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- Publisher Website: 10.1016/j.brainres.2005.05.008
- Scopus: eid_2-s2.0-20444406071
- PMID: 15922310
- WOS: WOS:000230259600028
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Article: Mu opioid receptor-containing neurons mediate electroacupuncture-produced anti-hyperalgesia in rats with hind paw inflammation
Title | Mu opioid receptor-containing neurons mediate electroacupuncture-produced anti-hyperalgesia in rats with hind paw inflammation |
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Authors | |
Keywords | Acupuncture Dermorphin-saporin Hyperalgesia Pain Rat Spinal cord |
Issue Date | 2005 |
Publisher | Elsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/brainres |
Citation | Brain Research, 2005, v. 1048 n. 1-2, p. 235-240 How to Cite? |
Abstract | Previous studies showed that electroacupuncture (EA) significantly attenuates inflammatory hyperalgesia in a complete Freund's adjuvant (CFA)-induced inflammatory pain rat model. The present study demonstrates that pretreatment with Derm-sap, a selective toxin for neurons that contain mu opioid receptor (MOR), specifically decreases MOR and blocks EA anti-hyperalgesia. These data suggest that spinal MOR-containing neurons are involved in the processes by which EA produces anti-hyperalgesia. © 2005 Elsevier B.V. All rights reserved. |
Persistent Identifier | http://hdl.handle.net/10722/188571 |
ISSN | 2023 Impact Factor: 2.7 2023 SCImago Journal Rankings: 0.832 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Zhang, RX | en_US |
dc.contributor.author | Wang, L | en_US |
dc.contributor.author | Liu, B | en_US |
dc.contributor.author | Qiao, JT | en_US |
dc.contributor.author | Ren, K | en_US |
dc.contributor.author | Berman, BM | en_US |
dc.contributor.author | Lao, L | en_US |
dc.date.accessioned | 2013-09-03T04:10:20Z | - |
dc.date.available | 2013-09-03T04:10:20Z | - |
dc.date.issued | 2005 | en_US |
dc.identifier.citation | Brain Research, 2005, v. 1048 n. 1-2, p. 235-240 | en_US |
dc.identifier.issn | 0006-8993 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/188571 | - |
dc.description.abstract | Previous studies showed that electroacupuncture (EA) significantly attenuates inflammatory hyperalgesia in a complete Freund's adjuvant (CFA)-induced inflammatory pain rat model. The present study demonstrates that pretreatment with Derm-sap, a selective toxin for neurons that contain mu opioid receptor (MOR), specifically decreases MOR and blocks EA anti-hyperalgesia. These data suggest that spinal MOR-containing neurons are involved in the processes by which EA produces anti-hyperalgesia. © 2005 Elsevier B.V. All rights reserved. | en_US |
dc.language | eng | en_US |
dc.publisher | Elsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/brainres | en_US |
dc.relation.ispartof | Brain Research | en_US |
dc.subject | Acupuncture | - |
dc.subject | Dermorphin-saporin | - |
dc.subject | Hyperalgesia | - |
dc.subject | Pain | - |
dc.subject | Rat | - |
dc.subject | Spinal cord | - |
dc.subject.mesh | Analysis Of Variance | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Blotting, Western - Methods | en_US |
dc.subject.mesh | Electroacupuncture - Methods | en_US |
dc.subject.mesh | Freund's Adjuvant - Adverse Effects | en_US |
dc.subject.mesh | Hindlimb - Drug Effects - Innervation | en_US |
dc.subject.mesh | Hyperalgesia - Etiology - Therapy | en_US |
dc.subject.mesh | Immunohistochemistry - Methods | en_US |
dc.subject.mesh | Inflammation - Chemically Induced - Complications | en_US |
dc.subject.mesh | Lectins - Metabolism | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | N-Glycosyl Hydrolases | en_US |
dc.subject.mesh | Neurons - Metabolism | en_US |
dc.subject.mesh | Opioid Peptides | en_US |
dc.subject.mesh | Pain Measurement - Methods | en_US |
dc.subject.mesh | Random Allocation | en_US |
dc.subject.mesh | Rats | en_US |
dc.subject.mesh | Rats, Sprague-Dawley | en_US |
dc.subject.mesh | Reaction Time - Drug Effects | en_US |
dc.subject.mesh | Receptors, Opioid, Delta - Metabolism | en_US |
dc.subject.mesh | Receptors, Opioid, Mu - Metabolism | en_US |
dc.subject.mesh | Recombinant Fusion Proteins - Pharmacology | en_US |
dc.subject.mesh | Ribosome Inactivating Proteins, Type 1 | en_US |
dc.subject.mesh | Skin - Drug Effects - Innervation | en_US |
dc.subject.mesh | Spinal Cord - Cytology - Drug Effects - Metabolism | en_US |
dc.subject.mesh | Substance P - Metabolism | en_US |
dc.title | Mu opioid receptor-containing neurons mediate electroacupuncture-produced anti-hyperalgesia in rats with hind paw inflammation | en_US |
dc.type | Article | en_US |
dc.identifier.email | Lao, L: lxlao1@hku.hk | en_US |
dc.identifier.authority | Lao, L=rp01784 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1016/j.brainres.2005.05.008 | en_US |
dc.identifier.pmid | 15922310 | en_US |
dc.identifier.scopus | eid_2-s2.0-20444406071 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-20444406071&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 1048 | en_US |
dc.identifier.issue | 1-2 | en_US |
dc.identifier.spage | 235 | en_US |
dc.identifier.epage | 240 | en_US |
dc.identifier.isi | WOS:000230259600028 | - |
dc.publisher.place | Netherlands | en_US |
dc.identifier.scopusauthorid | Zhang, RX=7404864527 | en_US |
dc.identifier.scopusauthorid | Wang, L=9036448600 | en_US |
dc.identifier.scopusauthorid | Liu, B=55720712900 | en_US |
dc.identifier.scopusauthorid | Qiao, JT=7103301572 | en_US |
dc.identifier.scopusauthorid | Ren, K=7102272533 | en_US |
dc.identifier.scopusauthorid | Berman, BM=35458606800 | en_US |
dc.identifier.scopusauthorid | Lao, L=7005681883 | en_US |
dc.identifier.issnl | 0006-8993 | - |