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Article: Acupuncture alleviates the affective dimension of pain in a rat model of inflammatory hyperalgesia

TitleAcupuncture alleviates the affective dimension of pain in a rat model of inflammatory hyperalgesia
Authors
Issue Date2011
PublisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0364-3190
Citation
Neurochemical Research, 2011, v. 36 n. 11, p. 2104-2110 How to Cite?
AbstractAlthough studies demonstrate that electroacupuncture (EA) alleviates the sensory dimension of pain, they have not addressed EA's effect on the affective dimension. An inflammatory pain rat model, produced by a complete Freund adjuvant (CFA) injection into the hind paw, was combined with a conditioned place avoidance test to determine EA's effects and its underpinning mechanism on the affective dimension of pain. CFA-injected rats showed place aversion, i.e. the affective dimension of pain, by spending less time in a pain-paired compartment after conditioning than before, while saline-injected rats did not. CFA rats given EA treatment at GB30 before a post-conditioning test showed no aversion to the pain-paired compartment, indicating that EA inhibited the affective response. Intra-rostral anterior cingulate cortex (rACC) administration of a κ-, but not μ-opioid receptor antagonist, blocked EA action. These data demonstrate that EA activates opioid receptors in the rACC to inhibit the affective dimension of pain. © 2011 Springer Science+Business Media, LLC.
Persistent Identifierhttp://hdl.handle.net/10722/188637
ISSN
2015 Impact Factor: 2.472
2015 SCImago Journal Rankings: 1.102
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorZhang, Yen_US
dc.contributor.authorMeng, Xen_US
dc.contributor.authorLi, Aen_US
dc.contributor.authorXin, Jen_US
dc.contributor.authorBerman, BMen_US
dc.contributor.authorLao, Len_US
dc.contributor.authorTan, Men_US
dc.contributor.authorRen, Ken_US
dc.contributor.authorZhang, RXen_US
dc.date.accessioned2013-09-03T04:10:44Z-
dc.date.available2013-09-03T04:10:44Z-
dc.date.issued2011en_US
dc.identifier.citationNeurochemical Research, 2011, v. 36 n. 11, p. 2104-2110en_US
dc.identifier.issn0364-3190en_US
dc.identifier.urihttp://hdl.handle.net/10722/188637-
dc.description.abstractAlthough studies demonstrate that electroacupuncture (EA) alleviates the sensory dimension of pain, they have not addressed EA's effect on the affective dimension. An inflammatory pain rat model, produced by a complete Freund adjuvant (CFA) injection into the hind paw, was combined with a conditioned place avoidance test to determine EA's effects and its underpinning mechanism on the affective dimension of pain. CFA-injected rats showed place aversion, i.e. the affective dimension of pain, by spending less time in a pain-paired compartment after conditioning than before, while saline-injected rats did not. CFA rats given EA treatment at GB30 before a post-conditioning test showed no aversion to the pain-paired compartment, indicating that EA inhibited the affective response. Intra-rostral anterior cingulate cortex (rACC) administration of a κ-, but not μ-opioid receptor antagonist, blocked EA action. These data demonstrate that EA activates opioid receptors in the rACC to inhibit the affective dimension of pain. © 2011 Springer Science+Business Media, LLC.en_US
dc.languageengen_US
dc.publisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0364-3190en_US
dc.relation.ispartofNeurochemical Researchen_US
dc.subject.meshAffect - Physiologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAvoidance Learningen_US
dc.subject.meshConditioning, Classicalen_US
dc.subject.meshDisease Models, Animalen_US
dc.subject.meshElectroacupunctureen_US
dc.subject.meshFreund's Adjuvanten_US
dc.subject.meshGyrus Cinguli - Physiologyen_US
dc.subject.meshHyperalgesia - Therapyen_US
dc.subject.meshInflammation - Therapyen_US
dc.subject.meshMaleen_US
dc.subject.meshNaltrexone - Analogs & Derivatives - Pharmacologyen_US
dc.subject.meshPain Management - Methodsen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Sprague-Dawleyen_US
dc.subject.meshReceptors, Opioid, Kappa - Antagonists & Inhibitorsen_US
dc.subject.meshReceptors, Opioid, Mu - Antagonists & Inhibitorsen_US
dc.subject.meshSomatostatin - Analogs & Derivatives - Pharmacologyen_US
dc.titleAcupuncture alleviates the affective dimension of pain in a rat model of inflammatory hyperalgesiaen_US
dc.typeArticleen_US
dc.identifier.emailLao, L: lxlao1@hku.hken_US
dc.identifier.authorityLao, L=rp01784en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/s11064-011-0534-yen_US
dc.identifier.pmid21695393-
dc.identifier.scopuseid_2-s2.0-80055008372en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-80055008372&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume36en_US
dc.identifier.issue11en_US
dc.identifier.spage2104en_US
dc.identifier.epage2110en_US
dc.identifier.isiWOS:000296523800019-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridZhang, Y=7601332347en_US
dc.identifier.scopusauthoridMeng, X=53064279800en_US
dc.identifier.scopusauthoridLi, A=16245342100en_US
dc.identifier.scopusauthoridXin, J=23104505000en_US
dc.identifier.scopusauthoridBerman, BM=35458606800en_US
dc.identifier.scopusauthoridLao, L=7005681883en_US
dc.identifier.scopusauthoridTan, M=55127194900en_US
dc.identifier.scopusauthoridRen, K=7102272533en_US
dc.identifier.scopusauthoridZhang, RX=7404864527en_US

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