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Article: Flipping lipids: Why an' what's the reason for?

TitleFlipping lipids: Why an' what's the reason for?
Authors
Issue Date2009
PublisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/journals/acbcct/index.html
Citation
Acs Chemical Biology, 2009, v. 4 n. 11, p. 895-909 How to Cite?
AbstractThe biosynthesis of glycoconjugates such as N-glycoproteins and GPI-anchored proteins in eukaryotes and cell wall peptidoglycan and lipopolysaccharide in bacteria requires lipid intermediates to be flipped rapidly across the endoplasmic reticulum or bacterial cytoplasmic membrane (so-called biogenic membranes). Rapid flipping is also required to normalize the number of glycerophospholipids in the two leaflets of the bilayer as the membrane expands in a growing cell. Although lipids diffuse rapidly in the plane of the membrane, the intrinsic rate at which they flip across membranes is very low. Biogenic membranes possess dedicated lipid transporters or flippases to increase flipping to a physiologically sufficient rate. The flippases are "ATP-independent" and facilitate "downhill" transport. Most predicted biogenic membrane flippases have not been identified at the molecular level, and the few flippases that have been identified by genetic approaches have not been biochemically validated. Here we summarize recent progress on this fundamental topic and speculate on the mechanism(s) by which biogenic membrane flippases facilitate transbilayer lipid movement. © 2009 American Chemical Society.
Persistent Identifierhttp://hdl.handle.net/10722/188680
ISSN
2015 Impact Factor: 5.09
2015 SCImago Journal Rankings: 2.863
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorSanyal, Sen_US
dc.contributor.authorMenon, AKen_US
dc.date.accessioned2013-09-03T04:12:44Z-
dc.date.available2013-09-03T04:12:44Z-
dc.date.issued2009en_US
dc.identifier.citationAcs Chemical Biology, 2009, v. 4 n. 11, p. 895-909en_US
dc.identifier.issn1554-8929en_US
dc.identifier.urihttp://hdl.handle.net/10722/188680-
dc.description.abstractThe biosynthesis of glycoconjugates such as N-glycoproteins and GPI-anchored proteins in eukaryotes and cell wall peptidoglycan and lipopolysaccharide in bacteria requires lipid intermediates to be flipped rapidly across the endoplasmic reticulum or bacterial cytoplasmic membrane (so-called biogenic membranes). Rapid flipping is also required to normalize the number of glycerophospholipids in the two leaflets of the bilayer as the membrane expands in a growing cell. Although lipids diffuse rapidly in the plane of the membrane, the intrinsic rate at which they flip across membranes is very low. Biogenic membranes possess dedicated lipid transporters or flippases to increase flipping to a physiologically sufficient rate. The flippases are "ATP-independent" and facilitate "downhill" transport. Most predicted biogenic membrane flippases have not been identified at the molecular level, and the few flippases that have been identified by genetic approaches have not been biochemically validated. Here we summarize recent progress on this fundamental topic and speculate on the mechanism(s) by which biogenic membrane flippases facilitate transbilayer lipid movement. © 2009 American Chemical Society.en_US
dc.languageengen_US
dc.publisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/journals/acbcct/index.htmlen_US
dc.relation.ispartofACS Chemical Biologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBiological Transporten_US
dc.subject.meshCell Membrane - Metabolismen_US
dc.subject.meshCell Wall - Metabolismen_US
dc.subject.meshLipid Metabolismen_US
dc.subject.meshLipids - Chemistryen_US
dc.titleFlipping lipids: Why an' what's the reason for?en_US
dc.typeArticleen_US
dc.identifier.emailSanyal, S: sumana@wi.mit.eduen_US
dc.identifier.authoritySanyal, S=rp01794en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1021/cb900163den_US
dc.identifier.pmid19689162-
dc.identifier.scopuseid_2-s2.0-73449119238en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-73449119238&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume4en_US
dc.identifier.issue11en_US
dc.identifier.spage895en_US
dc.identifier.epage909en_US
dc.identifier.isiWOS:000271896000003-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridSanyal, S=16069600000en_US
dc.identifier.scopusauthoridMenon, AK=7202324192en_US

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