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Article: γδ-T cells: an unpolished sword in human anti-infection immunity

Titleγδ-T cells: an unpolished sword in human anti-infection immunity
Authors
Keywordshuman
γδ-T cells
infection
immunity
Issue Date2013
Citation
Cellular and Molecular Immunology, 2013, v. 10, p. 50-57 How to Cite?
Abstractγδ-T cells represent a small population of immune cells, but play an indispensable role in host defenses against exogenous pathogens, immune surveillance of endogenous pathogenesis and even homeostasis of the immune system. Activation and expansion of γδ-T cells are generally observed in diverse human infectious diseases and correlate with their progression and prognosis. γδ-T cells have both 'innate' and 'adaptive' characteristics in the immune response, and their anti-infection activities are mediated by multiple pathways that are under elaborate regulation by other immune components. In this review, we summarize the current state of the literature and the recent advancements in γδ-T cell-mediated immune responses against common human infectious pathogens. Although further investigation is needed to improve our understanding of the characteristics of different γδ-T cell subpopulations under specific conditions, γδ-T cell-based therapy has great potential for the treatment of infectious diseases. © 2013 CSI and USTC.
Persistent Identifierhttp://hdl.handle.net/10722/189313
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorZheng, Jen_US
dc.contributor.authorLiu, Yen_US
dc.contributor.authorLau, YLen_US
dc.contributor.authorTu, Wen_US
dc.date.accessioned2013-09-17T14:34:36Z-
dc.date.available2013-09-17T14:34:36Z-
dc.date.issued2013en_US
dc.identifier.citationCellular and Molecular Immunology, 2013, v. 10, p. 50-57en_US
dc.identifier.urihttp://hdl.handle.net/10722/189313-
dc.description.abstractγδ-T cells represent a small population of immune cells, but play an indispensable role in host defenses against exogenous pathogens, immune surveillance of endogenous pathogenesis and even homeostasis of the immune system. Activation and expansion of γδ-T cells are generally observed in diverse human infectious diseases and correlate with their progression and prognosis. γδ-T cells have both 'innate' and 'adaptive' characteristics in the immune response, and their anti-infection activities are mediated by multiple pathways that are under elaborate regulation by other immune components. In this review, we summarize the current state of the literature and the recent advancements in γδ-T cell-mediated immune responses against common human infectious pathogens. Although further investigation is needed to improve our understanding of the characteristics of different γδ-T cell subpopulations under specific conditions, γδ-T cell-based therapy has great potential for the treatment of infectious diseases. © 2013 CSI and USTC.-
dc.languageengen_US
dc.relation.ispartofCellular and Molecular Immunologyen_US
dc.subjecthuman-
dc.subjectγδ-T cells-
dc.subjectinfection-
dc.subjectimmunity-
dc.titleγδ-T cells: an unpolished sword in human anti-infection immunityen_US
dc.typeArticleen_US
dc.identifier.emailZheng, J: teddy629@hku.hken_US
dc.identifier.emailLiu, Y: yinpingl@hku.hken_US
dc.identifier.emailLau, YL: lauylung@hku.hken_US
dc.identifier.emailTu, W: wwtu@hku.hken_US
dc.identifier.authorityLiu, Y=rp00269en_US
dc.identifier.authorityLau, YL=rp00361en_US
dc.identifier.authorityTu, W=rp00416en_US
dc.identifier.doi10.1038/cmi.2012.43-
dc.identifier.pmid23064104-
dc.identifier.scopuseid_2-s2.0-84872177557-
dc.identifier.hkuros223373en_US
dc.identifier.hkuros225531-
dc.identifier.volume10en_US
dc.identifier.spage50en_US
dc.identifier.epage57en_US
dc.identifier.isiWOS:000313207800011-

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