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Article: A cyanine based fluorophore emitting both single photon near-infrared fluorescence and two-photon deep red fluorescence in aqueous solution

TitleA cyanine based fluorophore emitting both single photon near-infrared fluorescence and two-photon deep red fluorescence in aqueous solution
Authors
Issue Date2012
PublisherRoyal Society of Chemistry. The Journal's web site is located at http://www.rsc.org/obc
Citation
Organic & Biomolecular Chemistry, 2012, v. 10 n. 28, p. 5366-70 How to Cite?
AbstractOptical imaging provides an indispensable way to locate tumors in their early stages with high sensitivity and signal to background ratio. A heptamethine cyanine based fluorophore that emits both single photon near-infrared fluorescence and two-photon deep red fluorescence under physiological conditions was developed. Linear and nonlinear photophysical properties of this fluorophore were investigated and it demonstrated the capability to label lysosomes in cancer cells. The advantages of this fluorophore, including tolerable cytotoxicity, high fluorescence quantum yield, and the ability to emit both near-infrared single photon fluorescence and deep red two photon fluorescence in aqueous solution, give it potential to be used in intra-operatively optical image-guided tumor excision followed by two-photon fluorescence microscopy biopsy analysis after a single administration.
Persistent Identifierhttp://hdl.handle.net/10722/188890
ISSN
2015 Impact Factor: 3.559
2015 SCImago Journal Rankings: 1.464
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWang, Len_US
dc.contributor.authorJin, Jen_US
dc.contributor.authorChen, XSen_US
dc.contributor.authorFan, HHen_US
dc.contributor.authorLi, BKFen_US
dc.contributor.authorCheah, KWen_US
dc.contributor.authorDing, Nen_US
dc.contributor.authorJu, SHen_US
dc.contributor.authorWong, WTen_US
dc.contributor.authorLi, Cen_US
dc.date.accessioned2013-09-17T14:19:50Z-
dc.date.available2013-09-17T14:19:50Z-
dc.date.issued2012en_US
dc.identifier.citationOrganic & Biomolecular Chemistry, 2012, v. 10 n. 28, p. 5366-70en_US
dc.identifier.issn1477-0520en_US
dc.identifier.urihttp://hdl.handle.net/10722/188890-
dc.description.abstractOptical imaging provides an indispensable way to locate tumors in their early stages with high sensitivity and signal to background ratio. A heptamethine cyanine based fluorophore that emits both single photon near-infrared fluorescence and two-photon deep red fluorescence under physiological conditions was developed. Linear and nonlinear photophysical properties of this fluorophore were investigated and it demonstrated the capability to label lysosomes in cancer cells. The advantages of this fluorophore, including tolerable cytotoxicity, high fluorescence quantum yield, and the ability to emit both near-infrared single photon fluorescence and deep red two photon fluorescence in aqueous solution, give it potential to be used in intra-operatively optical image-guided tumor excision followed by two-photon fluorescence microscopy biopsy analysis after a single administration.en_US
dc.languageengen_US
dc.publisherRoyal Society of Chemistry. The Journal's web site is located at http://www.rsc.org/obcen_US
dc.relation.ispartofOrganic & Biomolecular Chemistryen_US
dc.subject.meshCarbocyanines - analysis - chemical synthesis - chemistryen_US
dc.subject.meshCell Survivalen_US
dc.subject.meshFluorescent Dyes - analysis - chemical synthesis - chemistryen_US
dc.subject.meshMicroscopy, Fluorescence - methodsen_US
dc.subject.meshNeoplasms - diagnosisen_US
dc.titleA cyanine based fluorophore emitting both single photon near-infrared fluorescence and two-photon deep red fluorescence in aqueous solutionen_US
dc.typeArticleen_US
dc.identifier.doi10.1039/c2ob25619cen_US
dc.identifier.pmid22710825en_US
dc.identifier.hkuros222446en_US
dc.identifier.volume10en_US
dc.identifier.issue28en_US
dc.identifier.spage5366en_US
dc.identifier.epage70en_US
dc.identifier.isiWOS:000305764600008-
dc.publisher.placeUnited Kingdomen_US

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