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Article: Cinnamomum cassia bark in two herbal formulas increases life span in Caenorhabditis elegansvia insulin signaling and stress response pathways

TitleCinnamomum cassia bark in two herbal formulas increases life span in Caenorhabditis elegansvia insulin signaling and stress response pathways
Authors
Issue Date2010
PublisherPublic Library of Science. The Journal's web site is located at http://www.plosone.org/home.action
Citation
Plos One, 2010, v. 5 n. 2 How to Cite?
AbstractBackground: Proving the efficacy and corresponding mode of action of herbal supplements is a difficult challenge for evidence-based herbal therapy. A major hurdle is the complexity of herbal preparations, many of which combine multiple herbs, particularly when the combination is assumed to be vitally important to the effectiveness of the herbal therapy. This issue may be addressed through the use of contemporary methodology and validated animal models. Methods and Principal Findings: In this study, two commonly used traditional herbal formulas, Shi Quan Da Bu Tang (SQDB) and Huo Luo Xiao Ling Dan (HLXL) were evaluated using a survival assay and oxidative stress biomarkers in a well-established C. elegans model of aging. HLXL is an eleven herb formula modified from a top-selling traditional herbal formula for the treatment of arthritic joint pain. SQDB consists of ten herbs often used for fatigue and energy, particularly in the aged. We demonstrate here that SQDB significantly extend life span in a C. elegans model of aging. Among all individual herbs tested, two herbs Cinnamomum cassia bark (Chinese pharmaceutical name: Cinnamomi Cortex, CIN) and Panax ginseng root (Chinese pharmaceutical name: Ginseng Radix, GS) significantly extended life span in C. elegans. CIN in both SQDB and HLXL formula extended life span via modulation of multiple longevity assurance genes, including genes involved in insulin signaling and stress response pathways. All the life-span-extending herbs (SQDB, CIN and GS) also attenuated levels of H2O2 and enhanced small heat shock protein expression. Furthermore, the life spanextending herbs significantly delayed human amyloid beta (Aβ)-induced toxicity in transgenic C. elegans expressing human Aβ. Conclusion/Significance:These results validate an invertebrate model for rapid, systematic evaluation of commonly used Chinese herbal formulations and may provide insight for designing future evidence-based herbal therapy(s). Copyright: © 2010 Yu et al.
Persistent Identifierhttp://hdl.handle.net/10722/188617
ISSN
2015 Impact Factor: 3.057
2015 SCImago Journal Rankings: 1.395
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorYu, YBen_US
dc.contributor.authorDosanjh, Len_US
dc.contributor.authorLao, Len_US
dc.contributor.authorTan, Men_US
dc.contributor.authorShim, BSen_US
dc.contributor.authorLuo, Yen_US
dc.date.accessioned2013-09-03T04:10:38Z-
dc.date.available2013-09-03T04:10:38Z-
dc.date.issued2010en_US
dc.identifier.citationPlos One, 2010, v. 5 n. 2en_US
dc.identifier.issn1932-6203en_US
dc.identifier.urihttp://hdl.handle.net/10722/188617-
dc.description.abstractBackground: Proving the efficacy and corresponding mode of action of herbal supplements is a difficult challenge for evidence-based herbal therapy. A major hurdle is the complexity of herbal preparations, many of which combine multiple herbs, particularly when the combination is assumed to be vitally important to the effectiveness of the herbal therapy. This issue may be addressed through the use of contemporary methodology and validated animal models. Methods and Principal Findings: In this study, two commonly used traditional herbal formulas, Shi Quan Da Bu Tang (SQDB) and Huo Luo Xiao Ling Dan (HLXL) were evaluated using a survival assay and oxidative stress biomarkers in a well-established C. elegans model of aging. HLXL is an eleven herb formula modified from a top-selling traditional herbal formula for the treatment of arthritic joint pain. SQDB consists of ten herbs often used for fatigue and energy, particularly in the aged. We demonstrate here that SQDB significantly extend life span in a C. elegans model of aging. Among all individual herbs tested, two herbs Cinnamomum cassia bark (Chinese pharmaceutical name: Cinnamomi Cortex, CIN) and Panax ginseng root (Chinese pharmaceutical name: Ginseng Radix, GS) significantly extended life span in C. elegans. CIN in both SQDB and HLXL formula extended life span via modulation of multiple longevity assurance genes, including genes involved in insulin signaling and stress response pathways. All the life-span-extending herbs (SQDB, CIN and GS) also attenuated levels of H2O2 and enhanced small heat shock protein expression. Furthermore, the life spanextending herbs significantly delayed human amyloid beta (Aβ)-induced toxicity in transgenic C. elegans expressing human Aβ. Conclusion/Significance:These results validate an invertebrate model for rapid, systematic evaluation of commonly used Chinese herbal formulations and may provide insight for designing future evidence-based herbal therapy(s). Copyright: © 2010 Yu et al.en_US
dc.languageengen_US
dc.publisherPublic Library of Science. The Journal's web site is located at http://www.plosone.org/home.actionen_US
dc.relation.ispartofPLoS ONEen_US
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshAging - Drug Effectsen_US
dc.subject.meshAmyloid Beta-Peptides - Genetics - Metabolismen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAnimals, Genetically Modifieden_US
dc.subject.meshCaenorhabditis Elegans - Genetics - Metabolism - Physiologyen_US
dc.subject.meshCaenorhabditis Elegans Proteins - Genetics - Metabolismen_US
dc.subject.meshCinnamomum Aromaticum - Chemistryen_US
dc.subject.meshDrugs, Chinese Herbal - Pharmacologyen_US
dc.subject.meshGreen Fluorescent Proteins - Genetics - Metabolismen_US
dc.subject.meshHeat-Shock Proteins - Genetics - Metabolismen_US
dc.subject.meshHeat-Shock Proteins, Small - Metabolismen_US
dc.subject.meshHumansen_US
dc.subject.meshHydrogen Peroxide - Metabolismen_US
dc.subject.meshLongevity - Drug Effectsen_US
dc.subject.meshMicroscopy, Fluorescenceen_US
dc.subject.meshModels, Animalen_US
dc.subject.meshOxidative Stress - Drug Effects - Physiologyen_US
dc.subject.meshParalysis - Genetics - Metabolism - Prevention & Controlen_US
dc.subject.meshPlant Bark - Chemistryen_US
dc.subject.meshReceptor, Insulin - Physiologyen_US
dc.subject.meshSignal Transduction - Drug Effectsen_US
dc.subject.meshTime Factorsen_US
dc.titleCinnamomum cassia bark in two herbal formulas increases life span in Caenorhabditis elegansvia insulin signaling and stress response pathwaysen_US
dc.typeArticleen_US
dc.identifier.emailLao, L: lxlao1@hku.hken_US
dc.identifier.authorityLao, L=rp01784en_US
dc.description.naturepublished_or_final_versionen_US
dc.identifier.doi10.1371/journal.pone.0009339en_US
dc.identifier.pmid20179756-
dc.identifier.scopuseid_2-s2.0-77949651722en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77949651722&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume5en_US
dc.identifier.issue2en_US
dc.identifier.isiWOS:000274923900008-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridYu, YB=9744770500en_US
dc.identifier.scopusauthoridDosanjh, L=35519418500en_US
dc.identifier.scopusauthoridLao, L=7005681883en_US
dc.identifier.scopusauthoridTan, M=55127194900en_US
dc.identifier.scopusauthoridShim, BS=23092300700en_US
dc.identifier.scopusauthoridLuo, Y=55712616300en_US

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