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Article: Anti-inflammatory activities of a Chinese herbal formula IBS-20 in vitro and in vivo

TitleAnti-inflammatory activities of a Chinese herbal formula IBS-20 in vitro and in vivo
Authors
Issue Date2012
PublisherHindawi Publishing Corporation. The Journal's web site is located at http://www.hindawi.com/journals/ecam/
Citation
Evidence-Based Complementary And Alternative Medicine, 2012, v. 2012 How to Cite?
AbstractIrritable bowel syndrome (IBS) is a functional bowel disorder and the etiology is not well understood. Currently there is no cure for IBS and no existing medication induces symptom relief in all patients. IBS-20 is a 20-herb Chinese medicinal formula that offers beneficial effects in patients with IBS; however, the underlying mechanisms are largely unknown. This study showed that IBS-20 potently inhibited LPS- or IFN-stimulated expression of pro-inflammatory cytokines, as well as classically activated macrophage marker nitric oxide synthase 2. Similarly, IBS-20 or the component herb Coptis chinensis decreased LPS-stimulated pro-inflammatory cytokine secretion from JAWS II dendritic cells. IBS-20 or the component herbs also blocked or attenuated the IFN-induced drop in transepithelial electric resistance, an index of permeability, in fully differentiated Caco-2 monolayer. Finally, the up-regulation of key inflammatory cytokines in inflamed colon from TNBS-treated mice was suppressed significantly by orally administrated IBS-20, including IFN and IL-12p40. These data indicate that the anti-inflammatory activities of IBS-20 may contribute to the beneficial effects of the herbal extract in patients with IBS, providing a potential mechanism of action for IBS-20. In addition, IBS-20 may be a potential therapeutic agent against other Th1-dominant gut pathologies such as inflammatory bowel disease. Copyright 2012 Zhonghan Yang et al.
Persistent Identifierhttp://hdl.handle.net/10722/188652
ISSN
2015 Impact Factor: 1.931
2015 SCImago Journal Rankings: 0.615
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorYang, Zen_US
dc.contributor.authorGrinchuk, Ven_US
dc.contributor.authorIp, SPen_US
dc.contributor.authorChe, CTen_US
dc.contributor.authorFong, HHSen_US
dc.contributor.authorLao, Len_US
dc.contributor.authorWu, JCen_US
dc.contributor.authorSung, JJen_US
dc.contributor.authorBerman, Ben_US
dc.contributor.authorSheaDonohue, Ten_US
dc.contributor.authorZhao, Aen_US
dc.date.accessioned2013-09-03T04:10:52Z-
dc.date.available2013-09-03T04:10:52Z-
dc.date.issued2012en_US
dc.identifier.citationEvidence-Based Complementary And Alternative Medicine, 2012, v. 2012en_US
dc.identifier.issn1741-427Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/188652-
dc.description.abstractIrritable bowel syndrome (IBS) is a functional bowel disorder and the etiology is not well understood. Currently there is no cure for IBS and no existing medication induces symptom relief in all patients. IBS-20 is a 20-herb Chinese medicinal formula that offers beneficial effects in patients with IBS; however, the underlying mechanisms are largely unknown. This study showed that IBS-20 potently inhibited LPS- or IFN-stimulated expression of pro-inflammatory cytokines, as well as classically activated macrophage marker nitric oxide synthase 2. Similarly, IBS-20 or the component herb Coptis chinensis decreased LPS-stimulated pro-inflammatory cytokine secretion from JAWS II dendritic cells. IBS-20 or the component herbs also blocked or attenuated the IFN-induced drop in transepithelial electric resistance, an index of permeability, in fully differentiated Caco-2 monolayer. Finally, the up-regulation of key inflammatory cytokines in inflamed colon from TNBS-treated mice was suppressed significantly by orally administrated IBS-20, including IFN and IL-12p40. These data indicate that the anti-inflammatory activities of IBS-20 may contribute to the beneficial effects of the herbal extract in patients with IBS, providing a potential mechanism of action for IBS-20. In addition, IBS-20 may be a potential therapeutic agent against other Th1-dominant gut pathologies such as inflammatory bowel disease. Copyright 2012 Zhonghan Yang et al.en_US
dc.languageengen_US
dc.publisherHindawi Publishing Corporation. The Journal's web site is located at http://www.hindawi.com/journals/ecam/en_US
dc.relation.ispartofEvidence-based Complementary and Alternative Medicineen_US
dc.titleAnti-inflammatory activities of a Chinese herbal formula IBS-20 in vitro and in vivoen_US
dc.typeArticleen_US
dc.identifier.emailLao, L: lxlao1@hku.hken_US
dc.identifier.authorityLao, L=rp01784en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1155/2012/491496en_US
dc.identifier.scopuseid_2-s2.0-84863270697en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84863270697&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume2012en_US
dc.identifier.isiWOS:000301367100001-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridYang, Z=9338161300en_US
dc.identifier.scopusauthoridGrinchuk, V=37031063600en_US
dc.identifier.scopusauthoridIp, SP=7006626448en_US
dc.identifier.scopusauthoridChe, CT=7102442768en_US
dc.identifier.scopusauthoridFong, HHS=34569199300en_US
dc.identifier.scopusauthoridLao, L=7005681883en_US
dc.identifier.scopusauthoridWu, JC=7409253910en_US
dc.identifier.scopusauthoridSung, JJ=35405352400en_US
dc.identifier.scopusauthoridBerman, B=35458606800en_US
dc.identifier.scopusauthoridSheaDonohue, T=7003754030en_US
dc.identifier.scopusauthoridZhao, A=7102542644en_US

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