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Article: Characterizing acupuncture de Qi in mild cognitive impairment: Relations with small-world efficiency of functional brain networks

TitleCharacterizing acupuncture de Qi in mild cognitive impairment: Relations with small-world efficiency of functional brain networks
Authors
Issue Date2013
PublisherHindawi Publishing Corporation. The Journal's web site is located at http://www.hindawi.com/journals/ecam/
Citation
Evidence-Based Complementary And Alternative Medicine, 2013, v. 2013 How to Cite?
AbstractAs an intermediate state between normal aging and dementia, mild cognitive impairment (MCI) became a hot topic and early treatments can improve disease prognosis. Acupuncture is shown to have possible effect in improving its cognitive defect. However, the underlying neural mechanism of acupuncture and relations between De Qi and different needling depths are still elusive. The present study aimed to explore how acupuncture can exert effect on the reorganization of MCI and to what extent needling depths, associating with De Qi sensations, can influence the acupuncture effects for MCI treatment. Our results presented that MCI patients exhibited losses of small-world attributes indicated by longer characteristic path lengths and larger clustering coefficients, compared with healthy controls. In addition, acupuncture with deep needling can induce much stronger and a wide range of De Qi sensations both in intensity and prevalence. Acupuncture with deep needling showed modulatory effect to compensate the losses of small-world attributes existed in MCI patients while acupuncture with superficial needling did not. Furthermore, acupuncture with deep needling enhanced the nodal centrality primarily in the abnormal regions of MCI including the hippocampus, postcentral cortex as well as anterior cingulate cortex. This study provides evidence to understand neural mechanism underlying acupuncture and the key role of De Qi for MCI treatment. © 2013 Lijun Bai et al.
Persistent Identifierhttp://hdl.handle.net/10722/188670
ISSN
2015 Impact Factor: 1.931
2015 SCImago Journal Rankings: 0.615
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorBai, Len_US
dc.contributor.authorZhang, Men_US
dc.contributor.authorChen, Sen_US
dc.contributor.authorAi, Len_US
dc.contributor.authorXu, Men_US
dc.contributor.authorWang, Den_US
dc.contributor.authorWang, Fen_US
dc.contributor.authorLiu, Len_US
dc.contributor.authorWang, Fen_US
dc.contributor.authorLao, Len_US
dc.date.accessioned2013-09-03T04:11:00Z-
dc.date.available2013-09-03T04:11:00Z-
dc.date.issued2013en_US
dc.identifier.citationEvidence-Based Complementary And Alternative Medicine, 2013, v. 2013en_US
dc.identifier.issn1741-427Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/188670-
dc.description.abstractAs an intermediate state between normal aging and dementia, mild cognitive impairment (MCI) became a hot topic and early treatments can improve disease prognosis. Acupuncture is shown to have possible effect in improving its cognitive defect. However, the underlying neural mechanism of acupuncture and relations between De Qi and different needling depths are still elusive. The present study aimed to explore how acupuncture can exert effect on the reorganization of MCI and to what extent needling depths, associating with De Qi sensations, can influence the acupuncture effects for MCI treatment. Our results presented that MCI patients exhibited losses of small-world attributes indicated by longer characteristic path lengths and larger clustering coefficients, compared with healthy controls. In addition, acupuncture with deep needling can induce much stronger and a wide range of De Qi sensations both in intensity and prevalence. Acupuncture with deep needling showed modulatory effect to compensate the losses of small-world attributes existed in MCI patients while acupuncture with superficial needling did not. Furthermore, acupuncture with deep needling enhanced the nodal centrality primarily in the abnormal regions of MCI including the hippocampus, postcentral cortex as well as anterior cingulate cortex. This study provides evidence to understand neural mechanism underlying acupuncture and the key role of De Qi for MCI treatment. © 2013 Lijun Bai et al.en_US
dc.languageengen_US
dc.publisherHindawi Publishing Corporation. The Journal's web site is located at http://www.hindawi.com/journals/ecam/en_US
dc.relation.ispartofEvidence-based Complementary and Alternative Medicineen_US
dc.titleCharacterizing acupuncture de Qi in mild cognitive impairment: Relations with small-world efficiency of functional brain networksen_US
dc.typeArticleen_US
dc.identifier.emailLao, L: lxlao1@hku.hken_US
dc.identifier.authorityLao, L=rp01784en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1155/2013/304804en_US
dc.identifier.scopuseid_2-s2.0-84880877950en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84880877950&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume2013en_US
dc.identifier.isiWOS:000322228900001-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridBai, L=23388423400en_US
dc.identifier.scopusauthoridZhang, M=35304112800en_US
dc.identifier.scopusauthoridChen, S=26643435600en_US
dc.identifier.scopusauthoridAi, L=16834591400en_US
dc.identifier.scopusauthoridXu, M=55806877100en_US
dc.identifier.scopusauthoridWang, D=55807844800en_US
dc.identifier.scopusauthoridWang, F=55569207200en_US
dc.identifier.scopusauthoridLiu, L=55535347100en_US
dc.identifier.scopusauthoridWang, F=55740547500en_US
dc.identifier.scopusauthoridLao, L=7005681883en_US

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