File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Schisandra chinensis reverses visceral hypersensitivity in a neonatal-maternal separated rat model

TitleSchisandra chinensis reverses visceral hypersensitivity in a neonatal-maternal separated rat model
Authors
Keywords5-Ht
Neonatal Maternal Separation
Schisandra Chinensis
Visceral Hypersensitivity
Issue Date2012
PublisherUrban und Fischer Verlag. The Journal's web site is located at http://www.elsevier.com/locate/phytomed
Citation
Phytomedicine, 2012, v. 19 n. 5, p. 402-408 How to Cite?
AbstractVisceral hypersensitivity is an important characteristic feature of functional gastrointestinal disorders, such as irritable bowel syndrome (IBS). This study evaluated the effect of Schisandra chinensis on visceral hyperalgesia induced by neonatal maternal separation (NMS) in an IBS rat model. The visceromotor responses to colorectal balloon distension (CRD) were measured by abdominal withdrawal reflex (AWR) and electromyographic (EMG) activities. NMS control rats (receiving vehicle) underwent aggravated visceral pain in response to CRD as compared to normal rats, evidenced by the reduced pain threshold, enhanced AWR scores and EMG responses. Treatment with a 70% ethanol extract of S. chinensis (0.3 g/kg and 1.5 g/kg/day) for 7 days resulted in an increase in the pain threshold (NMS control: 19.1 ± 1.0 mmHg vs low-dose: 24.8 ± 1.3 mmHg and high-dose: 25.2 ± 1.8 mmHg, p < 0.01), and abolished the elevated AWR and EMG responses to CRD in NMS rats (AUC values of EMG response curve were: 1952 ± 202 in NMS control group vs 1074 ± 90 in low-dose group and 1145 ± 92 in high-dose group, p < 0.001), indicating that S. chinensis could reverse the visceral hypersensitivity induced by early-life stress event. The result of ELSA measurement shows that the elevated serotonin (5-HT) level in the distal colon of NMS rats returned to normal level after treatment with S. chinensis. Moreover, the increase in pain threshold in rats treated with S. chinensis was associated with a decline of the mRNA level of 5-HT 3 receptor in the distal colon. All available results demonstrate that S. chinensis can reverse visceral hypersensitivity induced by neonatal-maternal separation, and the effect may be mediated through colonic 5-HT pathway in the rat. © 2011 Elsevier GmbH. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/188644
ISSN
2015 Impact Factor: 2.937
2015 SCImago Journal Rankings: 1.013
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorYang, JMen_US
dc.contributor.authorXian, YFen_US
dc.contributor.authorIp, PSPen_US
dc.contributor.authorWu, JCYen_US
dc.contributor.authorLao, Len_US
dc.contributor.authorFong, HHSen_US
dc.contributor.authorSung, JJYen_US
dc.contributor.authorBerman, Ben_US
dc.contributor.authorYeung, JHKen_US
dc.contributor.authorChe, CTen_US
dc.date.accessioned2013-09-03T04:10:47Z-
dc.date.available2013-09-03T04:10:47Z-
dc.date.issued2012en_US
dc.identifier.citationPhytomedicine, 2012, v. 19 n. 5, p. 402-408en_US
dc.identifier.issn0944-7113en_US
dc.identifier.urihttp://hdl.handle.net/10722/188644-
dc.description.abstractVisceral hypersensitivity is an important characteristic feature of functional gastrointestinal disorders, such as irritable bowel syndrome (IBS). This study evaluated the effect of Schisandra chinensis on visceral hyperalgesia induced by neonatal maternal separation (NMS) in an IBS rat model. The visceromotor responses to colorectal balloon distension (CRD) were measured by abdominal withdrawal reflex (AWR) and electromyographic (EMG) activities. NMS control rats (receiving vehicle) underwent aggravated visceral pain in response to CRD as compared to normal rats, evidenced by the reduced pain threshold, enhanced AWR scores and EMG responses. Treatment with a 70% ethanol extract of S. chinensis (0.3 g/kg and 1.5 g/kg/day) for 7 days resulted in an increase in the pain threshold (NMS control: 19.1 ± 1.0 mmHg vs low-dose: 24.8 ± 1.3 mmHg and high-dose: 25.2 ± 1.8 mmHg, p < 0.01), and abolished the elevated AWR and EMG responses to CRD in NMS rats (AUC values of EMG response curve were: 1952 ± 202 in NMS control group vs 1074 ± 90 in low-dose group and 1145 ± 92 in high-dose group, p < 0.001), indicating that S. chinensis could reverse the visceral hypersensitivity induced by early-life stress event. The result of ELSA measurement shows that the elevated serotonin (5-HT) level in the distal colon of NMS rats returned to normal level after treatment with S. chinensis. Moreover, the increase in pain threshold in rats treated with S. chinensis was associated with a decline of the mRNA level of 5-HT 3 receptor in the distal colon. All available results demonstrate that S. chinensis can reverse visceral hypersensitivity induced by neonatal-maternal separation, and the effect may be mediated through colonic 5-HT pathway in the rat. © 2011 Elsevier GmbH. All rights reserved.en_US
dc.languageengen_US
dc.publisherUrban und Fischer Verlag. The Journal's web site is located at http://www.elsevier.com/locate/phytomeden_US
dc.relation.ispartofPhytomedicineen_US
dc.subject5-Hten_US
dc.subjectNeonatal Maternal Separationen_US
dc.subjectSchisandra Chinensisen_US
dc.subjectVisceral Hypersensitivityen_US
dc.titleSchisandra chinensis reverses visceral hypersensitivity in a neonatal-maternal separated rat modelen_US
dc.typeArticleen_US
dc.identifier.emailLao, L: lxlao1@hku.hken_US
dc.identifier.authorityLao, L=rp01784en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.phymed.2011.11.013en_US
dc.identifier.pmid22230486-
dc.identifier.scopuseid_2-s2.0-84858080036en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84858080036&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume19en_US
dc.identifier.issue5en_US
dc.identifier.spage402en_US
dc.identifier.epage408en_US
dc.identifier.isiWOS:000303036000004-
dc.publisher.placeGermanyen_US
dc.identifier.scopusauthoridYang, JM=37103200400en_US
dc.identifier.scopusauthoridXian, YF=35103878000en_US
dc.identifier.scopusauthoridIp, PSP=36104141500en_US
dc.identifier.scopusauthoridWu, JCY=34870755800en_US
dc.identifier.scopusauthoridLao, L=7005681883en_US
dc.identifier.scopusauthoridFong, HHS=34569199300en_US
dc.identifier.scopusauthoridSung, JJY=35405352400en_US
dc.identifier.scopusauthoridBerman, B=35458606800en_US
dc.identifier.scopusauthoridYeung, JHK=7006803824en_US
dc.identifier.scopusauthoridChe, CT=7102442768en_US

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats