-40 How to Cite?
AbstractGonadotrophin-induced ovulation (GnOI) is generally an effective treatment when anti-estrogen therapy is unsuccessful. It remains uncertain how appropriate it is in older and obese women. We carried out an analysis of a GnOI programme between 2000 and 2008, including 514 treatment cycles in 140 women with World Health Organisation Group II anovulation. A low-dose step-up stimulation protocol using recombinant follicle stimulating hormone (FSH) (with natural intercourse) was used throughout in the treatment of women aged up to 40 years and with body mass index (BMI) up to 34 kg/m(2), with a rigorously-applied cancellation criterion. The livebirth rates in first stimulated cycle and cumulatively over six cycles (or until pregnancy) were 19.2% and 74.2%, respectively and the multiple livebirth rate was 2.5%. There was no significant relationship between age and BMI with pregnancy rates, although higher BMI was associated with higher threshold dose and longer duration of stimulation. Anti-estrogen resistant patients attained significantly higher cumulative ongoing pregnancy rates than those who were anti-estrogen responsive. These data demonstrate that judicious administration of gonadotrophins to women with WHO Group II anovulatory subfertility can result in a good pregnancy rate with low risk of multiple pregnancy in women aged up to 40 years and with BMI of up to 34 kg/m(2).
Persistent Identifierhttp://hdl.handle.net/10722/189562
ISSN
2015 Impact Factor: 0.988
2015 SCImago Journal Rankings: 0.525
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLi, RHWen_US
dc.contributor.authorVan Esch, Men_US
dc.contributor.authorDe Vries, Jen_US
dc.contributor.authorDuncan, WCen_US
dc.contributor.authorAnderson, RAen_US
dc.date.accessioned2013-09-17T14:46:52Z-
dc.date.available2013-09-17T14:46:52Z-
dc.date.issued2010en_US
dc.identifier.citationHuman Fertility, 2010, v. 13 n. 1, p. 35-40en_US
dc.identifier.issn1464-7273en_US
dc.identifier.urihttp://hdl.handle.net/10722/189562-
dc.description.abstractGonadotrophin-induced ovulation (GnOI) is generally an effective treatment when anti-estrogen therapy is unsuccessful. It remains uncertain how appropriate it is in older and obese women. We carried out an analysis of a GnOI programme between 2000 and 2008, including 514 treatment cycles in 140 women with World Health Organisation Group II anovulation. A low-dose step-up stimulation protocol using recombinant follicle stimulating hormone (FSH) (with natural intercourse) was used throughout in the treatment of women aged up to 40 years and with body mass index (BMI) up to 34 kg/m(2), with a rigorously-applied cancellation criterion. The livebirth rates in first stimulated cycle and cumulatively over six cycles (or until pregnancy) were 19.2% and 74.2%, respectively and the multiple livebirth rate was 2.5%. There was no significant relationship between age and BMI with pregnancy rates, although higher BMI was associated with higher threshold dose and longer duration of stimulation. Anti-estrogen resistant patients attained significantly higher cumulative ongoing pregnancy rates than those who were anti-estrogen responsive. These data demonstrate that judicious administration of gonadotrophins to women with WHO Group II anovulatory subfertility can result in a good pregnancy rate with low risk of multiple pregnancy in women aged up to 40 years and with BMI of up to 34 kg/m(2).en_US
dc.languageengen_US
dc.publisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/14647273.aspen_US
dc.relation.ispartofHuman Fertilityen_US
dc.rightsHuman Fertility. Copyright © Informa Healthcare.en_US
dc.subject.meshAnovulation - drug therapyen_US
dc.subject.meshFertilization in Vitroen_US
dc.subject.meshFollicle Stimulating Hormone, Human - therapeutic useen_US
dc.subject.meshInfertility, Female - drug therapyen_US
dc.subject.meshOvulation Induction - methodsen_US
dc.titleGonadotrophin ovulation induction is a successful treatment for World Health Organisation Group II anovulatory subfertility in women aged up to 40 and with body mass index up to 34en_US
dc.typeArticleen_US
dc.identifier.emailLi, RHW: raymondli@hku.hken_US
dc.identifier.authorityLi, RHW=rp01649en_US
dc.identifier.doi10.3109/14647270903490765en_US
dc.identifier.pmid20141336en_US
dc.identifier.hkuros222179en_US
dc.identifier.volume13en_US
dc.identifier.issue1en_US
dc.identifier.spage35en_US
dc.identifier.epage40en_US
dc.identifier.isiWOS:000291426100005-
dc.publisher.placeUnited Kingdomen_US

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