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Article: Electroacupuncture suppresses hyperalgesia and spinal Fos expression by activating the descending inhibitory system

TitleElectroacupuncture suppresses hyperalgesia and spinal Fos expression by activating the descending inhibitory system
Authors
Issue Date2007
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/brainres
Citation
Brain Research, 2007, v. 1186 n. 1, p. 171-179 How to Cite?
AbstractAlthough electroacupuncture (EA) is widely used to treat pain, its mechanisms have not been completely understood. The present study investigated the descending inhibitory system involvement in EA action. Inflammatory pain was induced by injecting complete Freund's adjuvant subcutaneously into one hind paw of rats with dorsolateral funiculus lesions and sham-operated rats. EA treatment, 10 Hz at 3 mA, was given twice for 20 min each, once immediately post- and again 2 h post-Freund's adjuvant at GB 30, at the junction of the lateral 1/3 and medial 2/3 of the distance between the greater trochanter and sacral hiatus. For sham EA control, acupuncture needles were inserted bilaterally into GB 30 without electrical or manual stimulation. Paw withdrawal latency to a noxious thermal stimulus was measured at baseline and 20 min after EA treatment. Compared to sham EA, EA significantly (P < 0.05, n = 9) increased withdrawal latency of the inflamed hind paws in the sham-operated rats but not in those with dorsolateral funiculus lesions, indicating that lesioning blocked EA-produced anti-hyperalgesia. EA, compared to sham EA, also significantly inhibited Fos expression in laminae I-II of the spinal cord in the sham-operated rats (58.4 ± 6.5 vs. 35.2 ± 5.4 per section) but not in those with dorsolateral funiculus lesions. Further, EA activated serotonin- and catecholamine-containing neurons in the nucleus raphe magnus and locus coeruleus that project to the spinal cord. The results demonstrate that EA inhibits transmission of noxious messages and hyperalgesia by activating supraspinal neurons that project to the spinal cord. © 2007 Elsevier B.V. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/188590
ISSN
2015 Impact Factor: 2.561
2015 SCImago Journal Rankings: 1.351
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLi, Aen_US
dc.contributor.authorWang, Yen_US
dc.contributor.authorXin, Jen_US
dc.contributor.authorLao, Len_US
dc.contributor.authorRen, Ken_US
dc.contributor.authorBerman, BMen_US
dc.contributor.authorZhang, RXen_US
dc.date.accessioned2013-09-03T04:10:28Z-
dc.date.available2013-09-03T04:10:28Z-
dc.date.issued2007en_US
dc.identifier.citationBrain Research, 2007, v. 1186 n. 1, p. 171-179en_US
dc.identifier.issn0006-8993en_US
dc.identifier.urihttp://hdl.handle.net/10722/188590-
dc.description.abstractAlthough electroacupuncture (EA) is widely used to treat pain, its mechanisms have not been completely understood. The present study investigated the descending inhibitory system involvement in EA action. Inflammatory pain was induced by injecting complete Freund's adjuvant subcutaneously into one hind paw of rats with dorsolateral funiculus lesions and sham-operated rats. EA treatment, 10 Hz at 3 mA, was given twice for 20 min each, once immediately post- and again 2 h post-Freund's adjuvant at GB 30, at the junction of the lateral 1/3 and medial 2/3 of the distance between the greater trochanter and sacral hiatus. For sham EA control, acupuncture needles were inserted bilaterally into GB 30 without electrical or manual stimulation. Paw withdrawal latency to a noxious thermal stimulus was measured at baseline and 20 min after EA treatment. Compared to sham EA, EA significantly (P < 0.05, n = 9) increased withdrawal latency of the inflamed hind paws in the sham-operated rats but not in those with dorsolateral funiculus lesions, indicating that lesioning blocked EA-produced anti-hyperalgesia. EA, compared to sham EA, also significantly inhibited Fos expression in laminae I-II of the spinal cord in the sham-operated rats (58.4 ± 6.5 vs. 35.2 ± 5.4 per section) but not in those with dorsolateral funiculus lesions. Further, EA activated serotonin- and catecholamine-containing neurons in the nucleus raphe magnus and locus coeruleus that project to the spinal cord. The results demonstrate that EA inhibits transmission of noxious messages and hyperalgesia by activating supraspinal neurons that project to the spinal cord. © 2007 Elsevier B.V. All rights reserved.en_US
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/brainresen_US
dc.relation.ispartofBrain Researchen_US
dc.subject.meshAnimalsen_US
dc.subject.meshElectroacupunctureen_US
dc.subject.meshHyperalgesia - Metabolism - Physiopathology - Therapyen_US
dc.subject.meshMaleen_US
dc.subject.meshPain Threshold - Physiologyen_US
dc.subject.meshPosterior Horn Cells - Metabolism - Physiopathologyen_US
dc.subject.meshProto-Oncogene Proteins C-Fos - Metabolismen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Sprague-Dawleyen_US
dc.subject.meshSpinal Cord - Metabolism - Physiopathologyen_US
dc.titleElectroacupuncture suppresses hyperalgesia and spinal Fos expression by activating the descending inhibitory systemen_US
dc.typeArticleen_US
dc.identifier.emailLao, L: lxlao1@hku.hken_US
dc.identifier.authorityLao, L=rp01784en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.brainres.2007.10.022en_US
dc.identifier.pmid18001697-
dc.identifier.scopuseid_2-s2.0-37649000029en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-37649000029&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume1186en_US
dc.identifier.issue1en_US
dc.identifier.spage171en_US
dc.identifier.epage179en_US
dc.identifier.isiWOS:000252201500019-
dc.publisher.placeNetherlandsen_US
dc.identifier.scopusauthoridLi, A=16245342100en_US
dc.identifier.scopusauthoridWang, Y=7601488320en_US
dc.identifier.scopusauthoridXin, J=23104505000en_US
dc.identifier.scopusauthoridLao, L=7005681883en_US
dc.identifier.scopusauthoridRen, K=7102272533en_US
dc.identifier.scopusauthoridBerman, BM=35458606800en_US
dc.identifier.scopusauthoridZhang, RX=7404864527en_US

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