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Article: Effects of an acetone extract of Boswellia carterii Birdw. (Burseraceae) gum resin on adjuvant-induced arthritis in lewis rats

TitleEffects of an acetone extract of Boswellia carterii Birdw. (Burseraceae) gum resin on adjuvant-induced arthritis in lewis rats
Authors
Issue Date2005
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/jethpharm
Citation
Journal Of Ethnopharmacology, 2005, v. 101 n. 1-3, p. 104-109 How to Cite?
AbstractRuxiang (Gummi olibanum), the dried gum resin of Boswellia carterii (BC), has been used in traditional Chinese medicine to alleviate pain and inflammation for thousands of years. In this random, blinded study, the anti-arthritic effects of a BC extract were observed and compared to vehicle control in a Lewis rat adjuvant arthritis model (n = 8/group). Arthritis was induced by injecting CFA subcutaneously into the base of the tail, and the extract was administered orally (i.g.) for 10 consecutive days beginning on day 16 after the injection. Arthritic scores, paw edema, and the local tissue pro-inflammatory cytokines tumor necrosis factor alpha (TNF-α) and interleukin-1 beta (IL-1β) were assessed. Toxicity and adverse effects of the extract were evaluated. At 0.90 g/kg per day, BC significantly decreased arthritic scores between days 20 and 25 (p < 0.05) and reduced paw edema on days 18, 20 and 22 compared to control (p < 0.05). It also significantly suppressed local tissue TNF-α and IL-1β (p < 0.05). No major adverse effects were observed in animals during the repeated-dose treatment profile although mild fur discoloration was noted. The data show that BC extract has significant anti-arthritic and anti-inflammation effects and suggest that these effects may be mediated via the suppression of pro-inflammatory cytokines. © 2005 Elsevier Ireland Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/188575
ISSN
2015 Impact Factor: 3.055
2015 SCImago Journal Rankings: 1.156
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorFan, AYen_US
dc.contributor.authorLao, Len_US
dc.contributor.authorZhang, RXen_US
dc.contributor.authorZhou, ANen_US
dc.contributor.authorWang, LBen_US
dc.contributor.authorMoudgil, KDen_US
dc.contributor.authorLee, DYWen_US
dc.contributor.authorMa, ZZen_US
dc.contributor.authorZhang, WYen_US
dc.contributor.authorBerman, BMen_US
dc.date.accessioned2013-09-03T04:10:24Z-
dc.date.available2013-09-03T04:10:24Z-
dc.date.issued2005en_US
dc.identifier.citationJournal Of Ethnopharmacology, 2005, v. 101 n. 1-3, p. 104-109en_US
dc.identifier.issn0378-8741en_US
dc.identifier.urihttp://hdl.handle.net/10722/188575-
dc.description.abstractRuxiang (Gummi olibanum), the dried gum resin of Boswellia carterii (BC), has been used in traditional Chinese medicine to alleviate pain and inflammation for thousands of years. In this random, blinded study, the anti-arthritic effects of a BC extract were observed and compared to vehicle control in a Lewis rat adjuvant arthritis model (n = 8/group). Arthritis was induced by injecting CFA subcutaneously into the base of the tail, and the extract was administered orally (i.g.) for 10 consecutive days beginning on day 16 after the injection. Arthritic scores, paw edema, and the local tissue pro-inflammatory cytokines tumor necrosis factor alpha (TNF-α) and interleukin-1 beta (IL-1β) were assessed. Toxicity and adverse effects of the extract were evaluated. At 0.90 g/kg per day, BC significantly decreased arthritic scores between days 20 and 25 (p < 0.05) and reduced paw edema on days 18, 20 and 22 compared to control (p < 0.05). It also significantly suppressed local tissue TNF-α and IL-1β (p < 0.05). No major adverse effects were observed in animals during the repeated-dose treatment profile although mild fur discoloration was noted. The data show that BC extract has significant anti-arthritic and anti-inflammation effects and suggest that these effects may be mediated via the suppression of pro-inflammatory cytokines. © 2005 Elsevier Ireland Ltd. All rights reserved.en_US
dc.languageengen_US
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/jethpharmen_US
dc.relation.ispartofJournal of Ethnopharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshArthritis, Experimental - Drug Therapyen_US
dc.subject.meshBoswellia - Chemistryen_US
dc.subject.meshDrugs, Chinese Herbal - Pharmacology - Therapeutic Useen_US
dc.subject.meshInterleukin-1 - Analysisen_US
dc.subject.meshMaleen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Inbred Lewen_US
dc.subject.meshResins, Plant - Therapeutic Useen_US
dc.subject.meshTumor Necrosis Factor-Alpha - Analysisen_US
dc.titleEffects of an acetone extract of Boswellia carterii Birdw. (Burseraceae) gum resin on adjuvant-induced arthritis in lewis ratsen_US
dc.typeArticleen_US
dc.identifier.emailLao, L: lxlao1@hku.hken_US
dc.identifier.authorityLao, L=rp01784en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.jep.2005.03.033en_US
dc.identifier.pmid15970410-
dc.identifier.scopuseid_2-s2.0-24644469680en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-24644469680&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume101en_US
dc.identifier.issue1-3en_US
dc.identifier.spage104en_US
dc.identifier.epage109en_US
dc.identifier.isiWOS:000232312200016-
dc.publisher.placeIrelanden_US
dc.identifier.scopusauthoridFan, AY=7005672886en_US
dc.identifier.scopusauthoridLao, L=7005681883en_US
dc.identifier.scopusauthoridZhang, RX=7404864527en_US
dc.identifier.scopusauthoridZhou, AN=55161019400en_US
dc.identifier.scopusauthoridWang, LB=9036448600en_US
dc.identifier.scopusauthoridMoudgil, KD=7003544028en_US
dc.identifier.scopusauthoridLee, DYW=55808069935en_US
dc.identifier.scopusauthoridMa, ZZ=8709903000en_US
dc.identifier.scopusauthoridZhang, WY=7409432776en_US
dc.identifier.scopusauthoridBerman, BM=35458606800en_US

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