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Article: Behavioral Stress fails to Accelerate the Onset and Progression of Plaque Pathology in the Brain of a Mouse Model of Alzheimer's Disease

TitleBehavioral Stress fails to Accelerate the Onset and Progression of Plaque Pathology in the Brain of a Mouse Model of Alzheimer's Disease
Authors
Issue Date2013
PublisherPublic Library of Science. The Journal's web site is located at http://www.plosone.org/home.action
Citation
PLoS One, 2013, v. 8 n. 1, p. e53480 How to Cite?
AbstractConflicting findings exist regarding the link between environmental factors and development of Alzheimer's disease (AD) in a variety of transgenic mouse models of AD. In the present study, we investigated the effect of behavioral stress on the onset and progression of Abeta pathology in the brains of TgCRND8 mice, a transgenic mouse model of AD. One group of TgCRND8 mice was subjected to restraint stress starting at 1 month of age until they were 3 months old, while restraint stress in the second group started at 4 months of age until they were 6 months old. After 2 months of treatment, no differences in the soluble, formic acid extracted, or histologically detected Abeta deposition in the cortical and hippocampal levels were found between non-stressed and stressed mice. These results showed that restraint stress alone failed to aggravate amyloid pathology when initiated either before or after the age of amyloid plaque deposition in TgCRND8 mice, suggesting that if stress aggravated AD phenotype, it may not be via an amyloid-related mechanism in the TgCRND8 mice. These findings are indicative that plaque load per se may not be used as a significant criterion for evaluating the effect of stress on AD patients.
Persistent Identifierhttp://hdl.handle.net/10722/188847
ISSN
2015 Impact Factor: 3.057
2015 SCImago Journal Rankings: 1.395
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorYuan, QJen_US
dc.contributor.authorSu, HXen_US
dc.contributor.authorChau, WHen_US
dc.contributor.authorNg, GCTen_US
dc.contributor.authorHuang, JDen_US
dc.contributor.authorWu, Wen_US
dc.contributor.authorLin, ZXen_US
dc.date.accessioned2013-09-17T14:17:34Z-
dc.date.available2013-09-17T14:17:34Z-
dc.date.issued2013en_US
dc.identifier.citationPLoS One, 2013, v. 8 n. 1, p. e53480en_US
dc.identifier.issn1932-6203en_US
dc.identifier.urihttp://hdl.handle.net/10722/188847-
dc.description.abstractConflicting findings exist regarding the link between environmental factors and development of Alzheimer's disease (AD) in a variety of transgenic mouse models of AD. In the present study, we investigated the effect of behavioral stress on the onset and progression of Abeta pathology in the brains of TgCRND8 mice, a transgenic mouse model of AD. One group of TgCRND8 mice was subjected to restraint stress starting at 1 month of age until they were 3 months old, while restraint stress in the second group started at 4 months of age until they were 6 months old. After 2 months of treatment, no differences in the soluble, formic acid extracted, or histologically detected Abeta deposition in the cortical and hippocampal levels were found between non-stressed and stressed mice. These results showed that restraint stress alone failed to aggravate amyloid pathology when initiated either before or after the age of amyloid plaque deposition in TgCRND8 mice, suggesting that if stress aggravated AD phenotype, it may not be via an amyloid-related mechanism in the TgCRND8 mice. These findings are indicative that plaque load per se may not be used as a significant criterion for evaluating the effect of stress on AD patients.en_US
dc.languageengen_US
dc.publisherPublic Library of Science. The Journal's web site is located at http://www.plosone.org/home.actionen_US
dc.relation.ispartofPLoS Oneen_US
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshAlzheimer Disease - blood - complications - pathology - psychologyen_US
dc.subject.meshBehavior, Animalen_US
dc.subject.meshBrain - metabolism - pathologyen_US
dc.subject.meshPlaque, Amyloid - blood - complications - pathologyen_US
dc.subject.meshStress, Psychological - blood - complications - pathologyen_US
dc.titleBehavioral Stress fails to Accelerate the Onset and Progression of Plaque Pathology in the Brain of a Mouse Model of Alzheimer's Diseaseen_US
dc.typeArticleen_US
dc.identifier.emailNg, GCT: gordng@hku.hken_US
dc.identifier.emailHuang, JD: jdhuang@hku.hken_US
dc.identifier.emailWu, W: wtwu@hkucc.hku.hken_US
dc.identifier.authorityHuang, JD=rp00451en_US
dc.identifier.authorityWu, W=rp00419en_US
dc.description.naturepublished_or_final_versionen_US
dc.identifier.doi10.1371/journal.pone.0053480en_US
dc.identifier.pmid23326437en_US
dc.identifier.pmcidPMC3543430en_US
dc.identifier.hkuros222730en_US
dc.identifier.volume8en_US
dc.identifier.issue1en_US
dc.identifier.spagee53480en_US
dc.identifier.epagee53480en_US
dc.identifier.isiWOS:000314705800047-
dc.publisher.placeUnited Statesen_US

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