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Article: Electroacupuncture alleviates affective pain in an inflammatory pain rat model

TitleElectroacupuncture alleviates affective pain in an inflammatory pain rat model
Authors
KeywordsAcupuncture
Affective Pain
Anterior Cingulate Cortex
Ctop
Opioid
Issue Date2012
PublisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1002/%28ISSN%291532-2149
Citation
European Journal of Pain, 2012, v. 16 n. 2, p. 170-181 How to Cite?
AbstractPain has both sensory-discriminative and emotional-affective dimensions. Previous studies demonstrate that electroacupuncture (EA) alleviates the sensory dimension but do not address the affective. An inflammatory pain rat model, produced by a complete Freund adjuvant (CFA) injection into the hind paw, was combined with a conditioned place avoidance (CPA) test to determine whether EA inhibits spontaneous pain-induced affective response and, if so, to study the possibility that rostral anterior cingulate cortex (rACC) opioids underlie this effect. Male Sprague-Dawley rats (250-275 g, Harlan) were used. The rats showed place aversion (i.e. affective pain) by spending less time in a pain-paired compartment after conditioning than during a preconditioning test. Systemic non-analgesic morphine (0.5 and 1.0 mg/kg, i.p.) inhibited the affective reaction, suggesting that the affective dimension is underpinned by mechanisms different from those of the sensory dimension of pain. Morphine at 0.5 and at 1 mg/kg did not induce reward. Rats given EA treatment before pain-paired conditioning at GB 30 showed no aversion to the pain-paired compartment, indicating that EA inhibited the affective dimension. EA treatment did not produce reward or aversive effect. Intra-rACC administration of D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr amide (CTOP), a selective mu opioid receptor antagonist, but not norbinaltorphimine (nor-BNI), a selective kappa opioid receptor antagonist, blocked EA inhibition of the affective dimension. These data demonstrate that EA activates opioid receptors in the rACC to inhibit pain-induced affective responses and that EA may be an effective therapy for both the sensory-discriminative and the affective dimensions of pain. © 2011.
Persistent Identifierhttp://hdl.handle.net/10722/188632
ISSN
2015 Impact Factor: 2.9
2015 SCImago Journal Rankings: 1.189
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorZhang, Yen_US
dc.contributor.authorMeng, Xen_US
dc.contributor.authorLi, Aen_US
dc.contributor.authorXin, Jen_US
dc.contributor.authorBerman, BMen_US
dc.contributor.authorLao, Len_US
dc.contributor.authorTan, Men_US
dc.contributor.authorRen, Ken_US
dc.contributor.authorZhang, RXen_US
dc.date.accessioned2013-09-03T04:10:43Z-
dc.date.available2013-09-03T04:10:43Z-
dc.date.issued2012en_US
dc.identifier.citationEuropean Journal of Pain, 2012, v. 16 n. 2, p. 170-181en_US
dc.identifier.issn1090-3801en_US
dc.identifier.urihttp://hdl.handle.net/10722/188632-
dc.description.abstractPain has both sensory-discriminative and emotional-affective dimensions. Previous studies demonstrate that electroacupuncture (EA) alleviates the sensory dimension but do not address the affective. An inflammatory pain rat model, produced by a complete Freund adjuvant (CFA) injection into the hind paw, was combined with a conditioned place avoidance (CPA) test to determine whether EA inhibits spontaneous pain-induced affective response and, if so, to study the possibility that rostral anterior cingulate cortex (rACC) opioids underlie this effect. Male Sprague-Dawley rats (250-275 g, Harlan) were used. The rats showed place aversion (i.e. affective pain) by spending less time in a pain-paired compartment after conditioning than during a preconditioning test. Systemic non-analgesic morphine (0.5 and 1.0 mg/kg, i.p.) inhibited the affective reaction, suggesting that the affective dimension is underpinned by mechanisms different from those of the sensory dimension of pain. Morphine at 0.5 and at 1 mg/kg did not induce reward. Rats given EA treatment before pain-paired conditioning at GB 30 showed no aversion to the pain-paired compartment, indicating that EA inhibited the affective dimension. EA treatment did not produce reward or aversive effect. Intra-rACC administration of D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr amide (CTOP), a selective mu opioid receptor antagonist, but not norbinaltorphimine (nor-BNI), a selective kappa opioid receptor antagonist, blocked EA inhibition of the affective dimension. These data demonstrate that EA activates opioid receptors in the rACC to inhibit pain-induced affective responses and that EA may be an effective therapy for both the sensory-discriminative and the affective dimensions of pain. © 2011.en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1002/%28ISSN%291532-2149en_US
dc.relation.ispartofEuropean Journal of Painen_US
dc.subjectAcupunctureen_US
dc.subjectAffective Painen_US
dc.subjectAnterior Cingulate Cortexen_US
dc.subjectCtopen_US
dc.subjectOpioiden_US
dc.titleElectroacupuncture alleviates affective pain in an inflammatory pain rat modelen_US
dc.typeArticleen_US
dc.identifier.emailLao, L: lxlao1@hku.hken_US
dc.identifier.authorityLao, L=rp01784en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.ejpain.2011.07.002en_US
dc.identifier.pmid22323370-
dc.identifier.scopuseid_2-s2.0-79960891552en_US
dc.identifier.isiWOS:000306900900003-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridZhang, Y=36045630100en_US
dc.identifier.scopusauthoridMeng, X=53064279800en_US
dc.identifier.scopusauthoridLi, A=16245342100en_US
dc.identifier.scopusauthoridXin, J=23104505000en_US
dc.identifier.scopusauthoridBerman, BM=35458606800en_US
dc.identifier.scopusauthoridLao, L=7005681883en_US
dc.identifier.scopusauthoridTan, M=55127194900en_US
dc.identifier.scopusauthoridRen, K=7102272533en_US
dc.identifier.scopusauthoridZhang, RX=7404864527en_US

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