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Article: Evaluating traditional Chinese medicine using modern clinical trial design and statistical methodology: Application to a randomized controlled acupuncture trial

TitleEvaluating traditional Chinese medicine using modern clinical trial design and statistical methodology: Application to a randomized controlled acupuncture trial
Authors
Issue Date2012
PublisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0277-6715/
Citation
Statistics In Medicine, 2012, v. 31 n. 7, p. 619-627 How to Cite?
AbstractTraditional Chinese medicine (TCM), used in China and other Asian counties for thousands of years, is increasingly utilized in Western countries. However, due to inherent differences in how Western medicine and this ancient modality are practiced, employing the so-called Western medicine-based gold standard research methods to evaluate TCM is challenging. This paper is a discussion of the obstacles inherent in the design and statistical analysis of clinical trials of TCM. It is based on our experience in designing and conducting a randomized controlled clinical trial of acupuncture for post-operative dental pain control in which acupuncture was shown to be statistically and significantly better than placebo in lengthening the median survival time to rescue drug. We demonstrate here that PH assumptions in the common Cox model did not hold in that trial and that TCM trials warrant more thoughtful modeling and more sophisticated models of statistical analysis. TCM study design entails all the challenges encountered in trials of drugs, devices, and surgical procedures in the Western medicine. We present possible solutions to some but leave many issues unresolved. © 2011 John Wiley & Sons, Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/188643
ISSN
2015 Impact Factor: 1.533
2015 SCImago Journal Rankings: 1.811
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLao, Len_US
dc.contributor.authorHuang, Yen_US
dc.contributor.authorFeng, Cen_US
dc.contributor.authorBerman, BMen_US
dc.contributor.authorTan, MTen_US
dc.date.accessioned2013-09-03T04:10:46Z-
dc.date.available2013-09-03T04:10:46Z-
dc.date.issued2012en_US
dc.identifier.citationStatistics In Medicine, 2012, v. 31 n. 7, p. 619-627en_US
dc.identifier.issn0277-6715en_US
dc.identifier.urihttp://hdl.handle.net/10722/188643-
dc.description.abstractTraditional Chinese medicine (TCM), used in China and other Asian counties for thousands of years, is increasingly utilized in Western countries. However, due to inherent differences in how Western medicine and this ancient modality are practiced, employing the so-called Western medicine-based gold standard research methods to evaluate TCM is challenging. This paper is a discussion of the obstacles inherent in the design and statistical analysis of clinical trials of TCM. It is based on our experience in designing and conducting a randomized controlled clinical trial of acupuncture for post-operative dental pain control in which acupuncture was shown to be statistically and significantly better than placebo in lengthening the median survival time to rescue drug. We demonstrate here that PH assumptions in the common Cox model did not hold in that trial and that TCM trials warrant more thoughtful modeling and more sophisticated models of statistical analysis. TCM study design entails all the challenges encountered in trials of drugs, devices, and surgical procedures in the Western medicine. We present possible solutions to some but leave many issues unresolved. © 2011 John Wiley & Sons, Ltd.en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0277-6715/en_US
dc.relation.ispartofStatistics in Medicineen_US
dc.subject.meshAcupuncture Therapy - Statistics & Numerical Dataen_US
dc.subject.meshData Interpretation, Statisticalen_US
dc.subject.meshHumansen_US
dc.subject.meshMedicine, Chinese Traditionalen_US
dc.subject.meshRandomized Controlled Trials As Topic - Statistics & Numerical Dataen_US
dc.subject.meshResearch Design - Statistics & Numerical Dataen_US
dc.subject.meshToothache - Therapyen_US
dc.titleEvaluating traditional Chinese medicine using modern clinical trial design and statistical methodology: Application to a randomized controlled acupuncture trialen_US
dc.typeArticleen_US
dc.identifier.emailLao, L: lxlao1@hku.hken_US
dc.identifier.authorityLao, L=rp01784en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/sim.4003en_US
dc.identifier.pmid21344469-
dc.identifier.scopuseid_2-s2.0-84858008939en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84858008939&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume31en_US
dc.identifier.issue7en_US
dc.identifier.spage619en_US
dc.identifier.epage627en_US
dc.identifier.isiWOS:000301121900004-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridLao, L=7005681883en_US
dc.identifier.scopusauthoridHuang, Y=37064693100en_US
dc.identifier.scopusauthoridFeng, C=37030801100en_US
dc.identifier.scopusauthoridBerman, BM=35458606800en_US
dc.identifier.scopusauthoridTan, MT=7401464906en_US

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