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- Publisher Website: 10.1021/cb900163d
- Scopus: eid_2-s2.0-73449119238
- PMID: 19689162
- WOS: WOS:000271896000003
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Article: Flipping lipids: Why an' what's the reason for?
Title | Flipping lipids: Why an' what's the reason for? |
---|---|
Authors | |
Issue Date | 2009 |
Publisher | American Chemical Society. The Journal's web site is located at http://pubs.acs.org/journals/acbcct/index.html |
Citation | Acs Chemical Biology, 2009, v. 4 n. 11, p. 895-909 How to Cite? |
Abstract | The biosynthesis of glycoconjugates such as N-glycoproteins and GPI-anchored proteins in eukaryotes and cell wall peptidoglycan and lipopolysaccharide in bacteria requires lipid intermediates to be flipped rapidly across the endoplasmic reticulum or bacterial cytoplasmic membrane (so-called biogenic membranes). Rapid flipping is also required to normalize the number of glycerophospholipids in the two leaflets of the bilayer as the membrane expands in a growing cell. Although lipids diffuse rapidly in the plane of the membrane, the intrinsic rate at which they flip across membranes is very low. Biogenic membranes possess dedicated lipid transporters or flippases to increase flipping to a physiologically sufficient rate. The flippases are "ATP-independent" and facilitate "downhill" transport. Most predicted biogenic membrane flippases have not been identified at the molecular level, and the few flippases that have been identified by genetic approaches have not been biochemically validated. Here we summarize recent progress on this fundamental topic and speculate on the mechanism(s) by which biogenic membrane flippases facilitate transbilayer lipid movement. © 2009 American Chemical Society. |
Persistent Identifier | http://hdl.handle.net/10722/188680 |
ISSN | 2023 Impact Factor: 3.5 2023 SCImago Journal Rankings: 1.344 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Sanyal, S | en_US |
dc.contributor.author | Menon, AK | en_US |
dc.date.accessioned | 2013-09-03T04:12:44Z | - |
dc.date.available | 2013-09-03T04:12:44Z | - |
dc.date.issued | 2009 | en_US |
dc.identifier.citation | Acs Chemical Biology, 2009, v. 4 n. 11, p. 895-909 | en_US |
dc.identifier.issn | 1554-8929 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/188680 | - |
dc.description.abstract | The biosynthesis of glycoconjugates such as N-glycoproteins and GPI-anchored proteins in eukaryotes and cell wall peptidoglycan and lipopolysaccharide in bacteria requires lipid intermediates to be flipped rapidly across the endoplasmic reticulum or bacterial cytoplasmic membrane (so-called biogenic membranes). Rapid flipping is also required to normalize the number of glycerophospholipids in the two leaflets of the bilayer as the membrane expands in a growing cell. Although lipids diffuse rapidly in the plane of the membrane, the intrinsic rate at which they flip across membranes is very low. Biogenic membranes possess dedicated lipid transporters or flippases to increase flipping to a physiologically sufficient rate. The flippases are "ATP-independent" and facilitate "downhill" transport. Most predicted biogenic membrane flippases have not been identified at the molecular level, and the few flippases that have been identified by genetic approaches have not been biochemically validated. Here we summarize recent progress on this fundamental topic and speculate on the mechanism(s) by which biogenic membrane flippases facilitate transbilayer lipid movement. © 2009 American Chemical Society. | en_US |
dc.language | eng | en_US |
dc.publisher | American Chemical Society. The Journal's web site is located at http://pubs.acs.org/journals/acbcct/index.html | en_US |
dc.relation.ispartof | ACS Chemical Biology | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Biological Transport | en_US |
dc.subject.mesh | Cell Membrane - Metabolism | en_US |
dc.subject.mesh | Cell Wall - Metabolism | en_US |
dc.subject.mesh | Lipid Metabolism | en_US |
dc.subject.mesh | Lipids - Chemistry | en_US |
dc.title | Flipping lipids: Why an' what's the reason for? | en_US |
dc.type | Article | en_US |
dc.identifier.email | Sanyal, S: sumana@wi.mit.edu | en_US |
dc.identifier.authority | Sanyal, S=rp01794 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1021/cb900163d | en_US |
dc.identifier.pmid | 19689162 | - |
dc.identifier.scopus | eid_2-s2.0-73449119238 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-73449119238&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 4 | en_US |
dc.identifier.issue | 11 | en_US |
dc.identifier.spage | 895 | en_US |
dc.identifier.epage | 909 | en_US |
dc.identifier.isi | WOS:000271896000003 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Sanyal, S=16069600000 | en_US |
dc.identifier.scopusauthorid | Menon, AK=7202324192 | en_US |
dc.identifier.issnl | 1554-8929 | - |