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Article: Suppression of ongoing experimental arthritis by a Chinese herbal formula (Huo-Luo-Xiao-Ling Dan) involves changes in antigen-induced immunological and biochemical mediators of inflammation

TitleSuppression of ongoing experimental arthritis by a Chinese herbal formula (Huo-Luo-Xiao-Ling Dan) involves changes in antigen-induced immunological and biochemical mediators of inflammation
Authors
Issue Date2011
PublisherHindawi Publishing Corporation. The Journal's web site is located at http://www.hindawi.com/journals/ecam/
Citation
Evidence-Based Complementary And Alternative Medicine, 2011, v. 2011 How to Cite?
AbstractRheumatoid arthritis (RA) is one of the major autoimmune diseases of global prevalence. The use of the anti-inflammatory drugs for the treatment of RA is associated with severe adverse reactions and toxicity. This limitation has necessitated the search for novel therapeutic products. We report here a traditional Chinese medicine-based herbal formula, Huo luo xiao ling dan (HLXL), which has potent antiarthritic activity as validated in the rat adjuvant-induced arthritis (AA) model. HLXL (2.3g/Kg) was fed to Lewis (RT. 1 1) rats daily by gavage beginning at the onset of arthritis and then continued through the observation period. HLXL inhibited the severity of ongoing AA. This suppression of arthritis was associated with significant alterations in the T cell proliferative and cytokine responses as well as the antibody response against the disease-related antigen, mycobacterial heat-shock protein 65 (Bhsp65). There was a reduction in the level of the proinflammatory cytokines IL-17 and IL-1 but enhancement of the anti-inflammatory cytokine IL-10 level. In addition, there was inhibition of both the anti-Bhsp65 antibody response and the serum level of nitric oxide. Thus, HLXL is a promising CAM modality for further testing in RA patients. Copyright © 2011 Ying-Hua Yang et al.
Persistent Identifierhttp://hdl.handle.net/10722/188625
ISSN
2015 Impact Factor: 1.931
2015 SCImago Journal Rankings: 0.615
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorMoudgil, KDen_US
dc.contributor.authorYang, YHen_US
dc.contributor.authorRajaiah, Ren_US
dc.contributor.authorLee, DYWen_US
dc.contributor.authorMa, Zen_US
dc.contributor.authorYu, Hen_US
dc.contributor.authorFong, HHSen_US
dc.contributor.authorLao, Len_US
dc.contributor.authorBerman, BMen_US
dc.date.accessioned2013-09-03T04:10:41Z-
dc.date.available2013-09-03T04:10:41Z-
dc.date.issued2011en_US
dc.identifier.citationEvidence-Based Complementary And Alternative Medicine, 2011, v. 2011en_US
dc.identifier.issn1741-427Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/188625-
dc.description.abstractRheumatoid arthritis (RA) is one of the major autoimmune diseases of global prevalence. The use of the anti-inflammatory drugs for the treatment of RA is associated with severe adverse reactions and toxicity. This limitation has necessitated the search for novel therapeutic products. We report here a traditional Chinese medicine-based herbal formula, Huo luo xiao ling dan (HLXL), which has potent antiarthritic activity as validated in the rat adjuvant-induced arthritis (AA) model. HLXL (2.3g/Kg) was fed to Lewis (RT. 1 1) rats daily by gavage beginning at the onset of arthritis and then continued through the observation period. HLXL inhibited the severity of ongoing AA. This suppression of arthritis was associated with significant alterations in the T cell proliferative and cytokine responses as well as the antibody response against the disease-related antigen, mycobacterial heat-shock protein 65 (Bhsp65). There was a reduction in the level of the proinflammatory cytokines IL-17 and IL-1 but enhancement of the anti-inflammatory cytokine IL-10 level. In addition, there was inhibition of both the anti-Bhsp65 antibody response and the serum level of nitric oxide. Thus, HLXL is a promising CAM modality for further testing in RA patients. Copyright © 2011 Ying-Hua Yang et al.en_US
dc.languageengen_US
dc.publisherHindawi Publishing Corporation. The Journal's web site is located at http://www.hindawi.com/journals/ecam/en_US
dc.relation.ispartofEvidence-based Complementary and Alternative Medicineen_US
dc.titleSuppression of ongoing experimental arthritis by a Chinese herbal formula (Huo-Luo-Xiao-Ling Dan) involves changes in antigen-induced immunological and biochemical mediators of inflammationen_US
dc.typeArticleen_US
dc.identifier.emailLao, L: lxlao1@hku.hken_US
dc.identifier.authorityLao, L=rp01784en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1155/2011/642027en_US
dc.identifier.scopuseid_2-s2.0-78349285203en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-78349285203&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume2011en_US
dc.identifier.isiWOS:000293522000001-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridMoudgil, KD=7003544028en_US
dc.identifier.scopusauthoridYang, YH=36626723700en_US
dc.identifier.scopusauthoridRajaiah, R=24329548500en_US
dc.identifier.scopusauthoridLee, DYW=24465228000en_US
dc.identifier.scopusauthoridMa, Z=8709903000en_US
dc.identifier.scopusauthoridYu, H=36550862200en_US
dc.identifier.scopusauthoridFong, HHS=34569199300en_US
dc.identifier.scopusauthoridLao, L=7005681883en_US
dc.identifier.scopusauthoridBerman, BM=35458606800en_US

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